| | | |
databases have two features to help you find search words as well as topics and sub-topics. Use the "subject guide search" feature in databases to help you find good search terms. . Use the "topic finder" to help you find good topics and sub-topics | | |
The NSDL is an open access library of digital content relevant to all aspects of hard and applied sciences. | |
Writing the Essay
An essay in the sciences requires is more than just generating and presenting data. Analysis of the data is also essential. The main body of the essay should consist of an argument or evaluation based on the data or information presented . You can gather your own data through a variety of methods, or rely on secondary data. You should use graphs, tables, or diagrams to point out the significance of your findings.
You should ensure that the main body of the essay is well structured and has an obvious logical progression. You can use numbered and headed paragraphs to impose a clear structure. Your evaluation should show that you understand the the data they have collected and its significance to the world.
In your analysis, you should also describe and explain the limitations imposed on the research by factors such as
- the suitability and reliability of the sources accessed
- accuracy and precision of measuring equipment
- sample size
- validity and reliability of statistics
Students should also consider biological limitations such as:
- those arising from the problem of repeatability and control when using living material
- the difficulties of generalizing from research based on a single type of organism or environment.
Exceptions for Safety and Academic Honesty
Safety and Ethics in Choosing a Topic
In all cases where human subjects are used as the basis for an investigation, clear evidence of informed consent must be provided in accordance with the IB guidelines.
Some topics may be inadmissible because their means of investigation are unethical. For example, investigations that:
- are based on experiments likely to inflict pain on, or cause stress to, living organisms
- are likely to have a harmful effect on health, eg culturing micro-organisms at or near body temperature (37°C)
- involve access to, or publication of, confidential medical information.
Some topics may be unsuitable because of safety issues. Adequate safety apparatus and qualified supervision is required for experiments involving dangerous substances such as:
- toxic or dangerous chemicals
- carcinogenic substances
- radioactive materials.
Other topics may be unsuitable because the outcome is already well known and documented in standard textbooks.
Assessed Student Work
- The Antimicrobial Effects of Metals Copper, Barium and Silver on the Growth of Bacteria
- Effects of different calcium salts in growth solutions on the growth of the stems of basil (Ocimum basilicum) plants grown hydroponically
- << Previous: Language and Literature
- Next: Sciences: Sports, Exercise, and Health Sciences >>
- Last Updated: Apr 18, 2024 6:27 AM
- URL: https://k497.libguides.com/extendedessay
2016-2025 IB Extended Essay: Sample IB EE's
- Workshop 1: Getting started
- Workshop 2: EE Options
- Workshop 3: Selecting a topic
- Workshop 4:Research Questions
- Workshop 5: Supervisors and Reflections
- Finding Books & Ebooks
- Primary Sources
- Citation Guide
- Subject guidance
- Sample IB EE's
- Biology (2018 new rubric)
- Biology Light Intensity
- Does Age Have an Effect on Short-term Memory of 6 to 18 Year Old Students?
Chemistry:
- Chemistry 1
- What are the Alternative Fuels for the Depleting Fossil Fuels and which is the Best Fuel in Accordance with the Energy Output?
- A Copper Ions
- Chemistry 3
Design Technology
- Does Hull Trim and Balance Affect the Speed of a Boat?
Individuals & Society:
- Market Form of the Retail Petroleum Supply Industry in Parklands
- Economics 1
- Economics 2
- Economics 3
I have an exemplar but the file is too big to upload. If you are interested in this topic I can share the essay with you.
- Geography 2
- History EE (2018 new rubric)
- To What Extent was the Establishment of the State of Israel in Palestine in 1948, Influenced by Theodor Herzl?
Information Technology in a Global Society
- Philosophy 1
- Philosophy 2
- Philosophy 3
- Philosophy 4
- Psychology EE (2018 new rubric)
- Applied Behavior Analysis and Early Intervention: The Extent of Recovery from Autism
- Psychology 1
- Psychology 2
- Psychology 3
Social & Cultural Anthropology
- Social & Cultural Anthropology 1
- Social & Cultural Anthropology 2
World Religions
- To What Extent do the Core Scriptural Teachings of Sikhism Permit them to Marry Outside of the Religion?
- World Religions 1
- World Religions 2
Language Acquisition:
- French: Les Liaisons Dangereuses
Literature & Language
- Journeys in the Inferno and The Wonderful Wizard of Oz
- Toni Morrison
Math:
- Cryptography and Rubik's Cube: An Investigative Analysis
- Pascal's Triangle
Visual Arts:
- How Does the work of Yinka Shonibare Illustrate the Changing Role of African Art in a Global Society?
- Ballet's Accessibility and Costumes Affecting Society's View of the Art Form
- Visual Arts 1
- Visual Arts 4
Interdisciplinary Essays:
Environmental Systems & Societies
- ESS Extended Essay (2018 new rubric)
World Studies
- World Studies EE History, Economics, & Politics (2018 new rubric)
- Does the Production of Dairy and Meat from Dairy Cows in the United States affect the Environment and Well Being of Animals and Humans?
- << Previous: Subject guidance
- Last Updated: Aug 19, 2024 10:10 AM
- URL: https://lewishs-fcps.libguides.com/IBExtendedEssay
EE Examples
Elevate your Extended Essay game for free! Get access to our unbeatable collection of Free EE Examples and score big on your IB exams.
Sell Your EE For $10 a pop!
Happy to give you $10 for every EE so we can give it away for free!
Top IA examples. Learn and excel.
Outstanding EE examples. Draft with confidence.
High-scoring IOs. Enhance your performance.
Exemplary TOK essays. Master your writing.
Top TOK exhibitions. Impress in assessments.
How Can The Exit Velocity Vector Of A Spacecraft Performing A Hyperbolic Flybymanoeuvre Be Calculated?
Explore How To Calculate The Exit Velocity Vector Of A Spacecraft In A Hyperbolic Flyby Maneuver. Discover Key Mathematical Insights In This Sample IB EE.
How Has The Standard Of Maternal-perinatal And Under 5 Healthcare In The Public Healthcare Sector Of Kenya Been Influenced By The Policies Being Implemented By The Kenyan Government
Explore How Kenyan Government Policies Influence Maternal-Perinatal And Under 5 Healthcare Standards In Kenya's Public Healthcare Sector. Learn About Key Impacts
To What Extent Does Lack Of Support Influence The Development Of Depressive Symptoms In Transgender People Among Other Sociocultural Factors?
Explore the impact of support on transgender mental health in this insightful IB Psychology HL Extended Essay. Discover sociocultural influences and more.
¿En Qué Medida Fueron Efectivos Los Mecanismos De Control De Parte Del Nazismo Sobre La Pintura A Lo Largo Del Gobierno De Hitler (1933 - 1945) En Alemania?
