thesis examples for biology

BIOLOGICAL SCIENCES MAJOR

Senior thesis examples.

Graduating seniors in Biological Sciences have the option of submitting a senior thesis for consideration for Honors and Research Prizes .  Below are some examples of particularly outstanding theses from recent years (pdf):

Sledd Thesis

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Molecular Biosciences Theses and Dissertations

Theses/dissertations from 2024 2024.

Androgen Drives Melanoma Invasiveness and Metastatic Spread by Inducing Tumorigenic Fucosylation , Qian Liu

Theses/Dissertations from 2023 2023

Exploring strain variation and bacteriophage predation in the gut microbiome of Ciona robusta , Celine Grace F. Atkinson

Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression , Janine M. DeBlasi

Thermodynamic frustration of TAD2 and PRR contribute to autoinhibition of p53 , Emily Gregory

Utilization of Detonation Nanodiamonds: Nanocarrier for Gene Therapy in Non-Small Cell Lung Cancer , Allan E. Gutierrez

Utilizing neoantigen-specific CD4* T cells and immune checkpoint modulation to advance adoptive cell therapy with tumor-infiltrating lymphocytes for metastatic melanoma patients , Maclean Scott Hall

Role of HLA-DRB1 Fucosylation in Anti-Melanoma Immunity , Daniel K. Lester

Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML , Christopher T. Letson

The Role of the DNA Helicase Rrm3 under Replication Stress , Julius Muellner

Regulated Intramembrane Proteolysis by M82 Peptidases: The Role of PrsS in the Staphylococcus aureus Stress Response , Baylie M. Schott

Histone Deacetylase 8 is a Novel Therapeutic Target for Mantle Cell Lymphoma and Preserves Natural Killer Cell Cytotoxic Function , January M. Watters

Theses/Dissertations from 2022 2022

Ceramide-1-Phosphate: A Novel Regulator of Golgi Fragmentation, Golgi-ER Vesicle Trafficking, and Anaplasma phagocytophilum Pathogenesis , Anika Nayar Ali

Regulation of the Heat Shock Response via Lysine Acetyltransferase CBP-1 and in Neurodegenerative Disease in Caenorhabditis elegans , Lindsey N. Barrett

Establishment of a Melanoma ESC-GEMM Platform and Its Use to Study PTEN Tumor Suppressor Functions , Ilah Bok

Adrenergic Modulation of Precursor Cells of Ovarian Cancer , Sweta Dash

Determining the Role of Dendritic Cells During Response to Treatment with Paclitaxel/Anti-TIM-3 , Alycia Gardner

To be or not to be: A Tale of Staphylococcal GpsB , Lauren R. Hammond

Origin and Epigenetic Regulation of Cutaneous T Cell Lymphoma , Carly M. Harro

Cell-free DNA Methylation Signatures in Cancer Detection and Classification , Jinyong Huang

The Role Of Eicosanoid Metabolism in Mammalian Wound Healing and Inflammation , Kenneth D. Maus

A Holistic Investigation of Acidosis in Breast Cancer , Bryce Ordway

Characterizing the Impact of Postharvest Temperature Stress on Polyphenol Profiles of Red and White-Fruited Strawberry Cultivars , Alyssa N. Smith

Identification of Secondary Structural Elements Contained Within the Intrinsically Disordered N-Terminal Tail of the Bloom’s Syndrome Helicase. , Vivek Somasundaram

Defining the role of Oxidized Mitochondrial DNA in Myelodysplastic Syndromes , Grace Anne Ward

Lord of the Z-rings: Uncovering the Role of MraZ and FtsL in Bacillus subtilis Cell Division , Maria Louise White

Theses/Dissertations from 2021 2021

Multifaceted Approach to Understanding Acinetobacter baumannii Biofilm Formation and Drug Resistance , Jessie L. Allen

Cellular And Molecular Alterations Associated with Ovarian and Renal Cancer Pathophysiology , Ravneet Kaur Chhabra

Ecology and diversity of boletes of the southeastern United States , Arian Farid

CircREV1 Expression in Triple-Negative Breast Cancer , Meagan P. Horton

Microbial Dark Matter: Culturing the Uncultured in Search of Novel Chemotaxonomy , Sarah J. Kennedy

The Multifaceted Role of CCAR-1 in the Alternative Splicing and Germline Regulation in Caenorhabditis elegans , Doreen Ikhuva Lugano

Unraveling the Role of Novel G5 Peptidase Family Proteins in Virulence and Cell Envelope Biogenesis of Staphylococcus aureus , Stephanie M. Marroquin

Cytoplasmic Polyadenylation Element Binding Protein 2 Alternative Splicing Regulates HIF1α During Chronic Hypoxia , Emily M. Mayo

Transcriptomic and Functional Investigation of Bacterial Biofilm Formation , Brooke R. Nemec

A Functional Characterization of the Omega (ω) subunit of RNA Polymerase in Staphylococcus aureus , Shrushti B. Patil

The Role Of Cpeb2 Alternative Splicing In TNBC Metastasis , Shaun C. Stevens

Screening Next-generation Fluorine-19 Probe and Preparation of Yeast-derived G Proteins for GPCR Conformation and Dynamics Study , Wenjie Zhao

Theses/Dissertations from 2020 2020

Understanding the Role of Cereblon in Hematopoiesis Through Structural and Functional Analyses , Afua Adutwumwa Akuffo

To Mid-cell and Beyond: Characterizing the Roles of GpsB and YpsA in Cell Division Regulation in Gram-positive Bacteria , Robert S. Brzozowski

Spatiotemporal Changes of Microbial Community Assemblages and Functions in the Subsurface , Madison C. Davis

New Mechanisms That Regulate DNA Double-Strand Break-Induced Gene Silencing and Genome Integrity , Dante Francis DeAscanis

Regulation of the Heat Shock Response and HSF-1 Nuclear Stress Bodies in C. elegans , Andrew Deonarine

New Mechanisms that Control FACT Histone Chaperone and Transcription-mediated Genome Stability , Angelo Vincenzo de Vivo Diaz

Targeting the ESKAPE Pathogens by Botanical and Microbial Approaches , Emily Dilandro

Succession in native groundwater microbial communities in response to effluent wastewater , Chelsea M. Dinon

Role of ceramide-1 phosphate in regulation of sphingolipid and eicosanoid metabolism in lung epithelial cells , Brittany A. Dudley

Allosteric Control of Proteins: New Methods and Mechanisms , Nalvi Duro

Microbial Community Structures in Three Bahamian Blue Holes , Meghan J. Gordon

A Novel Intramolecular Interaction in P53 , Fan He

The Impact of Myeloid-Mediated Co-Stimulation and Immunosuppression on the Anti-Tumor Efficacy of Adoptive T cell Therapy , Pasquale Patrick Innamarato

Investigating Mechanisms of Immune Suppression Secondary to an Inflammatory Microenvironment , Wendy Michelle Kandell

Posttranslational Modification and Protein Disorder Regulate Protein-Protein Interactions and DNA Binding Specificity of p53 , Robin Levy

Mechanistic and Translational Studies on Skeletal Malignancies , Jeremy McGuire

Novel Long Non-Coding RNA CDLINC Promotes NSCLC Progression , Christina J. Moss

Genome Maintenance Roles of Polycomb Transcriptional Repressors BMI1 and RNF2 , Anthony Richard Sanchez IV

The Ecology and Conservation of an Urban Karst Subterranean Estuary , Robert J. Scharping

Biological and Proteomic Characterization of Cornus officinalis on Human 1.1B4 Pancreatic β Cells: Exploring Use for T1D Interventional Application , Arielle E. Tawfik

Evaluation of Aging and Genetic Mutation Variants on Tauopathy , Amber M. Tetlow

Theses/Dissertations from 2019 2019

Investigating the Proteinaceous Regulome of the Acinetobacter baumannii , Leila G. Casella

Functional Characterization of the Ovarian Tumor Domain Deubiquitinating Enzyme 6B , Jasmin M. D'Andrea

Integrated Molecular Characterization of Lung Adenocarcinoma with Implications for Immunotherapy , Nicholas T. Gimbrone

The Role of Secreted Proteases in Regulating Disease Progression in Staphylococcus aureus , Brittney D. Gimza

Advanced Proteomic and Epigenetic Characterization of Ethanol-Induced Microglial Activation , Jennifer Guergues Guergues

Understanding immunometabolic and suppressive factors that impact cancer development , Rebecca Swearingen Hesterberg

Biochemical and Proteomic Approaches to Determine the Impact Level of Each Step of the Supply Chain on Tomato Fruit Quality , Robert T. Madden

Enhancing Immunotherapeutic Interventions for Treatment of Chronic Lymphocytic Leukemia , Kamira K. Maharaj

Characterization of the Autophagic-Iron Axis in the Pathophysiology of Endometriosis and Epithelial Ovarian Cancers , Stephanie Rockfield

Understanding the Influence of the Cancer Microenvironment on Metabolism and Metastasis , Shonagh Russell

Modeling of Interaction of Ions with Ether- and Ester-linked Phospholipids , Matthew W. Saunders

Novel Insights into the Multifaceted Roles of BLM in the Maintenance of Genome Stability , Vivek M. Shastri

Conserved glycine residues control transient helicity and disorder in the cold regulated protein, Cor15a , Oluwakemi Sowemimo

A Novel Cytokine Response Modulatory Function of MEK Inhibitors Mediates Therapeutic Efficacy , Mengyu Xie

Novel Strategies on Characterizing Biologically Specific Protein-protein Interaction Networks , Bi Zhao

Theses/Dissertations from 2018 2018

Characterization of the Transcriptional Elongation Factor ELL3 in B cells and Its Role in B-cell Lymphoma Proliferation and Survival , Lou-Ella M.m. Alexander

Identification of Regulatory miRNAs Associated with Ethanol-Induced Microglial Activation Using Integrated Proteomic and Transcriptomic Approaches , Brandi Jo Cook

Molecular Phylogenetics of Floridian Boletes , Arian Farid

MYC Distant Enhancers Underlie Ovarian Cancer Susceptibility at the 8q24.21 Locus , Anxhela Gjyshi Gustafson

Quantitative Proteomics to Support Translational Cancer Research , Melissa Hoffman

A Systems Chemical Biology Approach for Dissecting Differential Molecular Mechanisms of Action of Clinical Kinase Inhibitors in Lung Cancer , Natalia Junqueira Sumi

Investigating the Roles of Fucosylation and Calcium Signaling in Melanoma Invasion , Tyler S. Keeley

Synthesis, Oxidation, and Distribution of Polyphenols in Strawberry Fruit During Cold Storage , Katrina E. Kelly

Investigation of Alcohol-Induced Changes in Hepatic Histone Modifications Using Mass Spectrometry Based Proteomics , Crystina Leah Kriss

Off-Target Based Drug Repurposing Using Systems Pharmacology , Brent M. Kuenzi

Investigation of Anemarrhena asphodeloides and its Constituent Timosaponin-AIII as Novel, Naturally Derived Adjunctive Therapeutics for the Treatment of Advanced Pancreatic Cancer , Catherine B. MarElia

The Role of Phosphohistidine Phosphatase 1 in Ethanol-induced Liver Injury , Daniel Richard Martin

Theses/Dissertations from 2017 2017

Changing the Pathobiological Paradigm in Myelodysplastic Syndromes: The NLRP3 Inflammasome Drives the MDS Phenotype , Ashley Basiorka

Modeling of Dynamic Allostery in Proteins Enabled by Machine Learning , Mohsen Botlani-Esfahani

Uncovering Transcriptional Activators and Targets of HSF-1 in Caenorhabditis elegans , Jessica Brunquell

The Role of Sgs1 and Exo1 in the Maintenance of Genome Stability. , Lillian Campos-Doerfler

Mechanisms of IKBKE Activation in Cancer , Sridevi Challa

Discovering Antibacterial and Anti-Resistance Agents Targeting Multi-Drug Resistant ESKAPE Pathogens , Renee Fleeman

Functional Roles of Matrix Metalloproteinases in Bone Metastatic Prostate Cancer , Jeremy S. Frieling

Disorder Levels of c-Myb Transactivation Domain Regulate its Binding Affinity to the KIX Domain of CREB Binding Protein , Anusha Poosapati

Role of Heat Shock Transcription Factor 1 in Ovarian Cancer Epithelial-Mesenchymal Transition and Drug Sensitivity , Chase David Powell

Cell Division Regulation in Staphylococcus aureus , Catherine M. Spanoudis

A Novel Approach to the Discovery of Natural Products From Actinobacteria , Rahmy Tawfik

Non-classical regulators in Staphylococcus aureus , Andy Weiss

Theses/Dissertations from 2016 2016

In Vitro and In Vivo Antioxidant Capacity of Synthetic and Natural Polyphenolic Compounds Identified from Strawberry and Fruit Juices , Marvin Abountiolas

Quantitative Proteomic Investigation of Disease Models of Type 2 Diabetes , Mark Gabriel Athanason

CMG Helicase Assembly and Activation: Regulation by c-Myc through Chromatin Decondensation and Novel Therapeutic Avenues for Cancer Treatment , Victoria Bryant

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Home > Life Sciences > Microbiology and Molecular Biology > Theses and Dissertations

Microbiology and Molecular Biology Theses and Dissertations

Theses/dissertations from 2024 2024.

