novartis master thesis

We are looking for a highly motivated master student/intern to investigate the role of epigenetic factors as novel therapeutic targets in haematological malignancies.

Through the scientific intern program at the Novartis Institutes for BioMedical Research (NIBR) you will gain valuable industry experience while being exposed to the exciting field of drug discovery. The project aims to understand the significance of certain epigenetic factors in the pathogenesis of lymphomas as well as determine their potential as drug targets. The applicant will establish and use a broad range of molecular, biochemical and cellular methods and technologies such as RNAi screening, virus production and transduction, cell culture, PCR and western blotting. The project includes an international collaboration with Cambridge, MA.The NIBR Traineeship Program is a paid internship http://www.nibr.com/careers/internships.shtml

Through the scientific intern program at the Novartis Institutes for BioMedical Research (NIBR) you will gain valuable industry experience while being exposed to the exciting field of drug discovery. The project aims to understand the significance of certain epigenetic factors in the pathogenesis of lymphomas as well as determine their potential as drug targets. The applicant will establish and use a broad range of molecular, biochemical and cellular methods and technologies such as RNAi screening, virus production and transduction, cell culture, PCR and western blotting. The project includes an international collaboration with Cambridge, MA.The NIBR Traineeship Program is a paid internship http://www.nibr.com/careers/internships.shtml

**Requirements** Fluency in English, strong interest in oncology and epigenetics, cell culture experience necessary, experience with lentivirus is an advantage. **Location** Novartis Institutes for BioMedical Research (NIBR), Basel http://nibr.com/about/locations.shtml

**Requirements**
Fluency in English, strong interest in oncology and epigenetics, cell culture experience necessary, experience with lentivirus is an advantage.

**Location**
Novartis Institutes for BioMedical Research (NIBR), Basel http://nibr.com/about/locations.shtml

Vanessa Craig, PhD Novartis Pharma AG Klybeckstrasse 141 CH-4057 Basel Switzerland mailto:[email protected]

Vanessa Craig, PhD Novartis Pharma AG Klybeckstrasse 141 CH-4057 Basel Switzerland mailto:[email protected]

Novartis (CORP CH)

• Organizational Units Faculty of Theology Faculty of Law Faculty of Medicine Department of Biomedical Engineering Department of Biomedicine Department of Clinical Research Department of Public Health Department of Sport, Exercise and Health Institute of Molecular and Clinical Ophthalmology Basel Faculty of Humanities and Social Sciences Department of Ancient Civilizations Department of History Department of Social Sciences Department of Arts, Media, Philosophy Department of Languages and Literatures Non Departmental Units Faculty of Science Department Biozentrum Department of Chemistry Department of Physics Department of Mathematics and Computer Science Department of Pharmaceutical Sciences Department of Environmental Sciences Faculty of Business and Economics Faculty of Psychology Institutes Institute for Biomedical Ethics (IBMB) Institute for European Global Studies Center for Philanthropy Studies (CEPS) Institute for Educational Sciences Associated Institutions Swiss Tropical and Public Health Institute (Swiss TPH) Friedrich Miescher Institute for Biomedical Research (FMI) Swiss Peace Foundation Basel Institute on Governance Institute of Molecular and Clinical Ophthalmology Basel (IOB) Research Infrastructures & Collections (links will work later) University Library 3D Print Lab BioEM Lab Bioinformatics Core Facility Center for Data Analytics (CeDA) Center for medical Image Analysis & Navigation (CIAN) Center for Transgenic Models (CTM) Cleanroom Facility Basel Good Manufacturing Practice (GMP) Facility ETH-UniBasel-USB Histology Core Facility Imaging Core Facility Kernspinresonanz – Swiss High-field NMR Facility Microscopy Core Facility Microscopy Network Basel (MNB) Mikro- und Nanotomographie Proteomics Core Facility Research and Infrastructure Support (RISE) sciCORE
• Projects & Collaborations

PhD Thesis: Technologies for Vascularized Skin Equivalents to Study Cutaneous Wound Healing in Vitro

Ruffner, Heinz and Aebi, Alexandra (2020) PhD Thesis: Technologies for Vascularized Skin Equivalents to Study Cutaneous Wound Healing in Vitro. PhD Thesis. ISSN NA

PhD Thesis, Lisa Kiesewetter, "Technische Fakultät der Friedrich-Alexander-Universität Erlangen-Nürnberg zur Erlangung des Doktorgrades Dr.-Ing." University of Erlangen-Nürnberg, Germany.