Uncover The Effectiveness Of Nazi Control Over Art In Hitler's Germany Through This Sample IB History Core EE. Delve Into The Period From 1933 To 1945.
What Are The Most Significant Geographical Factors Affecting The Price Of Public Housing In Singapore?
Discover How Geographical Factors Influence Public Housing Prices In Singapore Through Our Expert IB Geography HL Extended Essay.
¿De Qué Manera Las Decisiones Estilísticas En La Invención De Morel Influyen En El Paso De Lo Inverosímil A La Verosimilitud Neofantástica?
Discover How Stylistic Choices In "La Invención De Morel" Transform The Unbelievable Into Neo-Fantastic Realism. A Deep Dive Into Spanish HL IB Sample IA.
¿De Qué Manera Lo Absurdo Y El Sinsentido Generan Un Dualismo Entre El Ser Y El Parecer En Los Cuentos "El Otro Yo”, “el Altillo” Y “acaso Irreparable” De “la Muerte Y Otras Sorpresas” Título Del Libro De Cuentos De Mario Benedetti?
Explore The Dualism Between Being And Appearing In Mario Benedetti's "La Muerte Y Otras Sorpresas" Stories Through Absurdity And Nonsense. Dive Into This Sample EE.
The Significance Of Apple's Unique Selling Proposition (USP) In Establishing Its Dominance Within The Consumer Electronics Industry.
Discover How Apple's Unique Selling Proposition Ensured Its Leadership In Consumer Electronics. Explore This Insightful IB Business Management HL Extended Essay.
How Was Language Used By The British Press To Portray The 2015 European Migration Crisis?
Discover How The British Press Used Language To Portray The 2015 European Migration Crisis In This Sample IB English Language And Literature HL Extended Essay.
The Effectiveness Of Hong Kong's 2022 E-Cigarette Ban
Discover How Hong Kong's 2022 E-Cigarette Ban Impacts Public Health And Economy In This Insightful IB Economics HL Extended Essay Sample. Dive In For Key Insights!
To What Extent Did The Nazi Military’s Superior Strategy Secure A German Victory During The Battle Of France In 1940?
Discover How The Nazi Military's Superior Strategy Secured Victory During The 1940 Battle Of France In This Insightful IB History SL Extended Essay.
The Impact Of The New Railway Catering Policy On Consumer Consumption In The Mumbai Railway Food Catering System In Maharashtra India?
Explore How The New Railway Catering Policy Impacts Consumer Consumption In Mumbai's Railway Food System. Discover Key Insights In This Sample IB Economics SL EE.
How Game Theory The Use Of Vectors & Algorithms Contribute To The Effective Operation Of Today’s Chess Engines?
Discover How Game Theory, Vectors, And Algorithms Revolutionize Modern Chess Engines For Unmatched Strategy And Precision. Dive Into The Mechanics Of Chess Mastery!
How Does American Psycho Depict How Our Environment Shapes Toxic Masculinity Through The Characterization Of Patrick Bateman?
Discover How American Psycho Depicts The Influence Of Environment On Toxic Masculinity Through Patrick Bateman's Characterization In This Sample IB English A LAL SL EE.
The Trope Of Inner Journey In Salvaging The Dichotomized Entities
Unlock The Secrets Of Inner Journeys In IB English: A Sample EE Analyzing Dichotomized Entities. Explore Expert Insights On Salvaging Complex Themes.
An Analysis Of Order And Authority In The Knight’s Tale
Discover Insights On Order And Authority In The Knight's Tale With This Comprehensive Sample EE For IB English A Literature SL. Click To Explore Now!
How Authors Prompt Readers To Empathise With Villains In Literature
Explore How Authors Prompt Readers To Empathize With Villains In Literature Through This Sample IB English A LAL Core EE. Unlock The Secrets Behind Complex Characters
A Comparative Study Of The Impacts Of The Covid-19 Pandemic On The Hospitality Industry In Switzerland & Madagascar
Discover A Comparative Study Of The Impacts Of The Covid-19 Pandemic On The Hospitality Industry In Switzerland And Madagascar. Insightful And Comprehensive Analysis Awaits.
How Does Gurnah Use Characterization & The Motif Of Dislocation To Reveal Social Struggles In Colonial East Africa In Paradise?
Meta Description: Unlock The Secrets Of Social Struggles In Colonial East Africa Through Gurnah's Masterful Use Of Characterization And Motifs In Our Sample EE.
How Can The Application Of Daniel Pink's Motivation Theory Help Google Boost Its Employee Engagement In A Post - Covid Era?
Discover How Daniel Pink's Motivation Theory Can Boost Google's Employee Engagement In A Post-Covid Era. Explore This Sample IB Business Management SL EE Today!
South Africa’s Alcohol Ban During The Covid-19 Pandemic
Discover The Impact Of South Africa’s Alcohol Ban During The COVID-19 Pandemic In This Insightful IB Economics SL Extended Essay Sample. Learn More About Economic Effects.
How Does Activation Voltage Depend On The Wavelength Of LED Radiation Measured In The Range 400 To 800 nm And How Can This Information Be Used To Measure Planck’s Constant?
Discover How Activation Voltage Depends On LED Wavelengths (400-800 nm) And Learn How To Measure Planck’s Constant In This Sample IB Physics SL Extended Essay.
A Socialist Spectacle An Investigation Into Salvador Allende’s Effectiveness As President
Discover A Socialist Spectacle: An Investigation Into Salvador Allende’s Effectiveness As President In This Sample IB History SL Extended Essay.
To What Extent Is It Fair To Say That The Warsaw Ghetto Uprising Of 1943 Was Doomed To Fail
Discover How The 1943 Warsaw Ghetto Uprising Challenged Fate And Made History. An In-Depth Sample IB History SL Extended Essay Analysis Awaits. Explore Now!
To What Extent Did The Influence Of The British Raj Prove To Be Beneficial For Karachi?
Discover How The British Raj's Influence Shaped Karachi's History In This Compelling Sample IB History SL Extended Essay. Dive Deep Into The Benefits And Impacts Today.
To What Extent Did Ideological Differences Instigate The Deterioration Of Sino-Soviet Relations Thereby Leading To The Sino-Soviet Split Of 1963
Discover How Ideological Differences Fueled The Sino-Soviet Split Of 1963 In This Sample IB History SL Extended Essay. Explore Key Events And Influential Factors.
To What Extent Can Anne Boleyn Be Regarded As The Key Figure In Henry VIII’s Reformation Of The Church In England?
Discover How Anne Boleyn Shaped Henry VIII’s Church Reformation. Explore Her Influence And Role In England’s Historic Religious Transformation. Perfect For IB History SL.