Characterization of Cellular Metabolism Regulation by the Transcription Factor Centromere Binding Factor 1 (Cbf1) , Spencer Ellsworth

Connecting HIV-1 Viral Protein R Polymorphisms to Changes in Inflammatory Signals and Efficacy Testing of Essential Oils as Disinfectants Against SARS-CoV-2 , J. Brandon Lopez

The Effects of Combining β-lactam Antibiotics and Mefloquine in Multi-Drug ResistantPseudomonas aeruginosa , Kayla C. Maas

Laying Framework for a Novel In Vitro Eukaryotic System to Measure Rate of Transcription Elongation , John Lucas Ramirez

Theses/Dissertations from 2023 2023

Elucidating the Architecture of the TclIJN Complex that Converts Cysteine to Thiazoles in the Biosynthesis of Micrococcin , Diana G. Calvopina Chavez

Manipulating and Assaying Chromatin Architecture Around Enhancer Elements in vivo , John Lawrence Carter

Using de novo Transcriptomes to Decipher the Relationships in Cutthroat Trout Subspecies (Oncorhynchus clarkii) , Andrea Leena Kokkonen

Characterization of Phage-Host Interactions and its Impact on Tail Fiber Evolution , Jessica Marie Lewis

Halophilic Genes that Impact Plant Growth in Saline Soils , Mckay A. Meinzer

Characterizing Stress Granule Regulation by PAS Kinase, Ataxin-2 and Ptc6 and Investigating the Lifespan of Covid-19 Virus on Currency , Colleen R. Newey

Changes in RNA Expression of HuT78 Cells Resulting From the HIV-1 Viral Protein R R77Q Mutation , Joshua S. Ramsey

Theses/Dissertations from 2022 2022

Biofilm Characterization and the Potential Role of eDNA in Horizontal Gene Transfer in Hospital and Meat Isolates of Staphylococcus aureus and Their Biofilms , Ashley Lynne Ball

Novel Patterns for Nucleosome Positioning: From in vitro to in vivo , David Andrew Bates

The Effects of Polymorphisms of Viral Protein R of HIV-1 on the Induction of Apoptosis in Primary Cells and the Characterization of Twelve Novel Bacillus anthracis Bacteriophage , Jacob D. Fairholm

Analysis of the Cytopathogenic Effect of Different HIV-1 Vpr Isoforms on Primary Human CD4+ T Cells and a Model Cell Line , Jonatan Josue Fierro Nieves

The Role of Chitinase A in Mastitis-Associated Escherichia coli Pathogenesis , Weston D. Hutchison

Big Data Meta-Analyses of Transcriptional Responses of Human Samples to Orthohantavirus Infection and Shotgun Metagenomics From Crohn's Disease Patients. , John L. Krapohl

An Exploration of Factors that Impact Uptake of Human Papillomavirus Vaccines , David Samuel Redd

Genomic Analysis and Therapeutic Development of Bacteriophages to Treat Bacterial Infections and Parasitic Infestations , Daniel W. Thompson

The Use of Nucleotide Salvage Pathway Enzymes as Suitable Tumor Targets for Antibody-Based and Adoptive Cell Therapies , Edwin J. Velazquez

Comparative Sequence Analysis Elucidates the Evolutionary Patterns of Yersinia pestis in New Mexico over Thirty-Two Years , M. Elizabeth Warren

Regulation of T Cell Activation by the CD5 Co-Receptor and Altered Peptides, Characterization of Thymidine Kinase-Specific Antibodies, and Integrating Genomics Education in Society , Kiara Vaden Whitley

Theses/Dissertations from 2021 2021

Evolution and Selection: From Suppression of Metabolic Deficiencies to Bacteriophage Host Range and Resistance , Daniel Kurt Arens

Identifying Sinorhizobium meliloti Genes that Determine Fitness Outcomes , Alexander B. Benedict

Pushing the Limits of SARS-CoV-2 Survival: How SARS-CoV-2 Responds to Quaternary Ammonium Compounds and Wastewater , Benjamin Hawthorne Ogilvie

Mutations in HIV-1 Vpr Affect Pathogenesis in T-Lymphocytes and Novel Strategies to Contain the Current COVID-19 Pandemic , Antonio Solis Leal

Theses/Dissertations from 2020 2020

Staphylococcus aureus Metal Acquisition in Milk and Mammary Gland Tissue , Shalee Killpack Carlson

Antimicrobial Peptide Development: From Massively Parallel Peptide Sequencing to Bioinformatic Motif Identification , Alexander K. Erikson

A Comparison of Chikungunya Virus Infection, Dissemination, and Cytokine Induction in Human and Murine Macrophages and Characterization of RAG2-/-γc-/- Mice as an Animal Model to Study Neurotropic Chikungunya Disease , Israel Guerrero

The Effects of Immune Regulation and Dysregulation: Helper T Cell Receptor Affinity, Systemic Lupus Erythematosus and Cancer Risk, and Vaccine Hesitancy , Deborah K. Johnson

Identification of Genes that Determine Fitness, Virulence, and Disease Outcomes in Mastitis Associated Eschericia coli , Michael Andrew Olson

Theses/Dissertations from 2019 2019

Investigation of Thymidine Kinase 1 in Cancer Progression , Eliza Esther King Bitter

Ribosomally Synthesized and Post-Translationally Modified Peptides as Potential Scaffolds for Peptide Engineering , Devan Bursey

Bioaerosols Associated with Evaporative Cooler Use in Low-Income Homes in Semi-Arid Climates , Ashlin Elaine Cowger

PAS Kinase and TOR, Controllers of Cell Growth and Proliferation , Brooke Jasmyn Cozzens

Regulation of Immune Cell Activation and Functionby the nBMPp2 Protein andthe CD5 Co-Receptor , Claudia Mercedes Freitas

Characterizing Novel Pathways for Regulation and Function of Ataxin-2 , Elise Spencer Melhado

Interactions Between the Organellar Pol1A, Pol1B, and Twinkle DNA Replication Proteins and Their Role in Plant Organelle DNA Replication , Stewart Anthony Morley

SNFing Glucose to PASs Mitochondrial Dysfunction: The Role of Two Sensory Protein Kinases in Metabolic Diseases , Kai Li Ong

Characterizing the Function of PAS kinase in Cellular Metabolism and Neurodegenerative Disease , Jenny Adele Pape

Isolation, Characterization, and Genomic Comparison of Bacteriophages of Enterobacteriales Order , Ruchira Sharma

Isolation, Genetic Characterization and Clinical Application of Bacteriophages of Pathogenic Bacterial Species , Trever Leon Thurgood

Investigation of Therapeutic Immune Cell Metabolism , Josephine Anna Tueller

Theses/Dissertations from 2018 2018

Innate Immune Cell Phenotypes Are Dictated by Distinct Epigenetic Reprogramming , Kevin Douglas Adams

Bacteriophages for Treating American Foulbrood and the Neutralization of Paenibacillus larvae Spores , Thomas Scott Brady

Methods for Detection of and Therapy for Carbapenem-Resistant Enterobacteriaceae , Olivia Tateoka Brown

The Diversity Found Among Carbapenem-Resistant Bacteria , Galen Edward Card

Exploration of Antimicrobial Activity in Natural Peptides and High-Throughput Discovery of Synthetic Peptides , Emma Kay Dallon

Gut Microbiota Regulates the Interplay Between Diet and Genetics to Influence Insulin Resistance , Jeralyn Jones Franson

The Antimicrobial Properties of Honey and Their Effect on Pathogenic Bacteria , Shreena Himanshu Mody

The Ability of Novel Phage to Infect Virulent Bacillus anthracis Isolates , Hyrum Smith Shumway

Galleria Mellonella as an Alternate Infection Model for Burkholderia Species and a Comparison of Suspension and Surface Test Methods for Evaluating Sporicidal Efficacy , Joseph D. Thiriot

The Clinical Significance of HPRT as a Diagnostic and Therapeutic Biomarker for Hematological and Solid Malignancies , Michelle Hannah Townsend

Biomarker Analysis and Clinical Relevance of Thymidine Kinase 1 in Solid and Hematological Malignancies , Evita Giraldez Weagel

Hospital and meat associated Staphylococcus aureus and Their Biofilm Characteristics , Trevor Michael Wienclaw

Theses/Dissertations from 2017 2017

Comparison of Cytokine Expression and Bacterial Growth During Periparturient and Mid Lactation Mastitis in a Mouse Model , Rhonda Nicole Chronis

Influence of Epstein-Barr Virus on Systemic Lupus Erythematosus Disease Development and the Role of Depression on Disease Progression , Caleb Cornaby

The Effects of Nucleosome Positioning and Chromatin Architecture on Transgene Expression , Colton E. Kempton

Phosphate Signaling Through Alternate Conformations of the PstSCAB Phosphate Transporter , Ramesh Krishna Vuppada

Acetobacter fabarum Genes Influencing Drosophila melanogaster Phenotypes , Kylie MaKay White

Theses/Dissertations from 2016 2016

The Path to Understanding Salt Tolerance: Global Profiling of Genes Using Transcriptomics of the Halophyte Suaeda fruticosa , Joann Diray Arce

Genetic and Biochemical Analysis of the Micrococcin Biosynthetic Pathway , Philip Ross Bennallack

Characterizing Interaction Between PASK and PBP1/ ATXN2 to Regulate Cell Growth and Proliferation , Nidhi Rajan Choksi

The Activity of Alkaline Glutaraldehyde Against Bacterial Endospores and Select Non-Enveloped Viruses , Justen Thalmus Despain

The Role of Viral Interleukin-6 in Tumor Development of Kaposi's Sarcoma-Associated Herpesvirus Lymphomas , Rebecca A. Fullwood

The Role of the Transcriptional Antiterminator RfaH in Lipopolysaccharide Synthesis, Resistance to Antimicrobial Peptides, and Virulence of Yersinia pseudotuberculosis and Yersinia pestis , Jared Michael Hoffman

A CryAB Interactome Reveals Clientele Specificity and Dysfunction of Mutants Associated with Human Disease , Whitney Katherine Hoopes

The pmrHFIJKLM Operon in Yersinia pseudotuberculosis Enhances Resistance to CCL28 and Promotes Phagocytic Engulfment by Neutrophils , Lauren Elizabeth Johnson

Characterization of Five Brevibacillus Bacteriophages and Their Genomes , Michael Allen Sheflo

Analysis of Nucleosome Isolation and Recovery: From In Silico Invitrosomes to In Vivo Nucleosomes , Collin Brendan Skousen

Human Herpesvirus 6A Infection and Immunopathogenesis in Humanized Rag2 -/-γc-/- Mice and Relevance to HIV/AIDS and Autoimmunity , Anne Tanner

Theses/Dissertations from 2015 2015

Identifying and Characterizing Yeast PAS Kinase 1 Substrates Reveals Regulation of Mitochondrial and Cell Growth Pathways , Desiree DeMille

The Detection and Molecular Evolution of Francisella tularensis Subspecies , Mark K. Gunnell

Isolation and Host Range of Staphylococcus aureus Bacteriophages and Use for Decontamination of Fomites , Kyle C. Jensen

The Antioxidant and DNA Repair Capacities of Resveratrol, Piceatannol, and Pterostilbene , Justin Ryan Livingston

High Salinity Stabilizes Bacterial Community Composition and Activity Through Time , Tylan Wayne Magnusson

Advancing Phage Genomics and Honeybee Health Through Discovery and Characterization of Paenibacillaceae Bacteriophages , Bryan Douglas Merrill

Specialized Replication Operons Control Rhizobial Plasmid Copy Number in Developing Symbiotic Cells , Clarice Lorraine Perry

Gene Networks Involved in Competitive Root Colonization and Nodulation in the Sinorhizobium meliloti-Medicago truncatula Symbiosis , Ryan D. VanYperen

Theses/Dissertations from 2014 2014

Snf1 Mediated Phosphorylation and Activation of PAS Kinase , Bryan D. Badal

Studies of PhoU in Escherichia coli: Metal Binding, Dimerization,Protein/Protein Interactions, and a Signaling Complex Model , Stewart G. Gardner

Pharmacologic Immunomodulation of Macrophage Activation by Caffeine , Ryan Perry Steck

Analysis of Nucleosome Mobility, Fragility, and Recovery: From Embryonic Stem Cells to Invitrosomes , Ashley Nicolle Wright

Enhancing Protein and Enzyme Stability Through Rationally Engineered Site-Specific Immobilization Utilizing Non-Canonical Amino Acids , Jeffrey Chun Wu

Theses/Dissertations from 2013 2013

Thymidine Kinase 1: Diagnostic and Prognostic Significance in Malignancy , Melissa Marie Alegre

Promoter Polymorphisms in Interferon Regulatory Factor 5 , Daniel N. Clark

Modulators of Symbiotic Outcome in Sinorhizobium meliloti , Matthew B. Crook

Evidences for Protein-Protein Interactions Between PstB and PhoU in the Phosphate Signaling Complex of Escherichia coli , Kristine Dawn Johns

Identification of the Binding Partners for HspB2 and CryAB Reveals Myofibril and Mitochondrial Protein Interactions and Non-Redundant Roles for Small Heat Shock Proteins , Kelsey Murphey Langston

A Quadruplex Real-Time PCR Assay for the Rapid Detection and Differentiation of the Burkholderia pseudomallei Complex: B. mallei , B. pseudomallei , and B. thailandensis , Chinn-woan Lowe

The Role of Nuclear BMP2 in the Cell Cycle and Tumorigenesis , Brandt Alan Nichols

Nuclear BMP2 and the Immune Response , Daniel S. Olsen

Hypersaline Lake Environments Exhibit Reduced Microbial Dormancy , Joshua Christopher Vert

Theses/Dissertations from 2012 2012

Characterization of the Cellular and Organellar Dynamics that Occur with a Partial Depletion of Mitochondrial DNA when Arabidopsis Organellar DNA Polymerase IB is Mutated , John D. Cupp

Effect of Antioxidants and Oxidative Stress on Different Cancer Cell Types , Gaytri Devi Gupta Elera

Effects of Chemical Stimulation and Tumor Co-Incubation on Macrophage Activation and Aggressiveness, Measured Through Phagocytosis and Respiratory Burst , Bo Marcus Gustafsson

Loss of the Lipopolysaccharide Core Biosynthesis rfaD Gene Increases Antimicrobial Chemokine Binding and Bacterial Susceptibility to CCL28 and Polymyxin: A Model for Understanding the Interface of Antimicrobial Chemokines and Bacterial Host Defense Avoidance Mechanisms , Cynthia S. Lew

Partial Characterization of the Antimicrobial Activity of CCL28 , Bin Liu

Characterizing the Role of HspB2 in Cardiac Metabolism and Muscle Structure Using Yeast and Mammalian Systems , Jonathan Paul Neubert

Humanized Mice as a Model to Study Human Viral Pathogenesis and Novel Antiviral Drugs , Freddy Mauricio Sanchez Tumbaco

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Thesis proposal example 2

Senior Honors Thesis Research Proposal

Albert B. Ulrich III Thesis Advisor: Dr. Wayne Leibel 11 September 1998

Introduction:

Neotropical fish of the family Cichlidae are a widespread and diverse group of freshwater fish which, through adaptive radiation, have exploited various niches in freshwater ecosystems. One such evolutionary adaptation employed by numerous taxa is miniaturization, an evolutionary process in which a large ancestral form becomes reduced in size to exploit alternative niches. A considerable amount of research has been conducted on the effects of miniaturization on amphibians (Hanken 1983), but although miniaturization has been found to occur in 85 species of freshwater South American fish, little has been done to investigate the effects which miniaturization imposes on the anatomy of the fish (Hanken and Wake 1993).