Some of the work mentioned in the thesis are based on a Master Service Agreement of NIBR with the Fraunhofer Institute, dated August 14, 2015, aimed at a publication for the establishment of an in vitro skin model (exchange of protocols, reagents, positive control recombinant growth factor IGF-1). Due to lack of efficacy of the tested agents in the models, the data have not been submitted for publication. The NIBR contributions are mentioned on the following sections of the thesis: Methods: pp. 66-67 Results: pp. 88-94 Discussion: pp. 151-152 Appendix: p. 203 Acknowledgements: p. 211

The two NVS employees mentioned below are acknowledged in the thesis, but they are not authors.

The models presented in this thesis should provide new, sophisticated alternatives for animal experiments in the field of research on cutaneous wound healing. Novel active pharmaceutical ingredients can be studied employing wound models meeting the specific experimental needs and biological complexity, while not solely restricted to biochemical and histological readout parameters.

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Master theses

Malin Astrid Hermeling  (HHU 2021) Evaluation of nanoparticle-based process concept for the production of amorphous solid dispersions Mitbetreuung: Roman Heumann, Bayer AG  

Ikram Arahouan  (HHU 2021) Investigations on characterization, therapeutic protein interaction and stress resistance of SiO 2 coated packaging surfaces in the context of a universal surface container concept Mitbetreuung: Dr. Karoline Bechtold-Peters, Novartis AG  

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• Bakul Sarker  (HHU 2021) Evaluation of an electronic liquid dosing system for individualised capsule dosing  
• Manh Thong Le  (HHU 2020) Prediction of tablet properties via ZoomLab TM expert system  
• Hendrik Hübscher  (HHU 2020) Impact of binder properties on granule and tablet characteristics produced by twin-screw granulation Mitbetreuung: Dr. Christian Mühlenfeld, Ashland

Associate Analyst - Master Data Management

About the role.

Location: Hyderabad

About the Role:

Responsible for the site Master Data processes aimed to ensure accurate and timely creation and maintenance of the master data in the ERP System, in accordance with local and global requirements. -The Material Planner drives the tactical purchasing process for all materials to ensure materials availability and execution plan feasibility in accordance with Site inventory policy.     

Key Responsibilities:  

• Master Data -Set up and perform complex local And global master data set up And establish process, guidelines, business matrix and SLA time lines in in GxP environment in adherence to Novartis compliance.
• Be SME in the assigned area of work -Support data collection and reporting of important metrics -Logistic, WAndD -Responsible that all logistic processes are proceed in a timely, high quality, efficient and effective manner and in full compliance with all laws and supply chain management policies and procedures.
• Identify and drive continuous improvement projects.
• Ensure material availability in line with the approved production plan.
• Ensure daily MRP oversight for all BOM material, analysis of requirements and Purchase Orders management.
• Own, in ERP System, MRP relevant data and materials technical specifications and ensure no Purchase Orders are past due in the ERP System.
• Management of purchased item Complaints/Returns to supplier.
• Reporting of technical complaints / adverse events / special case scenarios related to Novartis products within 24 hours of receipt -Distribution of marketing samples (where applicable) -Provide expertise and system support for returns, rebates and credit/debit notes -Define and decide on priorities for physical deliveries in collaboration with other functions (e.g. LEX) for 3rd party customers and cross divisional supplies -Act as SPOC for partner concern issues for assigned customers -Influencing and connecting relevant partners to speed up (system) issue resolution -Material Planner -Ensure management of daily MRP exception messages And appropriate follow up.
• Provide a load balanced dispatch list for incoming materials to the warehouse and Quality department that ensures these activities are completed in line with the production needs.

Essential Requirements:

• Collaborating across boundaries.
• Operations Management and Execution.
• Project Management.
• Inventory Management, Gap Analysis, Cost Efficiency and efficiency of supply processes -Standard Master Data KPIs e.g. Completeness, Consistency and Accuracy.

Desirable Requirements:

• Bachelor / Masters Degree with experience in Pharmaceutical Industry/ specifically GMP background.

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