A Reflection Of The Cold War Or A Soviet Attempt To Meddle In A Sovereign Nation’s Affairs?
Explore The Cold War's Impact On Sovereign Nations Through This Sample IB History EE – A Compelling Analysis Of Soviet Influence And Political Intrigue.
The Aims, Process And Effects Of Collectivisation Of Agriculture, 1940-1949
Unlock The Secrets Of Agricultural Collectivisation: Dive Into The Aims, Process, And Effects From 1940-1949 In This Comprehensive IB History SL Sample EE.
To What Extent Was The Nationalists’ Victory In The Spanish Civil War The Result Of Foreign Assistance From Adolf Hitler And Benito Mussolini?
Unlock The Secrets Of The Spanish Civil War: Discover How Foreign Aid Influenced The Nationalists' Victory In This Sample IB History SL Extended Essay.
Was The Hitler Youth Successful In Providing Supporters For The National Socialists
Discover How The Hitler Youth Shaped Future National Socialist Supporters In This Comprehensive IB History SL Extended Essay Sample.
To What Extent Did King George VI & Queen Elizabeth’s Policy Strengthen British Morale During The Second World War?
Discover How King George VI & Queen Elizabeth’s Policy Boosted British Morale During WWII In This Sample EE For IB History SL.
For What Reasons Was Margaret Thatcher Able To Win The 1983 General Election
Explore Why Margaret Thatcher Won The 1983 General Election Through This Sample IB History SL Extended Essay. Discover Key Factors And Historical Insights.
An Evaluation Of The Causes Of The Barcelona May Days 1937 According To Contemporary Commentators & Later Historians
Explore The Causes Of The Barcelona May Days 1937 Through The Eyes Of Contemporary Commentators And Later Historians. Discover Unique Insights And Historical Perspectives.
An Assessment Of The Apartheid Years, Leading To The Insurrections Of 1983- 1986, And Second State Of Emergency On June 12, 1986
Explore An In-Depth Assessment Of Apartheid Years, Leading To The Insurrections Of 1983-1986, And The Second State Of Emergency On June 12, 1986
An Investigation Into Salvador Allende’s Effectiveness As President
Discover An Insightful Sample EE On IB History SL: An Investigation Into Salvador Allende’s Effectiveness As President. Explore Detailed Analysis And Critical Evaluations.
To What Extent Is There A Correlation Between The Number Of Employees And The Marginal Profit, The Number Of Employees And The Total Profit Over The Period From The Year 2010 To 2019, Determined Using Differentiation, Integration Of Logarithmic, Trigonometric, Inverse Trigonometric, Exponential, Polynomial Functions And Regression Analysis
Discover The Role Of Financial Mathematics In Correlating Employee Count, Marginal Profit, And Total Profit With This Comprehensive IB Mathematics AI SL Sample EE.
Time Frame Analysis Of Stock Prices At Amazon Using Financial Mathematics
Explore The Time Frame Analysis Of Amazon Stock Prices Using Financial Mathematics In This Sample IB Mathematics AI SL Extended Essay. Unlock Insights Today.
To What Extent Mathematical Analysis Of Variation Of Stock Prices In The Time Domain Can Be Used To Predict The Ideal Business Transactions In Stock Market For Amazon Inc. Using Differentiation, First Order And Second Derivative & Calculus?
Unlock The Secrets Of Financial Mathematics: Discover A Sample IB Math EE On Amazon Stock Price Time Frame Analysis. Perfect For IB Math AA SL Students Seeking Insights.
To What Extent Is There A Correlation Between The Number Of Employees & The Marginal Profit, The Number Of Employees & The Total Profit Over The Period From The Year 2010 To 2019, Determined Using Differentiation, Integration Of Logarithmic, Trigonometric, Inverse Trigonometric, Exponential, Polynomial Functions & Regression Analysis?
Explore How Financial Mathematics Uncovers The Correlation Between Employee Count, Marginal Profit, And Total Profit In This Sample IB Math AA SL Extended Essay
How Does The Magnitude Of Critical Micellization Concentration(CMC) Of Anionic Detergent, (Sodium Dodecyl Sulfate ) Depends On Temperature, Determined Using Conductometric Analysis?
Discover How Temperature Affects Anionic Detergent CMC Using Conductometric Analysis in This Sample IB Chemistry SL Extended Essay.
Is There Any Correlation Between The Freezing Point Of A Mixture Of Naphthalene And 4-nitrophenol And The Composition Of The Mixture (In Terms Of Mole-fraction), Determined Using Temperature Versus Composition Diagram?
Discover The Impact Of Mixture Composition On Freezing Point In This Sample IB Chemistry SL EE. Explore In-Depth Analysis And Insights To Ace Your Chemistry Extended Essay.
How Does The Magnitude Of Upper Critical Solution Temperature (Ucst) Of Phenol(Hydroxy Benzene)-aqueous Nacl System Depend On The Molar Concentration (Moldm -3 ) Of The Aqueous Solution Of Nacl Added To It, Determined Using Mutual Solubility Curve?
Discover How The UCST Of The Phenol-NaCl System Varies With Molar Concentration Through Mutual Solubility Curves In This Sample IB Chemistry SL EE.
To What Extent Has The Vape Ban Been Effective In Reducing The Welfare Costs Of Tobacco Consumption In Bangalore?
Discover How Bangalore's Vape Ban Impacts Tobacco Consumption Costs. Dive Into This IB Economics SL Sample EE To Explore Detailed Insights And Welfare Analysis.
To What Extent Do Various Economic Forces Contribute To The Optimum Allocation Of Resources In The Passenger Car Market Of Bangalore, After 2018?
Discover How Economic Forces Shape The Allocative Efficiency Of Bangalore's Passenger Car Market. Explore Key Insights In This Sample EE For IB Economics SL.
To What Extent Has The Procurement Of Cotton From The Cotton Farmers In Maharashtra, India By The Cotton Corporation Of India (Cci) Been Impacted By The Global Pandemic Of Covid-19 And Subsequent Lockdown?
Discover How The Global Pandemic Impacted Cotton Procurement By The Cotton Corporation Of India In Maharashtra, India – An In-Depth IB Economics SL EE Analysis.
How Does The Antimicrobial Effect Of Neutral Alcoholic Extract Of Ocimum Tenuiflorum (Tulsi Leaves), On The Growth Of Saccharomyces Cerevisiae (Yeast), Measured In Terms Of Percentage Inhibition Of Growth Of Yeast Depends On The Percentage Strength Of The Tulsi Extract Used – 10%, 20%, 30%, 40% And 50%, Determined Spectrophotometrically?