Background:

Evolution is the process by which species adapt to environmental stresses over time. Nature imposes various selective pressures on ecosystems causing adaptive radiation, where species expand and fill new niches. One such adaptation for a new niche is miniaturization. Miniaturization can be defined as “the evolution of extremely small adult body size within a lineage” (Hanken and Wake 1993). Miniaturization is observed in a variety of taxa, and evolutionary size decreases are observed in mammals and higher vertebrates, but it is more common and more pronounced in reptiles, amphibians and fish (Hanken and Wake 1993). Miniaturization evolved as a specialization which allowed the organisms to avoid selective pressures and occupy a new niche. Miniaturization as a concept is dependent on the phylogenetic assumption that the organism evolved from a larger predecessor. Over time, the miniature organism had to adapt to the new conditions as a tiny species. All of the same basic needs had to be met, but with a smaller body.

In miniature species there is a critical relationship between structure of the body and body size, and frequently this downsizing results in structural and functional changes within the animal (Harrison 1996). Within the concept of miniaturization is the assumption that the species evolved from a larger progenitor. It is necessary then to explore the effects of the miniaturization process. “Miniaturization involves not only small body size per se, but also the consequent and often dramatic effects of extreme size reduction on anatomy, physiology, ecology, life history, and behavior” (Hanken and Wake 1993).

Hanken and Wake 1993 found that the adult skulls of the salamander Thorius were lacking several bones, others were highly underdeveloped, and many species within the genus were toothless. Several invertebrate species display the wholesale loss of major organs systems as a result of the drastic reduction in body size (Hanken and Wake 1993). Hanken and Wake also have shown that morphological novelty is a common result of miniaturization. Morphological novelty, in essence, is the development of new structures in the miniature organism. For example, as body size decreases, certain vital organs will only be able to be reduced by a certain amount and still function. As a result organs such as the inner ear remain large relative to the size of the miniature skull, and structural innovations have to occur in order to support the proportionately large inner ear.

In 1983, James Hanken, at the University of Colorado determined that the adult skull of the Plethodontid salamanders could be characterized by three observations: 1) there was a limited development or even an absence of several ossified elements such as dentition and other bones; 2) there was interspecific and intraspecific variability; 3) there were novel mophological configurations of the braincase and jaw (Hanken 1983).

In his experiments, Hanken found that cranial miniaturization of the Thorius skull was achieved at the expense of ossification. Much of the ossified skeleton was lost or reduced, especially in the anterior elements, which are seen typically in larger adult salamanders (Hanken 1983). In contrast to this ossified downsizing, many of the sensory organs were not diminished in size — therefore present in greater proportion to the rest of the reduced head. He also reported that due to the geometrical space availability, there is a competition for space in reduced sized skulls, and the “predominant brain, otic capsules, and eyes have imposed structural rearrangements on much of the skull that remains” (Hanken 1983).

Hanken proposed that paedomorphosis was the mode of evolution of the plethodontid salamanders (Hanken 1983). Paedomorphosis is the state where the miniaturized structures of the adult salamanders can be described as arrested juvenile states. To support this theory, Hanken showed data where cranial skeletal reduction was less extreme in the posterior regions of the skull. One of the hallmarks of paedamorphosis is the lack of conservation in structures derived late in development. Early developed structures are highly conserved, and the latter derivations become either lost, or greatly reduced. Again, Hanken has shown that elements appearing late in development exhibit greater variation among species than do elements appearing earlier in ontogeny (Hanken 1983). But the presence of novel morphological features cannot be accounted for merely by truncated development and the retention of juvenile traits. Miniature Plethodontid salamanders display features that are not present in other species, juvenile or adult. These novel morphological features are associated with the evolution of decreased size and are postulated to compensate for the reductions occurring in other areas (Hanken 1983).

In 1985, Trueb and Alberch published a paper presenting similar results in their experiments with frogs. They explored the “relationships between body sizes of anurans and their cranial configurations with respect to the degree of ossification of the skull and two ontogenetic variables‹shape and number of differentiation events” (Trueb and Alberch 1985). Trueb and Alberch examined three morphological variables: size, sequence of differentiation events, and shape changes in individual structures. Size and snout length were measured, and the data showed that the more heavily ossified frogs tended to be smaller, whereas the less-ossified species were of average size, contrary to what was hypothesized. But Trueb and Alberch also attributed the diminution in size to paedomorphosis, citing that the smaller frogs lacked one or more of the elements typically associated with anuran skulls‹these missing elements were typically late in the developmental sequence. It is significant to note, however, that although there was an apparent paedomorphic trend, it could not be “applied unequivocally to all anuans” (Trueb and Alberch 1985). Very little research has been done on the effects of miniaturization on fish. In 1993, Buckup published a paper discussing the phylogeny of newly found minature species of Characidiin fish, but the extent of the examination was merely an acknowledgment that the species were indeed miniatures so that they could be taxonomically reclassified ( Buckup 1993). It is this deficit of knowledge with regard to miniaturization in fish that prompts this research.

Statement of the Problem:

How does miniaturization affect other vertebrates, such as fish? There are over 85 species of freshwater South American fish which are regarded as miniature, spanning 5 orders, 11 families and 40 genera (Hanken and Wake 1993). One such species, Apistogramma cacatuoides, is a South American Cichlid native to Peru. It lives in shallow water bodies in the rainforests, where miniature size is necessary. Males in this species reach approximately 8cm, and females only 5cm. This makes A. cacatuoides an ideal specimen for examination. In this senior honors thesis, I intend to examine the effects of miniaturization on cranial morphology of A. cacatuoides.

Plan of Research:

In this thesis, I will compare the cranial anatomy of A. cacatuoides to that of “Cichlasoma” (Archocentrus) nigrofasciatum, a commonly bred fish reared by aquarists known as the Convict Cichlid, a “typical” medium-sized cichlid also of South American origin. The Convicts will be examined at various stages in development, from juvenile to adult, and will be compared to A.cacatuoides.

The first part of this project will involve whole mount preparation of A. cacatuoides, utilizing the staining and clearing procedures described by Taylor and Van Dyke, 1985. This procedure involves the use of Alizarin Red and Alcian Blue to stain bone and cartilage, and takes into account the adaptations and recommendations Proposed in an earlier paper (Hanken and Wassersug 1981). The Taylor and Van Dyke procedure is specifically for the staining and clearing of small fish and other vertebrates. I tested the procedure during last semester¹s Independent Study and made a few minor adjustments to the protocol.

First, the specimens will be placed serially into an absolute ethyl alcohol solution and stained with Alcian Blue. The fish will then be neutralized in a saturated borax solution, transferred to a 20% hydrogen peroxide solution in potassium hydroxide, and then bleached under a fluorescent light. The unwanted soft tissues will then be cleared using trypsin powder, and then stained in KOH again with alizarin red. The final preparation of the fish involves rinsing the fish, and placing them serially into 40%, 70%, and finally 100% glycerin.

Following the above preparation of the specimens, the crania of the A. cacatuoides specimens will be examined for morphological variation and compared to the cranial anatomy of the Convict cichlid as a progenitor reference point examined at various developmental stages to see if paedomorphosis in indeed the mechanism of miniaturization in A. cacatuoides.

Expected Costs:

The project is estimated to cost no more that five hundred dollars for chemicals and supplies for the entire year.

Literature Cited:

Hanken, J., 1983. Miniaturization and its Effects on Cranial Morphology in Plethodontid Salamanders, Genus Thorius (Amphibia: Plethodontidae). I. Osteological Variation”. Biological Journal of the Linnean Society (London) 23: 55-75.

Hanken, James, 1983. Miniaturization and its Effects on Cranial Morhology in Plethodontid Salamanders, Genus Thorius (Amphibia, Plethodintidae): II.The Fate of the Brain and Sense Organs and Their Role in Skull Morphogenesis and Evolution . Journal of Morphology 177: 255-268.

Hanken, James and David Wake, 1993. Miniaturization of Body Size: Origanismal Consequences and Evolutionary Significance. Annual Review of Ecological Systems 24: 501-19.

Harrison, I. J., 1996. Interface Areas in Small Fish. Zoological Symposium No. 69. The Zoological Society of London: London.

Miller, P. J., 1996. Miniature Vertebrates: The Implications of Small Body Size. Symposium of the Zoological Society of London. No. 69: 15-45.

Taylor, William R. and George Van Dyke, 1985. Revised Procedures for Staining and Clearing Small Fishes and Other Vertebrates for Small Bone and Cartilage Study. Cybium. 9(2): 107-119.

Trueb, L. and P. Alberch, 1985. Miniaturization and the Anuran Skull: a Case Study of Heterochrony. Fortschritte der Zoologie. Bund 30.

Williams, T. Walley, 1941 Bone and Cartilage. Stain. Tech. 16:23-25.

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• Thesis Guidelines

A thesis for Distinction in Biology is a wonderful way for you to close the loop on your undergraduate research experience and showcase your scientific scholarship. Your thesis will be evaluated by the Faculty in Biology and answers the following questions: What did you do? Why did you do it? What is the significance of your results? What else would you do, were you to continue the project?

In answering the above questions, you have an opportunity to demonstrate your understanding and intellectual ownership of a project; not simply your productivity in the lab. The volume of results or completeness of the study is not critical for a successful thesis. Instead, we will be looking for the following:

• An argument for the significance of your research, contextualized within the scientific literature;
• A review of appropriate literature as evidence in support of claims you make in your argument;
• A statement of your research goals, i.e., a meaningful question of biological importance;
• A description of experimental approaches and methods ;
• Appropriate presentation of results through tables, figures, and images;
• A discussion of the meaning and significance of your results;
• A description of limitations and future directions for the project.

Expanded guidelines can be found in the Biology Thesis Assessment Protocol (BioTAP):

Format of the Thesis

The basic format of the thesis should resemble that of any scientific journal article that is common in your subdiscipline. It generally includes the following sections: Introduction & Background; Methods; Results; Discussion; Acknowledgements; and References. In some instances, it may be useful to sub-divide the Methods & Results section to correspond to multiple aims. However, if you chose to take this route, remember that there should still be a general Introduction and Discussion sections that address the project as a whole. The thesis should not consist of several "mini-papers" that are unconnected.  

Submission Guidelines

The format of the final copy should follow these guidelines:

• Cover Page ( sample ): Title; student's name; supervisor's name; date of submission; 3 signature lines at bottom right (Research Supervisor, DUS, Reader). Please follow the format and language of the sample.
• Abstract Page: single-spaced, roughly 250 words.
• Thesis should be double-spaced
• Pages should be numbered at the top right corner of the page
• It is preferred that figures are embedded within the document instead of all at the end
• There is no minimum page requirement or limit, although most are approximately 25 pages. 

Sample Theses

Examples of Distinction papers from previous years are available for examination in the Undergraduate Studies Office (Rm 135 BioSci).  Several samples are also available below as PDF files.

• Tracing the origins of antimalarial resistance in Plasmodium vivax
• Interaction network optimization improves the antimicrobial efficacy of phage cocktails
• Identifying how ufmylation of RAB1B regulates IFN-β signaling

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UKnowledge > College of Medicine > Microbiology, Immunology, and Molecular Genetics > Theses & Dissertations

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Theses/dissertations from 2024 2024.

AZITHROMYCIN ALCHEMY: A JOURNEY FROM PRECISION IMMUNOMODULATION TO TARGET EXPLORATION AND BEYOND , Hodaossadat Saghaeiannejad Esfahani

THE ROLE OF INTRACELLULAR GROWTH DURING THE SYSTEMIC SPREAD OF LISTERIA MONOCYTOGENES , Jamila S. Tucker

Theses/Dissertations from 2023 2023

Investigation of Key Mechanisms of Contact Dependent Growth Inhibition Systems in Burkholderia cepacia Complex Species , Zaria K. Elery

Investigating the relationship between metabolic reprogramming and peripheral CD4+ T-cell inflammation in human type 2 diabetes pathogenesis , Gabriella Kalantar

SUBSTRATE SELECTION AND EFFECTOR GATING IN THE HELICOBACTER PYLORI CAG TYPE IV SECRETION SYSTEM , Mackenzie E. Ryan

Theses/Dissertations from 2021 2021

APPLICATION OF GENETIC TECHNIQUES TO INVESTIGATE CHLAMYDIA TRACHOMATIS TYPE III SECRETION EFFECTOR BIOLOGY , Gabrielle Keb

CHARACTERIZING THE PHYSIOLOGY AND GENETICS OF CONTACT DEPENDENT GROWTH INHIBITON SYSTEMS IN BURKHOLDERIA SPECIES , Alice Elizabeth Oates

Theses/Dissertations from 2020 2020

Elucidating the Complex Signaling Events Driving Intestinal Stem Cell Plasticity Following Injury , Evan Lynch

MAST CELLS AS NOVEL EFFECTOR CELLS IN THE PATHOGENESIS OF CHRONIC GRAFT-VERSUS-HOST DISEASE , Ethan Strattan

Theses/Dissertations from 2019 2019

THE ROLE OF CD8 T CELL IMMUNODOMINANCE AND REGULATORY T CELLS IN NEONATAL IMMUNITY TO INFLUENZA VIRUS , Luke Heil

EVOLUTION OF THE ZHX TRANSCRIPTION FACTOR FAMILY AND ANALYSIS OF ZHX2 TARGET GENES CYP2A4 AND CYP2A5 IN MOUSE LIVER , Alexandra Nichole Nail

FUNCTIONAL ANALYSES OF THE DNA- AND RNA-BINDING PROTEIN SPOVG IN BORRELIA BURGDORFERI , Christina R. Savage

Theses/Dissertations from 2018 2018

INSIGHTS INTO KEY GENE REGULATORY NETWORKS IN BORRELIA BURGDORFERI , William Kenneth Arnold

THE ROLE OF PRO-INFLAMMATORY MEDIATORS IFNβ AND PROSTAGLANDIN E2 IN SUPPRESSION OF INNATE IMMUNITY TO LISTERIA MONOCYTOGENES , Michelle G. Pitts

Theses/Dissertations from 2017 2017

SUPPRESSION OF ANTI-TUMOR IMMUNITY IN CHRONIC LYMPHOCYTIC LEUKEMIA VIA INTERLEUKIN-10 PRODUCTION , Sara Alhakeem

ANTISENSE AFP TRANSCRIPTS IN MOUSE LIVER AND THEIR POTENTIAL ROLE IN AFP GENE REGULATION , Maria S. Dixon

IMMUNE EVASION BY DIVISION OF LABOR: THE TROPHIC LIFE CYCLE STAGE OF PNEUMOCYSTIS MURINA SUPPRESSES INNATE IMMUNITY TO THIS OPPORTUNISTIC, FUNGAL PATHOGEN , Heather M. Evans

ROLE OF INTRACELLULAR GROWTH DURING THE GASTROINTESTINAL STAGE OF LISTERIA MONOCYTOGENES INFECTION , Grant Steven Jones

NOVEL ROLE OF PROSTATE APOPTOSIS RESPONSE-4 TUMOR SUPPRESSOR IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA , Mary Kathryn McKenna

THERAPEUTIC POTENTIAL OF TARGETING REACTIVE OXYGEN SPECIES (ROS) STRESS IN MYELODYSPLASTIC SYNDROME (MDS) , Karine Z. Oben

Theses/Dissertations from 2016 2016

Expression of Zinc Fingers and Homeoboxes 2 (Zhx2) and Zhx2 Target Genes in Multiple Tissues of Wild-Type and Zhx2 Knockout Mice , Minen Al-Kafajy

Theses/Dissertations from 2015 2015

THE ROLE OF BATF2 IN LPS/IFNγ POLARIZED MACROPHAGES , Marie A. Gehman

Theses/Dissertations from 2013 2013

ON T CELL FATE DECISIONS: RETINOL, METABOLISM AND ITREG DIFFERENTIATION , Gavin I. Ellis

Theses/Dissertations from 2012 2012

Role of the Immune System and Bioactive Lipids in Trafficking Bone Marrow-Derived Stem Cells in Patients with Ischemic Heart Disease , Ahmed Abdel-Latif

INSIGHTS INTO HEPATIC ALPHA-FETOPROTEIN GENE REGULATION DURING LIVER DEVELOPMENT AND DISEASE , Erica Leigh Clinkenbeard

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Dedifferentiation of Cytotoxic Lympthocyte into Central Memory CD8+T Cells:  Lessons from Antiviral T-Stem Cells on the Architecture of Aging and Immunotherapy - Jonathan Johnnidis, Ph.D.

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Proteolytic Activation by ADAMTS3 Defines Distinct Mechanisms of Lymphangiogenesis Mediated by VEGFC and VEGFD - Hung Bui, Ph.D.

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The Role of Exocyst in Exocytosis and Cell Migration  - Jianglan Liu, Ph.D.

YY1 Controls Immunoglobulin Class Switch Recombination and Nuclear Aid Levels  - Kristina Zaprazna, Ph.D.

Mechanisms of HDAC2 Function in the Regulation of Adult Cardiac Hypertrophy and Embryonic Myocyte Proliferation  - Wenting Zhu, Ph.D.

Actin-Independent Mechanisms of Targeting Formin mDIA2 to the Plasma Membrane  - Roman Gorelik, Ph.D.

Roles of Protein Factors in Regulation of Imprinted Gene Expression  - Shu Lin, Ph.D.

Functional Plasticity of Hippocampal Glutamatergic Synapses in Development and Disease  - Xiaoyu Peng, Ph.D.

Physiological Bases of Plant Shrinkage and its Demographic Implications  - Roberto Salguero-Gomez, Ph.D.

Class of 2010  

Unplugged/Musk Signaling Coordinates Pre- and Post-synaptic Development at the Neuromuscular Junction  - Lili Jing, PhD

Spatially Varying Selection on Shell Color Phenotype in the Flat Periwinkle Littorina Obtusata  - Megan Phifer-Rixey, PhD

Niche Partitioning Among Arbuscular Mycorrhizal Fungi and Consequences for Host Plant Performance  - Jennifer H. Doherty, PhD

Microrna Pathways Modulate Aging and Neurodegenerative Diseases  - Nan Liu, PhD

The Rab3A Locus: Studies of Neuronal Expression and Effects on Behavior  - Rui Liu, PhD

The Evolutionary Genetics of Life History in Drosophila Melanogaster  - Annalise Bloss Paaby, PhD

Using Evolutionary Genomics to Elucidate Parasite Biology and Host-Pathogen Interactions  - Lucia Peixoto, PhD

Class of 2009  

Characterizing the Role of the Exocyst Component EX070 in Exocytosis and Actin Dynamics in Budding Yeast Saccharomyces Cerevisiae  - Bing He, PhD

Slit Down-Regulates CRGAP Function to Mediate Axon Repulsion in the Embryonic Drosphila CNS  - Ming Li, PhD

Molecular Basis of Chve Function in Sugar Binding and Virulence in Agrobacterium Tumefaciens  - Fanglian He, PhD

Spatial and Temporal Variation in Streambed Bacterial Community Composition and Correlation with Einvironmental Variables and Disturbance  - Karen Rowley Hogan, PhD

Squint, The Arabidopsis   Ortholog of Cyclophilin40, Affects RNA Silencing  - Michael Smith, PhD

Spatial Regulation of CDC42 by its GTPase-Activating Proteins RGA1 and BEM2 in Budding Yeast Saccharomyces Cerevisiae  - Zongtian Tong, PhD

Class of 2008

Molecular and Cellular Mechanism of Axon Guidance During Visual System Development in Zebrafis h - Michael Gyda, PhD

Phylogeny and Evolution of Prokaryotic Genomes  - Fan Ge, PhD

The Role of the Exocyst Complex in Polarized Exocytosis  - Puyue Wang, PhD

Evolutionary Ecology of Host Plant Use by an Insect Herbivore in a Highly Seasonal Neotropical Dry Forest  - Salvatore Agosta, PhD

Variation Among Dogwhelks (Nucella lapillus) Modifies Predator-prey Interactions within Intertidal Assemblages  - Jonathan Fisher, PhD

Peeking into the Black Box: The Structure and Function of Soil Microbial Communities in Response to Increasing Nitrogen Availability  - Richard Lucas, PhD

Taxonomic and Functional Diversity of AM Fungi in Serpentine and Prairie Grasslands  - Baoming Ji, PhD

Dissecting Different Modules of Cytochrome C Maturation in Rhodobacter Capsulatu s - Serdar Turkarslan, PhD

Role of Exocytosis in Cell Polarization  - Xiaoli Sun, PhD

Class of 2007

The Analysis of the PI3K/AKT Pathway in Human Ovarian Cancer with a Combination of Genomic and Genetic Appoaches  - Jia Huang, PhD

Examination of the Twin-Arginine Translocation Pathway in Bacteria and Archaea  - Kieran Dilks, PhD

Spatial Orientation in Columbian Ground Squirrels (Spermophilus Columbianus)  - Anna Vlasak, PhD

From Protein to RNA: Study of SCA3 Polyglutamine Disease in Drosophila   - Lingbo Li, PhD

Novel Insignts Into Vir Gene Regulation in Agrobacterium Tumefaciens  - Gauri Nair, PhD

Spatial and Genetic Patterns of Crane Flies (Diptera: Tipuloidea) from Lake Hovsgol Region, Mongolia  - Bazartseren Boldgiv, PhD

Aging in Plants at Multiple Scales  - Lori Spindler, PhD

Metabolic Pool, Metabolic Rates and Diapause in Drosophila Melanogster  - Christine Wills, PhD

Phylogenetics and Diversification of the Neotropical Serrasalminae (Ostariophysi: Characiformes)  - Wasila Dahdal, PhD

St Andrews Research Repository

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Biology Masters Theses

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The School promotes an interdisciplinary approach to both applied and fundamental research problems and to postgraduate training. Research in the School is organised into three major interdisciplinary centres: the Scottish Oceans Institute (SOI), Biomedical Sciences Research Complex (BSRC) and Centre for Biological Diversity (CBD). Together these centres encompass the full spectrum of research in biological sciences, spanning investigations on the properties and behaviour of individual molecules to planetary environmental dynamics.

For more information please visit the School of Biology home page.

This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.

Recent Submissions

Social plasticity within and across generations : testing the role of plasticity in rapid evolution in field cricket teleogryllus oceanicus , rhythmically repeated patterns of pulsed vocalizations in wild narwhals (monodon monoceros) , factors influencing growth and spore germination of species of boletus , density estimation and time trend analysis of large herbivores in nagarhole, india , designing a shipboard line transect survey to estimate cetacean abundance off the azores archipelago, portugal .

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Biology Thesis Examples & Study Documents

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Pros and Cons of Modern Medicine

Just like any other types of medicines, modern medicines provide both pros…

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World War II influence on the growth and development of California

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Diet and Fitness Plan

(OK). However, the total grains were (11+4 ½) 15 ½ ounces which…

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Yellow Fever Essay

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Blood Tracer Report

The aorta branches into left and right iliac arteries as they descend…

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Composing food waste Research

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Causes and Risk Factors for Developing a Brain Infection

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Life on Planet Mars

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The Morality of Animal Experimentation

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Microbicidal effects of Plain soap

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Aint I a Woman Response

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Genetic Traits Gene Structure and Mendels Principle

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Biology Report

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The nervous system and the endocrine system

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Global water issues and desalination

Water is life and the body of a human being is made…

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Assesing the safety of genetically modified foods

The World Health Organization (WHO) (2014) defines a genetically modified organism (GMO)…

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Essay on Mutagenesis

Gene mutation comprises changes in one or more nucleotides in a DNA…

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Human Nutrition report

Michael should be put on weight management diet that would help him…

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Literature Review of Biomimicry in Textile Finishes

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In the unlikely event of a water landing analysis

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Myosin Review Thesis

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Helminths in Humans

It’s surprising how these worms can live and adapt in an immune…

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3D printing Technology

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Algae Cultivation Lab Report

They are similarly normal in water as ashore. They contrast from different…

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Epigenetic transmission across generation

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GMOs in the Developing Third World Countries

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Apoptosis in Jurkat cells lab report

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Chemoreception The Science of Smell and Taste

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The brain and the nervous system report

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Antimicrobial susceptibility of plant extracts against human dental caries pathogen

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Human anatomy essay

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Technologies in cell theory

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Engineering probiotics to produce short chain fatty acids for the management of metabolic syndrome

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Antimicrobial susceptibility of some plant extracts against human dental caries pathogen

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Effects of sunscreen and cosmetics on coral reefs

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Staph and streph lab report

Various tests were carried out to identify the specific strain of bacteria…

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Comparison of foraging of canada goose and brant goose at different locations

The levels of forage quality and macronutrients vary among the turf grass…

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Health effects of fast foods

On the other hand, urbanization and globalization have significantly affected people's consumption…

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The circulatory system essay

Aronow, 2013, p. Atherosclerosis can easily cause death through a heart attack…

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Population growth reduction in the us

According to the famous theorist Thomas Malthus, population figures tend to grow…

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Asthma pathogens report

The pathogens come in diverse forms like bacterial and viral pathogens which…

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Tuberculosis pathogenic analysis

Tuberculosis (TB) is an infectious disease contributing to high mortality rate in…

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Genetics of dog breeding

According to the research by Brian Hare, a German researcher, the convergent…

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Organic food production

Many consumers are oversensitive about the quality of food, the production processes…

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Reoviridae dsrna viruses

When they were first discovered, they were not associated with any disease,…

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Surgery of the cornea

The cornea is the transparent covering of the pupil and the iris…

Summary of bmc cancer

” General background about the disease Breast cancer can take too long before…

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Cloning essay

Cell cloning creates copies of cell fragments of DNA, reproductive cloning generates…

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Water pollution and cleanup efforts

Modern decontamination tech may be specific to a contaminant or a group…

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Example Dissertation Titles

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• For Postgraduates
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Major subjects

Biochemistry.