Explore How Tulsi Inhibits Yeast Growth: A Detailed IB Biology Sample EE. Discover Antimicrobial Effects And Gain Insight For Your Own Research!
How Does The Rate Of Alcoholic Fermentation (In Cm 3 Min -1 ), Measured In Terms Of Volume Of Co 2 Produced Depends On The Type Of The Sugar Unit-sucrose, Glucose, Fructose And Starch Used As Substrate, Determined Using Gas Collection Method?
Unlock The Secrets Of Alcoholic Fermentation: Discover How Substrate Nature Influences Fermentation Rates In This Comprehensive IB Biology SL Sample Extended Essay.
How Does The Terminal Velocity In Cm S -1 Of An Object Falling Through A Liquid Depends On The Density Of The Liquid It Is Falling Through, Determined Using Velocity-time Graph?
Discover How Fluid Density & Object Shape Influence Terminal Velocity In This IB Physics SL Sample EE. Boost Your Understanding With This Comprehensive Guide.
To What Extent Has The Acquisition Of Essar Oil By Rosneft Helped Them Attain Profitability?
Unlock The Secrets Of Profitability: A Deep Dive Into Rosneft's Strategic Acquisition Of Essar Oil For IB Business Management SL.
How Does The Interference Fringe Width (Distance Between Two Maxima i.e. Two Bright Spots) Depend On The Diameter Of The Slits (Behaving As Source), Refractive Index Of Medium Present Between The Source Of The Light (Double Slit) & The Screen?
Discover How Interference Fringe Width Relates To Slit Diameter And Medium Refractive Index In This Sample IB Physics SL Extended Essay. Explore Key Insights And Analysis.
ToK Exhibition Objects Generator
Generating ToK exhibition objects was hard. QBIX AI makes it easy.
100 IB Extended Essay Topic Ideas!
One of the biggest keys to the Extended Essay is choosing which subject you want to write your work in and developing that crucial research question. Read on to find inspiration for topics across a wide range of subjects.
Extended Essay: The Love/Hate aspect of the IB
One of the biggest keys to the Extended Essay is choosing which subject you want to write your work in and developing that crucial research question. Annoyingly, coming up with that idea and research question can be the toughest part of the entire process. Writing 4,000 words about something you are interested in is a big ask and it often feels impossible to narrow down your thoughts. To make everything super clear, here are 100 Extended Essay Topics for you to draw inspiration from! Use these as a springboard to create your own research question !
Get Support from A Top Tutor Today
At Lanterna we have over 300 tutors who smashed their Extended Essay. They know exactly how to get an A in your EE and can give you tips and tricks on how you can do the same. What are you waiting for? Get your own tutor today !
How to Begin Your IB Extended Essay
To make everything super clear, here are 100 Extended Essay Topics for you to draw inspiration from! Use these as a springboard to create your own research question !
Get Support from a Top Tutor Today
At Lanterna, we have over 300 tutors who smashed their Extended Essay. They know exactly how to get an A in your EE and can give you tips and tricks on how you can do the same. What are you waiting for? Get your own tutor today!
10 Steps to Writing an Extended Essay
Before we look at specific topics for your essay, let’s recap the 10-steps you’ll need to follow to complete your extended essay.
1. Define the Topic and Draft the Research Question
2. Create a Timeline
3. Identify and gather Sources
4. Set Deadlines
5. Plan the structure according to the total word count
6. Evaluate
7. independent Research
8. Write the extended essay draft
10. Present
By following the steps above, you should be able to produce a logical and coherent rationale to follow when writing the extended essay for your IB diploma programme.
By starting with a solid research question, you’ll be able to put an extended essay of global significance together, from the research and writing process all the way through to your final submission with a favourable extended essay grade.
Below, we’re sharing 10 topics across 10 subjects to inspire your next IB extended essay.
1. How the change of habitat affects an X organism?
2. How does climate affect the growth of X plant?
3. Can photosynthesis take place without sunlight?
4. What is the effect of age and gender on the photoreceptor cells in the human retina?
5. How is climate change impacting the appearance of coral reefs?
6. An evaluation of how antioxidants work in our bodies?
7. Does hand sanitizer, hand soap or antibacterial wipes have the greatest ability to inhibit the growth of E. Coli?
8. To what extent do live cultures in yogurts/milk/other dairy products reduce the concentration of lactose present over the course of a 2 hour incubation period at x°C?
9. What is the relationship between population density between X and population size of X?
10. What is the relationship between indoleacetic acid, a growth hormone, and the growth of X (a crop)?
11. How does human influence impact an aquatic ecosystem?
12. How can one organize a pollution check along a X canal in X?
13. What is the effect of the increased ecological footprint in the Amazon ?
14. What are the forest and woodland restoration in Siberia, Russia and which one is most effective?
15. How does human interference cause ecological imbalances in an X city/country/continent?
16. What is the impact of urban development on the bee population in X city?
17. What are the differences in the conversation efforts in Yosemite National Park (California, USA) and the Lake District National Park (UK)?
18. To what extent have healthcare policies in X country influenced their human population curve?
19. How have changes in environmental systems influenced the value system of X country?
20. How has X landfill site affected the surrounding terrestrial ecosystem?
21. What is the profitability of airline companies ?
22. How does unemployment affect the market?
23. Why did X recession occur?
24. How did the financial Policy affect the economy in X?
25. How effective are government policies in reducing overconsumption of alcohol (specifically hard liquor)?
26. To what extent are public buses and subways substitute goods in a country?
27. How did the tax reform in country x affect its growth and development? (many countries to choose from)
28. To what extent was weak government policy responsible for the Latin American financial crisis of 1997?
29. How effective is the Big Mac Index in measuring purchasing power parity?
30. To what extent would the UK suffer from leaving the European Customs Union if Brexit happens?
31. Is there an association between viewing violence on television and the display of violent acts?
32. What motivational climate should a coach employ in order to achieve optimal performance in athletes?
33. How does X hormone affect human behavior ?
34. Compare theories explaining altruism in human behaviour
35. Discuss short-term and long-term consequences of exposure to violence
36. Why do relationships change or end?
37. Discuss how social variables (poverty, parenting, educational environment) may the affect cognitive environment.
38. To what extent do mirror neurons play a role in empathy? (2014)
39. To what extent does Mindfulness help people cope with General Anxiety Disorder (GAD)?
40. To what extent is drug therapy effective in the treatment of bipolar disorder?
41. Does the British Parliamentary reforms act of 1832 deserve its title as the great reform act?
42. To what extent are there similarities in Hitler and Mussolini’s Rise to Power?
43. To what extent did Mao’s tackle the problems which he faced?
44. Was Tsar Alexander II of Russia reforms a success or failure?
45. To what extent was the bombing of Dresden in 1945 justifiable?
46. To what extent can Sweden be considered neutral during WWII ?
47. The impact of structural economic weakness on the collapse of the Soviet Union.
48. How were women treated differently in 1920s and 1950s Great Britain?
49. Why did Israel win the Six Day War of 1967?
50. What role did economics play in the unification of Germany from 1834 to 1871?
English Literature
51. What are the Compare and Contrast Jane Austen Books?
52. How does Joseph Conrad’s portray Racism in A Heart of Darkness?
53. How does Arthur Miller’s Death of a Salesman critique today’s capitalist society? The American Dream?
54. To what extent does Chris McCandless in Jon Krakauer’s Into the Wild escape familial influence?
55. What are the similarities and differences between J.K. Rowling’s characterization of Severus Snape in Harry Potter and the Philosopher’s Stone and Harry Potter and the Deathly Hallows?