Do histone modifications control gene expression?

Does endotoxin cause or contribute to neurodegenerative diseases?

Molecular interactions of drugs with the allosteric sites of vertebrate Cys-loop receptors

Why do bacteria carry toxin-antitoxin systems?

Aneuploidy in cancer: lessons so far

Big data in genomics and healthcare and how it has defined cancer diagnosis and treatment

Modelling in Biology: accurate descriptions of our pathetic thinking or pathetic descriptions of the real world?

Trace the economic and biological causes of the current antibiotic resistance crisis. Is there a solution and, if so, does it lie in the hands of patients, clinicians, regulators or researchers?

Transposable elements – a powerful force driving evolution

Can the gut microbiota influence host appetite? Implications for the aetiology of obesity

Can vaccine innovation solve the last mile problem for vaccines in low-resource settings

Eradication of Polio: Past Challenges and Future Prospects

Is the age of antibiotics over?

Microbiome regulation of the gut-brain axis: implications for anxiety and depression

On the origin of the bacterial flagellum: an example of irreducible complexity?

Recent advances in the blockade of immune checkpoints in cancer immunotherapy

What are the major causes of delay in response to emerging disease outbreaks: the case of the 2014-2016 Ebola outbreak in West Africa

Pharmacology

Cystic-fibrosis related diabetes

How do SNAREs mediate membrane fusion?

Is CRISPR ready for the clinic?

Phantom pain: a ghost in the machine or a biological basis?

Plant-derived polysaccharides - sweet medicine of tomorrow?

Why are opioids problematic analgesics?

Plant Sciences

"Scrambled Genomes": examining the methodology and goals of the Sc2.0 synthetic genome project

Engineering C4 Rice: Molecular Targets and Progress so far

Is Trehalose-6-phosphate a central regulator of plant carbon partitioning?

Sucrose signalling and its role in plant development

Who needs cells anyway?

Is visual adaptation diminished in autism spectrum disorders?

Memory reconsolidation blockade: a novel treatment for Post-Traumatic Stress Disorder

Parental influence on child language development: does gender matter?

Sleep disorders as model for Consciousness Research: a cognitive framework for parasomnias

The role of genetics in the transgenerational transmission of memories

The role of insulin in cognitive decline in the elderly

Physiology, Development and Neuroscience

Adaptations of cancer cells for metastasis to the brain

How and why is the infant gut microbiota affected by caesarean section? The crying need for well-designed research

How do astrocytes support and modulate neuronal function? Exploring neurovascular coupling, neurometabolic coupling, and gliotransmission

The missing nuances of science and society: How popular science is shaping policy and understanding

The role of operant conditioning in spinal cord plasticity and its potential therapeutic implications for spinal cord injury

The significance of proinflammatory mediators in disrupting HRV: a link to cardiovascular morbidity in schizophrenia?

Psychology, Neuroscience and Behaviour

Prenatal stress: relevance to major depressive disorder

Promises and limitations of a combinatorial approach to spinal cord injury

Social neurons? A critical examination of how individual neurons might implement primate social cognition

The bidirectional relationship between the hippocampus and metabolic syndrome

The Cognitive and Neurobiological Benefits of an Imperfect Memory

Why are drug seeking habits maladaptive?

How have homosexual mating preferences evolved in males and females?

How relevant is the Drosophila segmentation paradigm to the study of segmentation in other arthropods and other animals?

Mechanisms of mass extinction

Migration of Homo erectus out of Africa

The meaning of alarm calls: honesty and deception

Wolves verses Eurasian Lynx as candidates for large predator reintroduction in mainland Britain - which may be the most suitable and why?

Minor subjects

Conservation science.

Causes and remedies for the decline in red squirrel numbers in Britain

How do deer impact forest organisms in UK lowland woodland?

Reintroduction and translocation as conservation tools for rhinos

Translocation as a tool for tiger ( Panthera tigris ) conservation: problems and potential solutions

With respect to myxomatosis and RHD virus how have rabbit populations co-evolved with the viruses and how may rabbit populations be affected in the future?

Development and Psychopathology

To what extent have biasing in screening and diagnosis contributed to the sex ratios observed in autism?

Health, Medicine and Society

Medicalisation and violence against women: implications for the medical encounter

Human Ecology and Behaviour

The use of wood in prehistory

Neural Degeneration and Regeneration

Progress towards establishing lead times of biomarkers for early diagnosis of idiopathic Parkinson's disease

The Pharmacological Targeting of the Amyloid-beta pathway in Alzheimer's: issues and prospects

Philosophy and Ethics of Medicine

Dementia: how changing perspectives affect clinical decision making

Should the MMR vaccine be mandatory? The problem of herd immunity threshold

Psychology and Social Issues

Reducing Extremist Violence by increasing Integrative Complexity - why understanding the role of emotion is central to success

Information contacts

For information regarding Major Subjects such as content and timetables, please see the contact details on the Major Subjects webpage .

For information regarding Minor Subjects such as content and timetables, please see the contact details on the Minor Subjects webpage .

For general administration of BBS and general questions which cannot be answered in departments, please contact the Faculty of Biology Office ( [email protected] )

If you wish to move to or from BBS or wish to change Major and/or Minor subject(s), please contact the departments involved AND the Faculty of Biology Office.

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Writing Tips and Examples

Writing tips for grants & thesis dissertations, from the duke department of medicine:.

The Department of Medicine's vice chair for faculty development and diversity has collected a number of grant writing resources and successful sample grants that are available for review by Duke faculty and trainees. Follow the link below to view a list of resources - log into Duke Box  using your Duke Net ID and password and click a link below to access the documents.  Note: Do no use anyone else's text without permission.

• https://medicine.duke.edu/research/research-resources/templates-and-examples

Making a Poster: 

making_a_poster.pdf

Powerpoint Presentation Design: 

powerpointpresentation.pdf

Research Paper Writing: 

writing_a_research_paper.pdf

On NSF Grants:

Full NSF Proposal Example 2010

Sample Grant Proposals - Indiana University

• From the National Science Foundation: " A Guide for Proposal Writing "
• From National Science Foundation: " How to Get NSF Funding: A View from the 'Inside' "
• From Carnegie Mellon University: " Advice on Writing Proposals to the National Science Foundation "
• From the Principal Investigator's Association: " Executive Report: How to Write a Winning NSF Proposal "
• From Sunshine Consultants Int'l: " Writing a Compelling Grant Proposal to NSF "
• " Writing an NSF Grant Proposal: A First Timer's Perspective " by Philip J. Guo, Associate Professor @ UC San Diego

On NRSA Grants:

• From Science Direct: A Practical Guide to Writing a Ruth L. Kirschstein NRSA Grant
• From Illinois University: How to Win an NIH/Kirschstein/F30-F31 Predoctoral Fellowship - The Nuts & Bolts
• How to Write an F30 - Sidenote, Tumblr
• Thoughts on Writing an F31 NRSA Award - University of Pittsburgh School of Medicine
• From the University of Colorado: Sample NRSA Proposals

T32 Training Grants - Unlocking the Mystery - UNC Chapel Hill

• From the Burroughs Wellcome Fund & Howard Hughes Medical Institute: " Making the Right Moves: A Practical Guide to Scientific Management for Postdocs & New Faculty "

Skip to Content

• Undergraduate
• Honors Thesis Examples

EBIO student's Honors Thesis submissions from past years are archived here with abstracts from the student's respective papers. Peruse several of the submissions to get a sense of the area's of study our students delve into for their Honors Thesis projects.

Landscape Patterns of Litter Decomposition in Alpine Tundra - H. A. O'Lear and T. R. Seastedt - 1994

Effects of Mobile Tree Islands on Soil Carbon Storage in Tundra Ecosystems - Sheridan J. Pauker and T. R. Seastedt - 1996

Effects of Sequestered Iridoid Glycosides on Prey Choice of the Prairie Wolf Spider,  Lycosa carolinensis  - Demetri Hilario Theodoratus and M. Deane Bowers - 1998

Effects of Soil Nitrogen Reduction on Nonnative Plants in Restored Grasslands - K.J. Reever Morghan & T. R. Seastedt - 1999

Phylogeny of hammerhead sharks (Family Sphyrnidae) inferred from mitochondrial and nuclear genes -  Douglas D. Lim, Philip Motta, Kyle Mara, Andrew P. Martin - 2010

Beyond immunity: quantifying the efects of host anti-parasite behavior on parasite transmission -  Elizabeth W. Daly & Pieter T. J. Johnson - 2011

Land Use and Wetland Spatial Position Jointly Determine Amphibian Parasite Communities - Richard B. Hartson,  Sarah A. Orlofske,  Vanessa E. Melin,  Robert T. Dillon Jr., and Pieter T. J. Johnson - 2011

Effects of fuels reductions on plant communities and soils in a Piñon-juniper woodland - M.R. Ross, S.C. Castle, N.N. Barger - 2012

Investigating the dispersal routes used by an invasive amphibian, Lithobates catesbeianus , in human-dominated landscapes - Anna C. Peterson & Katherine L. D. Richgels & Pieter T. J. Johnson & Valerie J. McKenzie - 2012

Incorporation of an Introduced Weed into the Diet of a Native Butterfly: Consequences for Preference, Performance and Chemical Defense - Angela Knerl & M. Deane Bowers 

Quantifying the biomass of parasites to understand their role in aquatic communities - Jason Lambden & Pieter T. J. Johnson - 2013

Conceptual Revision and Synthesis of Proximate Factors Associated with Age-Related Improvement in Reproduction - Rachel J Bradley & Rebecca J. Safran - 2014

Patterns and ecological predictors of age-related performance in female North American barn swallows,  Hirundo rustica erythrogaster    -  R. J. Bradley & J. K. Hubbard & B. R. Jenkins & R. J. Safran - 2014

Assessing The Harmful Impacts Of Increased Commercial Shipping On Arctic Marine Mammals: A Systematic Literature Review - Hayley Wuestenberg - 2021

June 27, 2021

Read more about Assessing The Harmful Impacts Of Increased Commercial Shipping On Arctic Marine Mammals: A Systematic Literature Review - Hayley Wuestenberg - 2021

Harmful Algal Blooms As A Possible Cause Of Late Cretaceous Vertebrate Mortality Events In Northwestern Madagascar - Christopher Mulligan - 2021

Read more about Harmful Algal Blooms As A Possible Cause Of Late Cretaceous Vertebrate Mortality Events In Northwestern Madagascar - Christopher Mulligan - 2021

Population Structure Of The Endangered Mud Shrimp Upogebia Pugettensis - Madeleine Horan - 2021

Read more about Population Structure Of The Endangered Mud Shrimp Upogebia Pugettensis - Madeleine Horan - 2021

Exploring The Biogeographic Relationship Between Variation In Parasites And Pathogens And Host Plant Dispersal Traits - Patrick Heffernan - 2021

Read more about Exploring The Biogeographic Relationship Between Variation In Parasites And Pathogens And Host Plant Dispersal Traits - Patrick Heffernan - 2021

Flowering Time And Related Genes In Cannabis - Zachary Girard - 2021

Read more about Flowering Time And Related Genes In Cannabis - Zachary Girard - 2021

May Physical Activity Ameliorate Symptoms And Comorbidities Associated With Human Immunodeficiency Virus (Hiv) Infection? - Elizabeth Enichen - 2021

Read more about May Physical Activity Ameliorate Symptoms And Comorbidities Associated With Human Immunodeficiency Virus (Hiv) Infection? - Elizabeth Enichen - 2021

Nest Insulative Capacity Varies Between Chickadee Species But Not Along An Elevation Gradient - Shay Ding - 2021

Read more about Nest Insulative Capacity Varies Between Chickadee Species But Not Along An Elevation Gradient - Shay Ding - 2021

The Impact Of Early Snowmelt, Warming, And Microtopography On In Situ Geum Rossii Germination Rates In The Alpine - Nyika Campbell - 2021

Read more about The Impact Of Early Snowmelt, Warming, And Microtopography On In Situ Geum Rossii Germination Rates In The Alpine - Nyika Campbell - 2021

Entomology Education Since 2000: Methods, Outcomes, Challenges, and Suggestions for Practice - Elizabeth Woolner - 2020

Dec. 3, 2020

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Biology Hypothesis

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Delve into the fascinating world of biology with our definitive guide on crafting impeccable hypothesis thesis statements . As the foundation of any impactful biological research, a well-formed hypothesis paves the way for groundbreaking discoveries and insights. Whether you’re examining cellular behavior or large-scale ecosystems, mastering the art of the thesis statement is crucial. Embark on this enlightening journey with us, as we provide stellar examples and invaluable writing advice tailored for budding biologists.

What is a good hypothesis in biology?

A good hypothesis in biology is a statement that offers a tentative explanation for a biological phenomenon, based on prior knowledge or observation. It should be:

• Testable: The hypothesis should be measurable and can be proven false through experiments or observations.
• Clear: It should be stated clearly and without ambiguity.
• Based on Knowledge: A solid hypothesis often stems from existing knowledge or literature in the field.
• Specific: It should clearly define the variables being tested and the expected outcomes.
• Falsifiable: It’s essential that a hypothesis can be disproven. This means there should be a possible result that could indicate the hypothesis is incorrect.

What is an example of a hypothesis statement in biology?

Example: “If a plant is given a higher concentration of carbon dioxide, then it will undergo photosynthesis at an increased rate compared to a plant given a standard concentration of carbon dioxide.”

In this example:

• The independent variable (what’s being changed) is the concentration of carbon dioxide.
• The dependent variable (what’s being measured) is the rate of photosynthesis. The statement proposes a cause-and-effect relationship that can be tested through experimentation.

100 Biology Thesis Statement Examples

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Biology, as the study of life and living organisms, is vast and diverse. Crafting a good thesis statement in this field requires a clear understanding of the topic at hand, capturing the essence of the research aim. From genetics to ecology, from cell biology to animal behavior, the following examples will give you a comprehensive idea about forming succinct biology thesis statements.

Genetics: Understanding the role of the BRCA1 gene in breast cancer susceptibility can lead to targeted treatments.

2. Evolution: The finch populations of the Galápagos Islands provide evidence of natural selection through beak variations in response to food availability.

3. Cell Biology: Mitochondrial dysfunction is a central factor in the onset of age-related neurodegenerative diseases.

4. Ecology: Deforestation in the Amazon directly impacts global carbon dioxide levels, influencing climate change.

5. Human Anatomy: Regular exercise enhances cardiovascular health by improving heart muscle function and reducing arterial plaque.

6. Marine Biology: Coral bleaching events in the Great Barrier Reef correlate strongly with rising sea temperatures.

7. Zoology: Migration patterns of Monarch butterflies are influenced by seasonal changes and available food sources.

8. Botany: The symbiotic relationship between mycorrhizal fungi and plant roots enhances nutrient absorption in poor soil conditions.

9. Microbiology: The overuse of antibiotics in healthcare has accelerated the evolution of antibiotic-resistant bacterial strains.

10. Physiology: High altitude adaptation in certain human populations has led to increased hemoglobin production.

11. Immunology: The role of T-cells in the human immune response is critical in developing effective vaccines against viral diseases.

12. Behavioral Biology: Birdsong variations in sparrows can be attributed to both genetic factors and environmental influences.

13. Developmental Biology: The presence of certain hormones during fetal development dictates the differentiation of sex organs in mammals.

14. Conservation Biology: The rapid decline of bee populations worldwide is directly linked to the use of certain pesticides in agriculture.

15. Molecular Biology: The CRISPR-Cas9 system has revolutionized gene editing techniques, offering potential cures for genetic diseases.

16. Virology: The mutation rate of the influenza virus necessitates annual updates in vaccine formulations.

17. Neurobiology: Neural plasticity in the adult brain can be enhanced through consistent learning and cognitive challenges.

18. Ethology: Elephant herds exhibit complex social structures and matriarchal leadership.

19. Biotechnology: Genetically modified crops can improve yield and resistance but also pose ecological challenges.

20. Environmental Biology: Industrial pollution in freshwater systems disrupts aquatic life and can lead to loss of biodiversity.

21. Neurodegenerative Diseases: Amyloid-beta protein accumulation in the brain is a key marker for Alzheimer’s disease progression.

22. Endocrinology: The disruption of thyroid hormone balance leads to metabolic disorders and weight fluctuations.

23. Bioinformatics: Machine learning algorithms can predict protein structures with high accuracy, advancing drug design.

24. Plant Physiology: The stomatal closure mechanism in plants helps prevent water loss and maintain turgor pressure.

25. Parasitology: The lifecycle of the malaria parasite involves complex interactions between humans and mosquitoes.

26. Molecular Genetics: Epigenetic modifications play a crucial role in gene expression regulation and cell differentiation.

27. Evolutionary Psychology: Human preference for symmetrical faces is a result of evolutionarily advantageous traits.

28. Ecosystem Dynamics: The reintroduction of apex predators in ecosystems restores ecological balance and biodiversity.

29. Epigenetics: Maternal dietary choices during pregnancy can influence the epigenetic profiles of offspring.

30. Biochemistry: Enzyme kinetics in metabolic pathways reveal insights into cellular energy production.

31. Bioluminescence: The role of bioluminescence in deep-sea organisms serves as camouflage and communication.

32. Genetics of Disease: Mutations in the CFTR gene cause cystic fibrosis, leading to severe respiratory and digestive issues.

33. Reproductive Biology: The influence of pheromones on mate selection is a critical aspect of reproductive success in many species.

34. Plant-Microbe Interactions: Rhizobium bacteria facilitate nitrogen fixation in leguminous plants, benefiting both organisms.

35. Comparative Anatomy: Homologous structures in different species provide evidence of shared evolutionary ancestry.

36. Stem Cell Research: Induced pluripotent stem cells hold immense potential for regenerative medicine and disease modeling.

37. Bioethics: Balancing the use of genetic modification in humans with ethical considerations is a complex challenge.

38. Molecular Evolution: The study of orthologous and paralogous genes offers insights into evolutionary relationships.

39. Bioenergetics: ATP synthesis through oxidative phosphorylation is a fundamental process driving cellular energy production.

40. Population Genetics: The Hardy-Weinberg equilibrium model helps predict allele frequencies in populations over time.

41. Animal Communication: The complex vocalizations of whales serve both social bonding and long-distance communication purposes.

42. Biogeography: The distribution of marsupials in Australia and their absence elsewhere highlights the impact of geographical isolation on evolution.

43. Aquatic Ecology: The phenomenon of eutrophication in lakes is driven by excessive nutrient runoff and results in harmful algal blooms.

44. Insect Behavior: The waggle dance of honeybees conveys precise information about the location of food sources to other members of the hive.

45. Microbial Ecology: The gut microbiome’s composition influences host health, metabolism, and immune system development.

46. Evolution of Sex: The Red Queen hypothesis explains the evolution of sexual reproduction as a defense against rapidly evolving parasites.

47. Immunotherapy: Manipulating the immune response to target cancer cells shows promise as an effective cancer treatment strategy.

48. Epigenetic Inheritance: Epigenetic modifications can be passed down through generations, impacting traits and disease susceptibility.

49. Comparative Genomics: Comparing the genomes of different species sheds light on genetic adaptations and evolutionary divergence.

50. Neurotransmission: The dopamine reward pathway in the brain is implicated in addiction and motivation-related behaviors.

51. Microbial Biotechnology: Genetically engineered bacteria can produce valuable compounds like insulin, revolutionizing pharmaceutical production.

52. Bioinformatics: DNA sequence analysis reveals evolutionary relationships between species and uncovers hidden genetic information.

53. Animal Migration: The navigational abilities of migratory birds are influenced by magnetic fields and celestial cues.

54. Human Evolution: The discovery of ancient hominin fossils provides insights into the evolutionary timeline of our species.

55. Cancer Genetics: Mutations in tumor suppressor genes contribute to the uncontrolled growth and division of cancer cells.

56. Aquatic Biomes: Coral reefs, rainforests of the sea, host incredible biodiversity and face threats from climate change and pollution.

57. Genomic Medicine: Personalized treatments based on an individual’s genetic makeup hold promise for more effective healthcare.

58. Molecular Pharmacology: Understanding receptor-ligand interactions aids in the development of targeted drugs for specific diseases.

59. Biodiversity Conservation: Preserving habitat diversity is crucial to maintaining ecosystems and preventing species extinction.

60. Evolutionary Developmental Biology: Comparing embryonic development across species reveals shared genetic pathways and evolutionary constraints.

61. Plant Reproductive Strategies: Understanding the trade-offs between asexual and sexual reproduction in plants sheds light on their evolutionary success.

62. Parasite-Host Interactions: The coevolution of parasites and their hosts drives adaptations and counter-adaptations over time.

63. Genomic Diversity: Exploring genetic variations within populations helps uncover disease susceptibilities and evolutionary history.

64. Ecological Succession: Studying the process of ecosystem recovery after disturbances provides insights into resilience and stability.

65. Conservation Genetics: Genetic diversity assessment aids in formulating effective conservation strategies for endangered species.

66. Neuroplasticity and Learning: Investigating how the brain adapts through synaptic changes improves our understanding of memory and learning.

67. Synthetic Biology: Designing and engineering biological systems offers innovative solutions for medical, environmental, and industrial challenges.

68. Ethnobotany: Documenting the traditional uses of plants by indigenous communities informs both conservation and pharmaceutical research.

69. Ecological Niche Theory: Exploring how species adapt to specific ecological niches enhances our grasp of biodiversity patterns.

70. Ecosystem Services: Quantifying the benefits provided by ecosystems, like pollination and carbon sequestration, supports conservation efforts.

71. Fungal Biology: Investigating mycorrhizal relationships between fungi and plants illuminates nutrient exchange mechanisms.

72. Molecular Clock Hypothesis: Genetic mutations accumulate over time, providing a method to estimate evolutionary divergence dates.

73. Developmental Disorders: Unraveling the genetic and environmental factors contributing to developmental disorders informs therapeutic approaches.

74. Epigenetics and Disease: Epigenetic modifications contribute to the development of diseases like cancer, diabetes, and neurodegenerative disorders.

75. Animal Cognition: Studying cognitive abilities in animals unveils their problem-solving skills, social dynamics, and sensory perceptions.

76. Microbiota-Brain Axis: The gut-brain connection suggests a bidirectional communication pathway influencing mental health and behavior.

77. Neurological Disorders: Neurodegenerative diseases like Parkinson’s and Alzheimer’s have genetic and environmental components that drive their progression.

78. Plant Defense Mechanisms: Investigating how plants ward off pests and pathogens informs sustainable agricultural practices.

79. Conservation Genomics: Genetic data aids in identifying distinct populations and prioritizing conservation efforts for at-risk species.

80. Reproductive Strategies: Comparing reproductive methods in different species provides insights into evolutionary trade-offs and reproductive success.

81. Epigenetics in Aging: Exploring epigenetic changes in the aging process offers insights into longevity and age-related diseases.

82. Antimicrobial Resistance: Understanding the genetic mechanisms behind bacterial resistance to antibiotics informs strategies to combat the global health threat.

83. Plant-Animal Interactions: Investigating mutualistic relationships between plants and pollinators showcases the delicate balance of ecosystems.

84. Adaptations to Extreme Environments: Studying extremophiles reveals the remarkable ways organisms thrive in extreme conditions like deep-sea hydrothermal vents.

85. Genetic Disorders: Genetic mutations underlie numerous disorders like cystic fibrosis, sickle cell anemia, and muscular dystrophy.

86. Conservation Behavior: Analyzing the behavioral ecology of endangered species informs habitat preservation and restoration efforts.

87. Neuroplasticity in Rehabilitation: Harnessing the brain’s ability to rewire itself offers promising avenues for post-injury or post-stroke rehabilitation.

88. Disease Vectors: Understanding how mosquitoes transmit diseases like malaria and Zika virus is critical for disease prevention strategies.

89. Biochemical Pathways: Mapping metabolic pathways in cells provides insights into disease development and potential therapeutic targets.

90. Invasive Species Impact: Examining the effects of invasive species on native ecosystems guides management strategies to mitigate their impact.

91. Molecular Immunology: Studying the intricate immune response mechanisms aids in the development of vaccines and immunotherapies.

92. Plant-Microbe Symbiosis: Investigating how plants form partnerships with beneficial microbes enhances crop productivity and sustainability.

93. Cancer Immunotherapy: Harnessing the immune system to target and eliminate cancer cells offers new avenues for cancer treatment.

94. Evolution of Flight: Analyzing the adaptations leading to the development of flight in birds and insects sheds light on evolutionary innovation.

95. Genomic Diversity in Human Populations: Exploring genetic variations among different human populations informs ancestry, migration, and susceptibility to diseases.

96. Hormonal Regulation: Understanding the role of hormones in growth, reproduction, and homeostasis provides insights into physiological processes.

97. Conservation Genetics in Plant Conservation: Genetic diversity assessment helps guide efforts to conserve rare and endangered plant species.

98. Neuronal Communication: Investigating neurotransmitter systems and synaptic transmission enhances our comprehension of brain function.

99. Microbial Biogeography: Mapping the distribution of microorganisms across ecosystems aids in understanding their ecological roles and interactions.

100. Gene Therapy: Developing methods to replace or repair defective genes offers potential treatments for genetic disorders.

Scientific Hypothesis Statement Examples

This section offers diverse examples of scientific hypothesis statements that cover a range of biological topics. Each example briefly describes the subject matter and the potential implications of the hypothesis.