56. How does Yaa Gyasi use structure in her novel Homegoing to portray the evolution of time?
57. What is the impact of the social context on Holden Caufield and Huckleberry Finn?
58. How does Sylvia Path’s use of Inanimate objects in Bell Jar?
59. How is the empowerment of Feminine portrayed in the Lord of the Rings?
60. Compare the political rhetoric as used in the inaugural addresses of George W. Bush, Barack Obama, and Donald Trump.
61. The design, construction and calibration of an apparatus for measuring lipid concentration in milk.
62. What is the effect of a change in the optimal lift on the horizontal gliding distance of an aircraft?
63. How does the sugar concentration affect the refractive index of water?
64. How does temperature affect the viscosity of X juice/soda?
65. Is the relationship between temperature and conductivity and insulators and conductors?
66. What is the Oberth Effect?
67. What is the temperature dependence of work performed on an AA battery?
68. How can the rotational frequency of a fan driven by a flame measure distance?
69. Do wine bottles of different shapes behave as Helmholtz resonators?
70. How does the diameter of a wheel affect stability in different weather conditions?
71. What factors influence the location of industries in country/city X?
72. An investigation into the significance of preserving the quality of water in a continent/country/city?
73. An investigation into the degree to which City X can be considered a Sustainable City/Community.
74. To what extent is Biodiversity being managed successfully in city X?
75. To what extent does the education and employment of women affect Country x’s fertility rate?
76. To what extent do gender, educational attainment, and working parameters influence obesity risk?
77. To what extent has urban development affected human thermal comfort levels in Country/city x (a country/city that has developed in a rapid rate over the past decades)?
78. To what extent is the Company x corporate waste management program effective, demonstrating environmental sustainability?
79. To what extent is biodiversity being managed successfully at National Park X?
80. What types of urban design encourage high rates of vandalism in X neighbourhoods?
81. The kinetics of Enzymatic Reactions.
82. How do Iron Intake Diets differ in X country?
83. What are the different factors that affect the iodine values in cooking oils?
84. What is the effect of standing time and temperate on the acid content in X juice or soda?
85. Can caffeine in tea or coffee be reduced?
86. What is the effect of temperature on the souring of milk?
87. What are the sources of error in calorimetry?
88. Does brushing your teeth affect the pH in your mouth after eating?
89. How does changing the concentration of the reagents affect the formation and spacing between Liesehang rings in the reaction between X chloride and X when conducted in a test tube?
90. What effect does the coating of aspirin tablets have on the hydrolysis of aspirin?
Social and Cultural Anthropology
91. How clothing relates to the cultural anthropology of X culture.
92. The extent to which social media networks affect different societies.
93. The relationship between ritual, myths and faith in an X society.
94. The history of rituals in X culture.
95. How different marriage rituals inform the cultural anthropology of X culture.
96. Climate change and its impact on the evolution of different creatures on the planet.
97. Understanding the social and cultural anthropology of the supernatural in X culture.
98. An analysis of body modification in relation to social and cultural anthropology.
100. Chaste systems and social ranks in societies.
There are so many class subjects that can form the basis of your extended essay, including these popular six subjects:
– Information technology
– Computer science
– Health science
– World studies
– Visual arts
– Business management
Extended essays are a great way to improve your writing skills in academic writing. Essays of a high standard that demonstrate critical thinking and in depth analysis can be submitted to academic journals. These have the potential to reach the global society.
Start Writing Your Extended Essay Topic
We hope this gave you some great inspiration for the variation of topics available for your Extended Essay . The research question you select is what will carry you through the entire process, so be sure to choose wisely!
Remember, if you are looking for more help with your Extended Essay, make sure to check out our guide which will tell you exactly how to plan, structure, research and write your Extended Essay!
Grab Free Extended Essay Resources!
No matter the subject groups in your diploma program, we’re here to help all of our IB students. Whether you’re writing about social and cultural anthropology, business management, design technology, or scientific methods for your IB diploma, Lanterna has you covered.
Share article links
Related Articles
25 History IA Topic Ideas!
Are you about to start your History internal assessment? We know the struggle. One of the most difficult parts about the task is finding a good History IA topic because it feels like you can just write about anything. The IB breaks it down into 7 main different types of topics that you can choose, […]
How to Finish Your Extended Essay Over Summer!
Completing their extended essay before they begin DP2 is the dream of most IB students. In reality, however, few achieve it. In this blog, we’ll explore how to finish your extended essay over summer without feeling overwhelmed! Part 1: Get Some Rest! Don’t forget that the reason you have a summer break is to take […]
Top 5 Essentials for Studying Physics
As the school year just started and some people are stressed about their upcoming journey in the IB Diploma Programme, we wanted to take the time to discuss perhaps one of the most infamous subjects for its difficulty … physics. It gets some bad rep and many people think that they’re just not “meant” for […]
IB World Studies EE examples
Filter exemplars, to what extent has the us semiconductor export curb to china, imposed in september-october 2022, impacted the usa and china’s economies, nvidia’s financial performance, and strategy plans, to what extent can mango pits be used as a biomass resource to heal the economic shortage of power supply in india, want to get full marks for your ee allow us to review it for you 🎯, to what extent does l’oréal’s investment in biogas as a bioenergy source allow them to maintain economic and environmental sustainability in france, how does the use of performance-enhancing drugs (peds) in high-level sports events affect an athlete’s health and career what is society’s perception towards doping in sports, to what extent did the establishment of thomson east coast line (tel) impact the property value of housing around tel and the economy of singapore between 2020 and 2023, fast track your coursework with mark schemes moderated by ib examiners. upgrade now 🚀, to what extent does the growing threat of ocean acidification impact tourism, analyzing the great barrier reef and areas of queensland, australia that border the great barrier reef, to what extent are bike lanes in metro vancouver effective, exploring the terra and aqua satellites’ contribution and roles in monitoring and controlling wildfires, to what extent did mexico9s power have an effect on covid-19 vaccine access, to what extent will the people's republic of china's domestic energy mix and consumption be able to contribute to the united nations’ sustainable development goal 7 while maintaining healthy economic growth by 2030, how have economic factors affected the biological consequences of "the cough syrup incident" in indonesia and how has it shaped the public health and cough syrup industry, to what extent will reliance's investment in bioenergy for the production of hydrogen as a biofuel through biomass gasification india influence its capacity to maintain both economic and environmental sustainability, an investigation into the economical and medical pros and cons derived from the growth of human gene editing, to what extent does the outbreak of covid-19 pandemic increase the inequality in the distribution of income within malaysia and what does the malaysian government do to help the lower income people , how do psychological factors and neural correlates contribute to radicalization to violence, specifically jihadism, to what extent do the government's initiatives of loan moratorium and the wage subsidy programme help the penang’s citizens financial burdens and employment of the tourism industry due to covid-19, to what extent can optimisation of a business allow for sustainable use of resources relating to the fashion industry, to what extent are the national security policies of the usa and pakistan similar or different in the areas of economic security and terrorism, to what extent has the usage of bitcoin and its practices impacted the economy and environment of kazakhstan, what gender discriminatory factors are responsible for the disproportionate rate of hiv infection among adolescent females in the region of sub-sahran africa, how does regulation in road transport engineering—traffic signals specifically—improve or deteriorate traffic safety in the netherlands and the us, to what extent is the impact of lead biomagnification in local food supply on the people in selangor, malaysia, how does the increase in water pollution impact the economic and ecological sustainability of the kolleru lake in andhra pradesh, to what extent is there a relationship between food allergies and anxiety in children and adolescents does this relationship have implications for treatment options, how did the loss of the gene patent case surrounding the discovery of the brca1 and brca2 by myriad impact the various stakeholders related to brca testing in the us, economics + ess: [32/34] “what impact did investment in renewable energy have on gujarat’s environmental sustainability and economic development since 2015”, how does pharmaceutical pollution by the discharge of drugs: diclofenac and propranolol, ecotoxicologically affect blue mussels (mytilus edulis) in himmerfjärden bay, sweden in the baltic proper, to what extent does diet and conformity cause japan's lower obesity rates compared to the usa, global politics and economics - a critical analysis on the rana plaza case study: to what extent are worker’s rights and standard labour conditions a priority in the ready-made garments sector of bangladesh, history and english: how have artists’ representations of the french revolution in media responded to transforming individuals and societies from 1789 - 2021, to what extent can the increased production of alternative proteins aid in achieving food security and economic growth in singapore, how do the cognitive biases of a consumer affect their behaviour in tourism flow in bali, to what extent did youth unemployment in post recession spain impact youths and what observed youth mental health issues surfaced during the same period, to what extent did the interim budgets implemented by the singapore government aid in the survival of food & beverage businesses during the pandemic in the year 2020, to what extent are genetically modified (gmo) sugarcane crops effective and sustainable in combating the sugarcane borer (diatraea saccharalis) and how do they affect the sugar and ethanol industry of brazil, environmental and/or economic sustainability: chemistry + ess - to what extent does the incorrect disposal of hexavalent chromium impact platanista gangetica gangetica in the river ganges, and does this pose an immediate threat to humans as well, what impact could the establishment of a potato-based biofuel industry have on bangladesh’s environmental and socioeconomic development.
- International
- Education Jobs
- Schools directory
- Resources Education Jobs Schools directory News Search
2025 Essay Preparation for A Level Biology AQA
Subject: Biology
Age range: 16+
Resource type: Lesson (complete)
Last updated
15 August 2024
- Share through email
- Share through twitter
- Share through linkedin
- Share through facebook
- Share through pinterest
This is the latest version, recently updated with the 2024 accessible essays.
CONTEXT: Every year, at least one Biology essay is very accessible, usually both are. This resource is to practise and revise for the accessible essay(s). It makes the preparation SPECIFIC, and EASY.
Included is + key revision of the 14 common topic areas (AO1) to learn. + written importance examples (AO2) to learn, from the 14 common topics. + a figure on how often each topic has appeared on essay mark schemes from 2017-2024. + a list of the accessible titles in the essays (from 2017-2024) + an easy-to-understand essay mark scheme
TEACHERS, use as a lesson resource, throughout upper 6, and as a preparation session before Paper 3. STUDENTS use for focussed revision and to practise writing essay paragraphs. You can even memorise paragraphs to rewrite.
All my students using this resource scored in double figures, with many scoring over 19/25.
Tes paid licence How can I reuse this?
Your rating is required to reflect your happiness.
It's good to leave some feedback.
Something went wrong, please try again later.
This resource hasn't been reviewed yet
To ensure quality for our reviews, only customers who have purchased this resource can review it
Report this resource to let us know if it violates our terms and conditions. Our customer service team will review your report and will be in touch.
Not quite what you were looking for? Search by keyword to find the right resource:
Information
Initiatives
You are accessing a machine-readable page. In order to be human-readable, please install an RSS reader.
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess .
Feature papers represent the most advanced research with significant potential for high impact in the field. A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications.
Feature papers are submitted upon individual invitation or recommendation by the scientific editors and must receive positive feedback from the reviewers.
Editor’s Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal.
Original Submission Date Received: .
- Active Journals
- Find a Journal
- Proceedings Series
- For Authors
- For Reviewers
- For Editors
- For Librarians
- For Publishers
- For Societies
- For Conference Organizers
- Open Access Policy
- Institutional Open Access Program
- Special Issues Guidelines
- Editorial Process
- Research and Publication Ethics
- Article Processing Charges
- Testimonials
- Preprints.org
- SciProfiles
- Encyclopedia
Article Menu
- Subscribe SciFeed
- Recommended Articles
- Google Scholar
- on Google Scholar
- Table of Contents
Find support for a specific problem in the support section of our website.
Please let us know what you think of our products and services.
Visit our dedicated information section to learn more about MDPI.
JSmol Viewer
Deciphering depression: epigenetic mechanisms and treatment strategies.
Simple Summary
1. introduction, background and significance, 2. epigenetic mechanisms (ems), 2.1. dna methylation, 2.2. histone modifications, 2.3. non-coding rnas, 3. epigenetic mechanisms in depression, 3.1. dna methylation and depression, 3.2. histone modifications and depression, 3.3. non-coding rnas and depression, 3.4. future directions, 4. dysregulation of non-coding rnas in depression, 4.1. functional consequences, 4.2. impact of non-coding rnas on gene expression, 5. environmental influences on epigenetic modifications, 5.1. prenatal environment, 5.2. early life stress, 5.3. parental care, 5.4. stress and depression, 6. epigenetics and treatment approaches, clinical applications of epigenetic research, 7. recent advances in epigenetic technologies, 8. summary and conclusions, author contributions, data availability statement, acknowledgments, conflicts of interest.