• Genetic Mutations and Disease: Certain genetic mutations lead to increased susceptibility to autoimmune disorders, providing insights into potential treatment strategies.
• Microplastics in Aquatic Ecosystems: Elevated microplastic levels disrupt aquatic food chains, affecting biodiversity and human health through bioaccumulation.
• Bacterial Quorum Sensing: Inhibition of quorum sensing in pathogenic bacteria demonstrates a potential avenue for novel antimicrobial therapies.
• Climate Change and Phenology: Rising temperatures alter flowering times in plants, impacting pollinator interactions and ecosystem dynamics.
• Neuroplasticity and Learning: The brain’s adaptability facilitates learning through synaptic modifications, elucidating educational strategies for improved cognition.
• CRISPR-Cas9 in Agriculture: CRISPR-engineered crops with enhanced pest resistance showcase a sustainable approach to improving agricultural productivity.
• Invasive Species Impact on Predators: The introduction of invasive prey disrupts predator-prey relationships, triggering cascading effects in terrestrial ecosystems.
• Microbial Contributions to Soil Health: Beneficial soil microbes enhance nutrient availability and plant growth, promoting sustainable agriculture practices.
• Marine Protected Areas: Examining the effectiveness of marine protected areas reveals their role in preserving biodiversity and restoring marine ecosystems.
• Epigenetic Regulation of Cancer: Epigenetic modifications play a pivotal role in cancer development, highlighting potential therapeutic targets for precision medicine.

Testable Hypothesis Statement Examples in Biology

Testability hypothesis is a critical aspect of a hypothesis. These examples are formulated in a way that allows them to be tested through experiments or observations. They focus on cause-and-effect relationships that can be verified or refuted.

• Impact of Light Intensity on Plant Growth: Increasing light intensity accelerates photosynthesis rates and enhances overall plant growth.
• Effect of Temperature on Enzyme Activity: Higher temperatures accelerate enzyme activity up to an optimal point, beyond which denaturation occurs.
• Microbial Diversity in Soil pH Gradients: Soil pH influences microbial composition, with acidic soils favoring certain bacterial taxa over others.
• Predation Impact on Prey Behavior: The presence of predators induces changes in prey behavior, resulting in altered foraging strategies and vigilance levels.
• Chemical Communication in Marine Organisms: Investigating chemical cues reveals the role of allelopathy in competition among marine organisms.
• Social Hierarchy in Animal Groups: Observing animal groups establishes a correlation between social rank and access to resources within the group.
• Effect of Habitat Fragmentation on Pollinator Diversity: Fragmented habitats reduce pollinator species richness, affecting plant reproductive success.
• Dietary Effects on Gut Microbiota Composition: Dietary shifts influence gut microbiota diversity and metabolic functions, impacting host health.
• Hybridization Impact on Plant Fitness: Hybrid plants exhibit varied fitness levels depending on the combination of parent species.
• Human Impact on Coral Bleaching: Analyzing coral reefs under different anthropogenic stresses identifies the main factors driving coral bleaching events.

Scientific Investigation Hypothesis Statement Examples in Biology

This section emphasizes hypotheses that are part of broader scientific investigations. They involve studying complex interactions or phenomena and often contribute to our understanding of larger biological systems.

• Genomic Variation in Human Disease Susceptibility: Genetic analysis identifies variations associated with increased risk of common diseases, aiding personalized medicine.
• Behavioral Responses to Temperature Shifts in Insects: Investigating insect responses to temperature fluctuations reveals adaptation strategies to climate change.
• Endocrine Disruptors and Amphibian Development: Experimental exposure to endocrine disruptors elucidates their role in amphibian developmental abnormalities.
• Microbial Succession in Decomposition: Tracking microbial communities during decomposition uncovers the succession patterns of different decomposer species.
• Gene Expression Patterns in Stress Response: Studying gene expression profiles unveils the molecular mechanisms underlying stress responses in plants.
• Effect of Urbanization on Bird Song Patterns: Urban noise pollution influences bird song frequency and complexity, impacting communication and mate attraction.
• Nutrient Availability and Algal Blooms: Investigating nutrient loading in aquatic systems sheds light on factors triggering harmful algal blooms.
• Host-Parasite Coevolution: Analyzing genetic changes in hosts and parasites over time uncovers coevolutionary arms races and adaptation.
• Ecosystem Productivity and Biodiversity: Linking ecosystem productivity to biodiversity patterns reveals the role of species interactions in ecosystem stability.
• Habitat Preference of Invasive Species: Studying the habitat selection of invasive species identifies factors promoting their establishment and spread.

Hypothesis Statement Examples in Biology Research

These examples are tailored for research hypothesis studies. They highlight hypotheses that drive focused research questions, often leading to specific experimental designs and data collection methods.

• Microbial Community Structure in Human Gut: Investigating microbial diversity and composition unveils the role of gut microbiota in human health.
• Plant-Pollinator Mutualisms: Hypothesizing reciprocal benefits in plant-pollinator interactions highlights the role of coevolution in shaping ecosystems.
• Chemical Defense Mechanisms in Insects: Predicting the correlation between insect feeding behavior and chemical defenses explores natural selection pressures.
• Evolutionary Significance of Mimicry: Examining mimicry in organisms demonstrates its adaptive value in predator-prey relationships and survival.
• Neurological Basis of Mate Choice: Proposing neural mechanisms underlying mate choice behaviors uncovers the role of sensory cues in reproductive success.
• Mycorrhizal Symbiosis Impact on Plant Growth: Investigating mycorrhizal colonization effects on plant biomass addresses nutrient exchange dynamics.
• Social Learning in Primates: Formulating a hypothesis on primate social learning explores the transmission of knowledge and cultural behaviors.
• Effect of Pollution on Fish Behavior: Anticipating altered behaviors due to pollution exposure highlights ecological consequences on aquatic ecosystems.
• Coevolution of Flowers and Pollinators: Hypothesizing mutual adaptations between flowers and pollinators reveals intricate ecological relationships.
• Genetic Basis of Disease Resistance in Plants: Identifying genetic markers associated with disease resistance enhances crop breeding programs.

Prediction Hypothesis Statement Examples in Biology

Predictive simple hypothesis involve making educated guesses about how variables might interact or behave under specific conditions. These examples showcase hypotheses that anticipate outcomes based on existing knowledge.

• Pesticide Impact on Insect Abundance: Predicting decreased insect populations due to pesticide application underscores ecological ramifications.
• Climate Change and Migratory Bird Patterns: Anticipating shifts in migratory routes of birds due to climate change informs conservation strategies.
• Ocean Acidification Effect on Coral Calcification: Predicting reduced coral calcification rates due to ocean acidification unveils threats to coral reefs.
• Disease Spread in Crowded Bird Roosts: Predicting accelerated disease transmission in densely populated bird roosts highlights disease ecology dynamics.
• Eutrophication Impact on Freshwater Biodiversity: Anticipating decreased freshwater biodiversity due to eutrophication emphasizes conservation efforts.
• Herbivore Impact on Plant Species Diversity: Predicting reduced plant diversity in areas with high herbivore pressure elucidates ecosystem dynamics.
• Predator-Prey Population Cycles: Predicting cyclical fluctuations in predator and prey populations showcases the role of trophic interactions.
• Climate Change and Plant Phenology: Anticipating earlier flowering times due to climate change demonstrates the influence of temperature on plant life cycles.
• Antibiotic Resistance in Bacterial Communities: Predicting increased antibiotic resistance due to overuse forewarns the need for responsible antibiotic use.
• Human Impact on Avian Nesting Success: Predicting decreased avian nesting success due to habitat fragmentation highlights conservation priorities.

How to Write a Biology Hypothesis – Step by Step Guide

A hypothesis in biology is a critical component of scientific research that proposes an explanation for a specific biological phenomenon. Writing a well-formulated hypothesis sets the foundation for conducting experiments, making observations, and drawing meaningful conclusions. Follow this step-by-step guide to create a strong biology hypothesis:

1. Identify the Phenomenon: Clearly define the biological phenomenon you intend to study. This could be a question, a pattern, an observation, or a problem in the field of biology.

2. Conduct Background Research: Before formulating a hypothesis, gather relevant information from scientific literature. Understand the existing knowledge about the topic to ensure your hypothesis builds upon previous research.

3. State the Independent and Dependent Variables: Identify the variables involved in the phenomenon. The independent variable is what you manipulate or change, while the dependent variable is what you measure as a result of the changes.

4. Formulate a Testable Question: Based on your background research, create a specific and testable question that addresses the relationship between the variables. This question will guide the formulation of your hypothesis.

5. Craft the Hypothesis: A hypothesis should be a clear and concise statement that predicts the outcome of your experiment or observation. It should propose a cause-and-effect relationship between the independent and dependent variables.

6. Use the “If-Then” Structure: Formulate your hypothesis using the “if-then” structure. The “if” part states the independent variable and the condition you’re manipulating, while the “then” part predicts the outcome for the dependent variable.

7. Make it Falsifiable: A good hypothesis should be testable and capable of being proven false. There should be a way to gather data that either supports or contradicts the hypothesis.

8. Be Specific and Precise: Avoid vague language and ensure that your hypothesis is specific and precise. Clearly define the variables and the expected relationship between them.

9. Revise and Refine: Once you’ve formulated your hypothesis, review it to ensure it accurately reflects your research question and variables. Revise as needed to make it more concise and focused.

10. Seek Feedback: Share your hypothesis with peers, mentors, or colleagues to get feedback. Constructive input can help you refine your hypothesis further.

Tips for Writing a Biology Hypothesis Statement

Writing a biology alternative hypothesis statement requires precision and clarity to ensure that your research is well-structured and testable. Here are some valuable tips to help you create effective and scientifically sound hypothesis statements:

1. Be Clear and Concise: Your hypothesis statement should convey your idea succinctly. Avoid unnecessary jargon or complex language that might confuse your audience.

2. Address Cause and Effect: A hypothesis suggests a cause-and-effect relationship between variables. Clearly state how changes in the independent variable are expected to affect the dependent variable.

3. Use Specific Language: Define your variables precisely. Use specific terms to describe the independent and dependent variables, as well as any conditions or measurements.

4. Follow the “If-Then” Structure: Use the classic “if-then” structure to frame your hypothesis. State the independent variable (if) and the expected outcome (then). This format clarifies the relationship you’re investigating.

5. Make it Testable: Your hypothesis must be capable of being tested through experimentation or observation. Ensure that there is a measurable and observable way to determine if it’s true or false.

6. Avoid Ambiguity: Eliminate vague terms that can be interpreted in multiple ways. Be precise in your language to avoid confusion.

7. Base it on Existing Knowledge: Ground your hypothesis in prior research or existing scientific theories. It should build upon established knowledge and contribute new insights.

8. Predict a Direction: Your hypothesis should predict a specific outcome. Whether you anticipate an increase, decrease, or a difference, your hypothesis should make a clear prediction.

9. Be Focused: Keep your hypothesis statement focused on one specific idea or relationship. Avoid trying to address too many variables or concepts in a single statement.

10. Consider Alternative Explanations: Acknowledge alternative explanations for your observations or outcomes. This demonstrates critical thinking and a thorough understanding of your field.

11. Avoid Value Judgments: Refrain from including value judgments or opinions in your hypothesis. Stick to objective and measurable factors.

12. Be Realistic: Ensure that your hypothesis is plausible and feasible. It should align with what is known about the topic and be achievable within the scope of your research.

13. Refine and Revise: Draft multiple versions of your hypothesis statement and refine them. Discuss and seek feedback from mentors, peers, or advisors to enhance its clarity and precision.

14. Align with Research Goals: Your hypothesis should align with the overall goals of your research project. Make sure it addresses the specific question or problem you’re investigating.

15. Be Open to Revision: As you conduct research and gather data, be open to revising your hypothesis if the evidence suggests a different outcome than initially predicted.

Remember, a well-crafted biology science hypothesis statement serves as the foundation of your research and guides your experimental design and data analysis. It’s essential to invest time and effort in formulating a clear, focused, and testable hypothesis that contributes to the advancement of scientific knowledge.

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Home > FACULTIES > Biology > BIOLOGY-ETD

Biology Theses and Dissertations

This collection contains theses and dissertations from the Department of Biology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

Theses/Dissertations from 2024 2024

Identification and characterization of isoflavone reductase family members in soybean , Negin Azizkhani

Ecological drivers of songbird stopover behaviour during autumn migration in eastern New Brunswick , Andrew T. Beauchamp

Understanding mechanisms underlying changes in parental care behaviour in response to perceived paternity in sunfish , Emma Churchman

Biosynthesis of a Novel O-methylhydroxy Isoflavone in Soybean: Expression Analysis and Identification of Isoflavone O-methyltransferases , Elizabeth Copley

Effects of evolved migration strategy, seasonal flexibility, and endurance flight on songbird mitochondrial bioenergetics , Soren Zachary Coulson

The Role of Mycorrhizal Associations in Modulating Poplar Growth, Phytohormone Responses, and Mortality under Elevated CO2 and Temperature Conditions , Joshua JR Frank-Webb

Characterization of brain metabolism in a mouse model of Alzheimer's Disease using MALDI-TOF imaging mass spectrometry , Sandra Grahovac-Nemeth

Determining the Effects of Mistranslating Transfer RNA Variants on Drosophila Melanogaster , Joshua R. Isaacson

Deciphering the Role of Cytochrome P450 Monooxygenases in Resistance to Phytophthora sojae in Soybean: Genomic Insight into Glyceollin Biosynthesis , Praveen khatri

Exploring the potential of the insect gut-brain axis to modulate the hygienic behaviour of Western honey bees (Apis mellifera) , Sophie M. Killam

A multilocus phylogeny of Hericium fungi in Canada and their production of Erinacine A , Julien Koga

Mercury Exposure, Fuel Stores and Torpor Use in Silver Haired Bats , Melina Kuerschner

The role of fruitless P3 and P4 transcripts in Drosophila melanogaster , Sara A. Kulinski

Spatially explicit assignment of harvested waterfowl using stable isotopes , Jackson W. Kusack

Potential for probiotics to mitigate environmental stress in Western honey bees , Andrew P. Pitek