- Peña, C.J.; Nestler, E.J. Progress in epigenetics of depression. Prog. Mol. Biol. Transl. Sci. 2018 , 157 , 41–66. [ Google Scholar ]
- Cui, L.; Li, S.; Wang, S.; Wu, X.; Liu, Y.; Yu, W.; Wang, Y.; Tang, Y.; Xia, M.; Li, B. Major depressive disorder: Hypothesis, mechanism, prevention and treatment. Signal Transduct. Target. Ther. 2024 , 9 , 30. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Marx, W.; Penninx, B.; Solmi, M.; Furukawa, T.A.; Firth, J.; Carvalho, A.F.; Berk, M. Major depressive disorder. Nat. Rev. Dis. Primers 2023 , 9 , 44. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Alshaya, D.S. Genetic and epigenetic factors associated with depression: An updated overview. Saudi J. Biol. Sci. 2022 , 29 , 103311. [ Google Scholar ] [ CrossRef ]
- Gibney, E.R.; Nolan, C.M. Epigenetics and gene expression. Heredity 2010 , 105 , 4–13. [ Google Scholar ] [ CrossRef ]
- Al Aboud, N.M.; Tupper, C.; Jialal, I. Genetics, epigenetic mechanism. In StatPearls ; StatPearls Publishing: Treasure Island, FL, USA, 2018. [ Google Scholar ]
- Mohammadi, A.H.; Karimian, M.; Mirzaei, H.; Milajerdi, A. Epigenetic modifications and obsessive–compulsive disorder: What do we know? Brain Struct. Funct. 2023 , 228 , 1295–1305. [ Google Scholar ] [ CrossRef ]
- Jiang, S.; Postovit, L.; Cattaneo, A.; Binder, E.B.; Aitchison, K.J. Epigenetic Modifications in Stress Response Genes Associated with Childhood Trauma. Front. Psychiatry 2019 , 10 , 808. [ Google Scholar ] [ CrossRef ]
- Levy, M.J.F.; Boulle, F.; Steinbusch, H.W.; van den Hove, D.L.A.; Kenis, G.; Lanfumey, L. Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression. Psychopharmacology 2018 , 235 , 2195–2220. [ Google Scholar ] [ CrossRef ]
- Ortega, M.A.; Alvarez-Mon, M.A.; García-Montero, C.; Fraile-Martinez, O.; Lahera, G.; Monserrat, J.; Muñoz-Merida, L.; Mora, F.; Rodríguez-Jiménez, R.; Fernandez-Rojo, S.; et al. MicroRNAs as Critical Biomarkers of Major Depressive Disorder: A Comprehensive Perspective. Biomedicines 2021 , 9 , 1659. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Elhag, D.A.; Al Khodor, S. Exploring the potential of microRNA as a diagnostic tool for gestational diabetes. J. Transl. Med. 2023 , 21 , 392. [ Google Scholar ] [ CrossRef ]
- Martins de Carvalho, L.; Chen, W.Y.; Lasek, A.W. Epigenetic mechanisms underlying stress-induced depression. Int. Rev. Neurobiol. 2021 , 156 , 87–126. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Wu, M.S.; Li, X.J.; Liu, C.Y.; Xu, Q.; Huang, J.Q.; Gu, S.; Chen, J.X. Effects of Histone Modification in Major Depressive Disorder. Curr. Neuropharmacol. 2022 , 20 , 1261–1277. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Penner-Goeke, S.; Binder, E.B. Epigenetics and depression. Dialogues Clin. Neurosci. 2019 , 21 , 397–405. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Torres-Berrío, A.; Issler, O.; Parise, E.M.; Nestler, E.J. Unraveling the epigenetic landscape of depression: Focus on early life stress. Dialogues Clin. Neurosci. 2019 , 21 , 341–357. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Santaló, J.; Berdasco, M. Ethical Implications of Epigenetics in the Era of Personalized Medicine. Clin. Epigenetics 2022 , 14 , 44. [ Google Scholar ] [ CrossRef ]
- Roy, M.-C.; Dupras, C.; Ravitsky, V. The Epigenetic Effects of Assisted Reproductive Technologies: Ethical Considerations. J. Dev. Orig. Health Dis. 2017 , 8 , 436–442. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Dyke, S.O.M.; Saulnier, K.M.; Dupras, C.; Webster, A.D.B.; Maschke, K.J.; Rothstein, M.A.; Siebert, R.; Walter, J.; Beck, S.; Pastinen, T.; et al. Points-to-Consider on the Return of Results in Epigenetic Research. Genome Med. 2019 , 11 , 31. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Dupras, C.; Knoppers, T.; Palmour, N.; Beauchamp, E.; Liosi, S.; Siebert, R.; Berner, A.; Beck, S.; Charest, I.; Joly, Y. Researcher Perspectives on Ethics Considerations in Epigenetics: An International Survey. Clin. Epigenetics 2022 , 14 , 110. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Taki, F.; de Melo-Martín, I. Conducting Epigenetics Research With Refugees and Asylum Seekers: Attending to the Ethical Challenges. Clin. Epigenetics 2021 , 13 , 105. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Notterman, D.A.; Mitchell, C. Epigenetics and Understanding the Impact of Social Determinants of Health. Pediatr. Clin. N. Am. 2015 , 62 , 1227–1240. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Meloni, M. The social brain meets the reactive genome: Neuroscience, epigenetics and the new social biology. Front. Hum. Neurosci. 2014 , 8 , 309. [ Google Scholar ] [ CrossRef ]
- Beckedorff, F.C.; Amaral, M.S.; Deocesano-Pereira, C.; Verjovski-Almeida, S. Long non-coding RNAs and their implications in cancer epigenetics. Biosci. Rep. 2013 , 33 , e00061. [ Google Scholar ] [ CrossRef ]
- Berra, L. Existential Depression: A Nonpathological and Philosophical-Existential Approach. J. Humanist. Psychol. 2019 , 61 , 757–765. [ Google Scholar ] [ CrossRef ]
- Sjösten, M.; Hörberg, U.; Fagerström, C.; Tuvesson, H. Supporting recovery in persons with stress-related disorders: A reflective lifeworld research study of health care professionals in primary health care in Sweden. Int. J. Qual. Stud. Health Well-Being 2023 , 18 , 2209967. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Restifo, S. Existential depression: A meaningful diagnostic entity? Australas. Psychiatry 2023 , 31 , 502–504. [ Google Scholar ] [ CrossRef ]