The correspondence between genotype at bacterial and viral-facing Toll-like receptors and preen oil chemical composition in song sparrows , Justin To

Soybean Cytochrome P450s and The Making of Aliphatic Suberin Monomers , Lorena S. Yeung

Theses/Dissertations from 2023 2023

SUFU in SHH signalling mediated myogenesis , Suleyman Abdullah

Effect of rearing conditions on the allocation of larval and adult acquired essential and nonessential fatty acids to flight in two adult Lepidoptera: Danaus plexippus and Mythimna unipuncta , Libesha Anparasan

The effect of dietary thiaminase on cardiac function and morphology in lake trout (Salvelinus namaycush) , Peter Baker

The introduction of nursery seedlings and their fungi to a spruce-fir forest in Newfoundland , Alicia G. Banwell

Evaluating Phosphorylation as a Potential Regulator of ADT5 in Arabidopsis thaliana , Eileen Barac

Elucidating the neural circuitry underlying social spacing in Drosophila melanogaster through the lens of neuroligin 3 , Abigail T. Bechard

Development of reverse genetics tools in the two-spotted spider mite Tetranychus urticae , Nivitha Bhaskar

Post-breeding survival of adult and hatch-year Bank Swallows (Riparia riparia) in the Great Lakes region: a radio telemetry study , Christian M.M Buchanan-Fraser

Effects of 11-KT and Prolactin on Gene Expression, Parental Care Behaviour and Immune Response in Male Bluegill Sunfish. , Adriano A P da Cunha

Differential Migration Timing and the Form and Function of Avian Wings , Jessica E. Deakin

Unraveling The Evolution And Diversity Of Giant Plastid Genomes In Chlamydomonadalean Green Algae , Hager Gaouda

Elucidating the Relationships Between Spider Size, Joint Stiffness, and the Mechanical Frequency Response of the Body , Reese L. Gartly

The effects of elevated carbon dioxide and warming on photosynthesis and growth in five boreal tree species , Julia M. Hammer

Molecular Characterization of Osmotin and Four Plasmodesmata Callose Binding Protein Homologs from Arabidopsis in Turnip Mosaic Virus Infection , Rongrong He

The effects of warming on floral traits , Kiana J. Lee Ms.

The Adaptor Protein p66Shc Governs Central Nervous System Cell Metabolism and Resistance to Aβ Toxicity , Asad Lone

The detectability of Atlantic salmon (Salmo salar) microsatellite and mitochondrial environmental DNA , Simone N. Miklosi

Changes in peatland soil fauna biomass alter food web structure and function under warming and hydrological changes , Trevor L. Pettit

Mouse Genotyping Array-Based Analysis of Variation at Single Nucleotide Polymorphic Loci in the Context of Macro- and Micro-environments , Freda Qi

Investigating the Soil Mycobiome of American Ginseng , Rachel Amelia Rajsp

Age and Sex Differences in Stopover Behaviours and Flight Performance in Black-throated Blue Warblers , Patricia Rokitnicki

Freezing tolerance of herbaceous legumes within southwestern Ontario: evidence of disproportionate freezing sensitivity , Samuel L. Rycroft

Short-term versus long-term effects of nitrogen addition and warming on ecosystem N dynamics in a grass-dominated temperate old field , Benjamin F. A. Souriol

Characterization of Etoxazole Resistance in Tetranychus urticae Populations Collected from Commercial Greenhouses & Fields in Ontario , Jeremy Spenler

Molecular identification and characterization of Heat shock protein 70 family proteins essential for Turnip mosaic virus infection in Arabidopsis thaliana , Ziwei Tang

Role and regulation of galectin-12 in the context of cellular differentiation , Rada Tazhitdinova

Random Mating in the Face of Balancing Selection at the Major Histocompatibility Complex Class I in Song Sparrows (Melospiza melodia) , Scout R.L Thompson

Investigating soil microbiome changes during Panax quinquefolius cultivation in new gardens , Pok Man Paul Wan

Recovery from social isolation in Drosophila: The role of dopamine and the autism-related gene nlg3. , Ryley T. Yost

Theses/Dissertations from 2022 2022

Effects of the Brain Nonapeptides Arginine-Vasotocin and Isotocin on Shoaling Behaviour in the Guppy (Poecilia reticulata) , Babak Ataei Mehr

Effects of methylmercury and unpredictable food stress exposure on songbirds’ physiology and seasonal transition , Claire L.J. Bottini

Gene Regulatory Context of Honey Bee Worker Sterility , Rahul Choorakkat Unnikrishnan

The Sequence-Function Relationship of Arabidopsis AROGENATE DEHYDRATASES , Emily J. Clayton

Characterization of SPL4's role in drought stress and trichome development in alfalfa , Matei A. Dan-Dobre

Cadmium Uptake in Plants as Influenced by Selenium Uptake and Sulphate Availability , Marnie J. Demand

Nitrogen transfer from cover crops to the subsequent grain crop and the influence of variability in winter conditions , Spencer Heuchan

Effects of Experimental Malaria Infection On Migration of Yellow-rumped Warblers (Setophaga coronata) , Rebecca J. Howe

Understanding the molecular mechanism of postharvest seed coat darkening in pinto beans , Nishat Shayala Islam

Characterization of galectin-16 expression and function in placental cells , Jennifer Kaminker

Using conservation genetics to inform reintroduction of the endangered Mottled Duskywing (Erynnis martialis) , Shayla Kroeze

Mechanisms of Diapause and Cold Tolerance in the Colorado Potato Beetle , Jacqueline E. Lebenzon

Effects of spatial and temporal heterogeneity on the genetic diversity of the alpine butterfly Parnassius smintheus , Mel Lucas

The Biosynthesis of Non-protein Sulfur Amino Acid in Developing Seeds of Common Bean , Zixuan Lu

Additional Sulfur Does Not Alleviate Cadmium Toxicity In Soybean , Spencer Matt

From Individuals To Communities: The Effect Of Climate Change On Ectothermic Predators , Matthew Lawrence Meehan

Temperature-Dependent Developmental Plasticity in the Cardiorespiratory System of Atlantic Salmon , Carlie A. Muir

Characterization of the Role of miR156-SPL12 Regulatory Module in Root Architecture and Stress Response in Medicago sativa (alfalfa) , Vida Nasrollahi

The impact of long-term artificial removal experiment and natural local extinctions on the genetics of an alpine butterfly , Keon Young Park

Role of HXXXD-motif acyltransferases in suberin biosynthesis , Yudelkis Indira Queralta Castillo

Spatiotemporal characterization of the prr12 paralogues in zebrafish , Renee Jeannine Resendes

Manipulating the root mycobiome to improve plant performance and reduce pathogen pressure in corn (Zea mays) , Noor F. Saeed Cheema

The role of galectins in differentiation of acute myeloid leukemia cells , Jolaine Smith

Regulation of Hedgehog and Wnt Signaling in Neural Differentiation of P19 Embryonal Carcinoma Cells , Danielle Margaret Spice

Biochemistry of trehalose accumulation in the spring field cricket, Gryllus veletis , Alyssa R. Stephens

Investigation of HD2 family histone deacetylases relationship in drought stress response and root growth in Arabidopsis thaliana , Muhammad Sufyan Tahir

Western diet-like culture conditions and oxidative stress on a cell model of non-alcoholic fatty liver disease , Celina M. Valvano

Root-Inhabiting and Rhizosphere Mycobiomes and Crop Yield of Corn and Wheat , Marianna E. Wallace

MT1-MMP enhances cell survival and proliferation via roles unrelated to metabolic transcript levels in MCF7 breast cancer cells , Rachel A. Wise

Using Stable Isotope Techniques To Complement Existing Northern Pintail Management. , Dariusz Wojtaszek

Theses/Dissertations from 2021 2021

The Effects of Silver Nanoparticles on Soybean (Glycine max) Growth and Nodulation , Paul J. Boersma

Response of the Soil Bacterial Community, Resistome, and Mobilome to a Decade of Macrolide Antibiotic Contamination , Liam Paul Brown

Screens for Phenotypic Non-Specificity of Transcription Factor Function in Drosophila melanogaster , Sheng Cheng

A genetic perspective on social insect castes: A synthetic review and empirical study , Anna M. Chernyshova

Investigating social dynamics using automated radiotracking of winter flocks of Black-capped chickadees (Poecile atricapillus) , Christopher J. Course

Long-term vs. Short-term Plant Responses to Warming and Nitrogen Addition in a Temperate Old Field , Breanna Craig

Diversity and drivers of oribatid mites (Acari: Oribatida) in boreal peatlands , Carlos Rafael de Araujo Barreto

Effects of Gene-Environment Interactions on the Evolution of Social Behaviours , Vonica J. Flear

Fear of the Human "Super-Predator" In African Mammals , Nikita R. Frizzelle

Metabolic regulation during extraembryonic endoderm differentiation , Mohamed Gatie

Hibernation is super complex: dynamics of electron transport system supercomplexes , Amalie J. Hutchinson

The Analysis of Ginsenosides in Ginseng Garden Soil , Karina Marie Kaberi

Dynamics of the Soil Microbiome in Ginseng Gardens , Megan E. Lambert

Metschnikowia mitochondria , Dong Kyung Lee

Food Caching Decisions in Canada Jays (Perisoreus canadensis) , Robert J. Martin

Insights into O-GlcNAc-mediated regulation of galectin expression and secretion in promyelocytic HL-60 cells , Adam J. McTague

Developing a toolbox to engineer quantitative trait variation in legume species using CRISPR/Cas technologies. , Petar Miletic

Kindlin-1 is involved in spreading, migration, and protein regulation in epidermal SCC-13 cells , Naomi Mishan

Evaluation of two mouse models of high genetic variation for suitability to test a heterozygote instability hypothesis , Hailie Pavanel

Evaluation of the Bioactive Properties of Peptides Derived From the Common Bean (Phaseolus vulgaris L.) , Zhujun Qiu

Mitigation of Replant Disease using Solarization in American Ginseng (Panex quinquefolius) , Andrew G. Rabas

Functional Characterization of Arogenate Dehydratase Isoforms in Soybean , Ramtin Sirjani

Short-term vs. Long-term Warming and Nitrogen Treatment Effects on Soil Carbon and Microbial Activity in a Temperate Old Field , Erica Stroud

Production of self-assembling protein nanocages and virus-like particles displaying porcine reproductive and respiratory syndrome virus epitopes in Nicotiana benthamiana , Jordan T. VanderBurgt

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Research in the Biological and Life Sciences: A Guide for Cornell Researchers: Literature Reviews

• Books and Dissertations
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• Measuring your research impact
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What is a Literature Review?

A literature review is a body of text that aims to review the critical points of current knowledge on a particular topic. Most often associated with science-oriented literature, such as a thesis, the literature review usually proceeds a research proposal, methodology and results section. Its ultimate goals is to bring the reader up to date with current literature on a topic and forms that basis for another goal, such as the justification for future research in the area. (retrieved from  http://en.wikipedia.org/wiki/Literature_review )

Writing a Literature Review

The literature review is the section of your paper in which you cite and briefly review the related research studies that have been conducted. In this space, you will describe the foundation on which  your  research will be/is built. You will:

• discuss the work of others
• evaluate their methods and findings
• identify any gaps in their research
• state how  your  research is different

The literature review should be selective and should group the cited studies in some logical fashion.

If you need some additional assistance writing your literature review, the Knight Institute for Writing in the Disciplines offers a  Graduate Writing Service .

Demystifying the Literature Review

For more information, visit our guide devoted to " Demystifying the Literature Review " which includes:

• guide to conducting a literature review,
• a recorded 1.5 hour workshop covering the steps of a literature review, a checklist for drafting your topic and search terms, citation management software for organizing your results, and database searching.

Online Resources

• A Guide to Library Research at Cornell University
• Literature Reviews: An Overview for Graduate Students North Carolina State University 
• The Literature Review: A Few Tips on Conducting Written by Dena Taylor, Director, Health Sciences Writing Centre, and Margaret Procter, Coordinator, Writing Support, University of Toronto
• How to Write a Literature Review University Library, University of California, Santa Cruz
• Review of Literature The Writing Center, University of Wisconsin-Madison

Print Resources

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• Last Updated: Oct 25, 2023 11:28 AM
• URL: https://guides.library.cornell.edu/bio

Excellent opening paragraph stating why is the research important and leading to the research goals

Clear and concise presentation of research aims \(questions\)

Research plan is well \ detailed starting from third paragraph.

Pronoun problem: who is the "w\ e"? Earlier, "I" is very clear, but this "we" lacks a clear antecedent.

Writing tip: good use of "signa\ l" words \("first," "second"\) to organize information and highlight key points.

Contributors: P. Pazos, Searle Center for Teaching Excellence and P. Hirsch, The Writing Program, [email protected]

Posted: 2008

TITLE: The Mitochondrial Stress Response and the Communication of Stress Responses Between Subcellular Compart\ ments

Compelling presentation of preparation from courses and prior lab experience.

Very detailed presentation of techni\ ques learned that are relevant to the project

Writing tip: "data" is a p\ lural word. Say, "The data suggest. . . " and "they [meaning the data] indicate."

Overall comments:

Good quality proposal overall. The author clearly explains the aims a\ nd methods to carry out those aims.

Research question: Analysis of mitochondria's unfolding protein response and its crosstalk with other folding envir\ onments in the cell.

Compelling presentation of prior experience in courses and labs. Could include specific techniques learned.

Good use of citations and references

Suggestions:

Should add headings to make it more readable and add some structure.