- Bang, Y.; Lim, J.; Choi, H.J. Recent advances in the pathology of prodromal non-motor symptoms olfactory deficit and depression in Parkinson’s disease: Clues to early diagnosis and effective treatment. Arch. Pharmacal Res. 2021 , 44 , 588–604. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Lian, T.-H.; Guo, P.; Zuo, L.-J.; Hu, Y.; Yu, S.-Y.; Liu, L.; Jin, Z.; Yu, Q.-J.; Wang, R.-D.; Li, L.-X. An investigation on the clinical features and neurochemical changes in Parkinson’s disease with depression. Front. Psychiatry 2019 , 9 , 723. [ Google Scholar ] [ CrossRef ]
- Hemmerle, A.M.; Herman, J.P.; Seroogy, K.B. Stress, depression and Parkinson’s disease. Exp. Neurol. 2012 , 233 , 79–86. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Collaborators, G.M.D. Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry 2022 , 9 , 137–150. [ Google Scholar ] [ CrossRef ]
- Toth, M. Epigenetic neuropharmacology: Drugs affecting the epigenome in the brain. Annu. Rev. Pharmacol. Toxicol. 2021 , 61 , 181–201. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Nestler, E.J.; Peña, C.J.; Kundakovic, M.; Mitchell, A.; Akbarian, S. Epigenetic basis of mental illness. Neuroscientist 2016 , 22 , 447–463. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Handy, D.E.; Castro, R.; Loscalzo, J. Epigenetic modifications: Basic mechanisms and role in cardiovascular disease. Circulation 2011 , 123 , 2145–2156. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Kanwal, R.; Gupta, S. Epigenetic modifications in cancer. Clin. Genet. 2012 , 81 , 303–311. [ Google Scholar ] [ CrossRef ]
- Bure, I.V.; Nemtsova, M.V.; Kuznetsova, E.B. Histone Modifications and Non-Coding RNAs: Mutual Epigenetic Regulation and Role in Pathogenesis. Int. J. Mol. Sci. 2022 , 23 , 5801. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Salinas, R.D.; Connolly, D.R.; Song, H. Invited Review: Epigenetics in neurodevelopment. Neuropathol. Appl. Neurobiol. 2020 , 46 , 6–27. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Giacoman-Lozano, M.; Meléndez-Ramírez, C.; Martinez-Ledesma, E.; Cuevas-Diaz Duran, R.; Velasco, I. Epigenetics of neural differentiation: Spotlight on enhancers. Front. Cell Dev. Biol. 2022 , 10 , 1001701. [ Google Scholar ] [ CrossRef ]
- Klengel, T.; Binder, E.B. Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions. Neuron 2015 , 86 , 1343–1357. [ Google Scholar ] [ CrossRef ]
- Lee, S.-A.; Huang, K.-C. Epigenetic profiling of human brain differential DNA methylation networks in schizophrenia. BMC Med. Genom. 2016 , 9 , 68. [ Google Scholar ] [ CrossRef ]
- Cecil, C.A.M.; Neumann, A.; Walton, E. Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities. JCPP Adv. 2023 , 3 , e12133. [ Google Scholar ] [ CrossRef ]
- Peedicayil, J. Genome–Environment Interactions and Psychiatric Disorders. Biomedicines 2023 , 11 , 1209. [ Google Scholar ] [ CrossRef ]
- Tirado-Magallanes, R.; Rebbani, K.; Lim, R.; Pradhan, S.; Benoukraf, T. Whole genome DNA methylation: Beyond genes silencing. Oncotarget 2017 , 8 , 5629. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Fries, G.R.; Li, Q.; McAlpin, B.; Rein, T.; Walss-Bass, C.; Soares, J.C.; Quevedo, J. The role of DNA methylation in the pathophysiology and treatment of bipolar disorder. Neurosci. Biobehav. Rev. 2016 , 68 , 474–488. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Herrera-Rivero, M.; Gutiérrez-Fragoso, K.; Stoll, M.; Baune, B.T.; Berger, K. DNA methylation links between depression and immunity. J. Affect. Disord. Rep. 2023 , 12 , 100546. [ Google Scholar ] [ CrossRef ]
- Saavedra, K.; Molina-Márquez, A.M.; Saavedra, N.; Zambrano, T.; Salazar, L.A. Epigenetic Modifications of Major Depressive Disorder. Int. J. Mol. Sci. 2016 , 17 , 1279. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Xing, Y.; Sun, T.; Li, G.; Xu, G.; Cheng, J.; Gao, S. The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value. J. Clin. Lab. Anal. 2021 , 35 , e23993. [ Google Scholar ] [ CrossRef ]
- Arosio, B.; Guerini, F.R.; Voshaar, R.C.O.; Aprahamian, I. Blood Brain-Derived Neurotrophic Factor (BDNF) and Major Depression: Do We Have a Translational Perspective? Front. Behav. Neurosci. 2021 , 15 , 626906. [ Google Scholar ] [ CrossRef ]
- Šalamon Arčan, I.; Kouter, K.; Videtič Paska, A. Depressive disorder and antidepressants from an epigenetic point of view. World J. Psychiatry 2022 , 12 , 1150–1168. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- de Mendoza, A.; Nguyen, T.V.; Ford, E.; Poppe, D.; Buckberry, S.; Pflueger, J.; Grimmer, M.R.; Stolzenburg, S.; Bogdanovic, O.; Oshlack, A.; et al. Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability. Genome Biol. 2022 , 23 , 163. [ Google Scholar ] [ CrossRef ]
- Czarny, P.; Białek, K.; Ziółkowska, S.; Strycharz, J.; Barszczewska, G.; Sliwinski, T. The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder. J. Pers. Med. 2021 , 11 , 167. [ Google Scholar ] [ CrossRef ]
- Zhu, J.-H.; Bo, H.-H.; Liu, B.-P.; Jia, C.-X. The associations between DNA methylation and depression: A systematic review and meta-analysis. J. Affect. Disord. 2023 , 327 , 439–450. [ Google Scholar ] [ CrossRef ]
- Hüls, A.; Robins, C.; Conneely, K.N.; De Jager, P.L.; Bennett, D.A.; Epstein, M.P.; Wingo, T.S.; Wingo, A.P. Association between DNA methylation levels in brain tissue and late-life depression in community-based participants. Transl. Psychiatry 2020 , 10 , 262. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Chen, D.; Meng, L.; Pei, F.; Zheng, Y.; Leng, J. A review of DNA methylation in depression. J. Clin. Neurosci. 2017 , 43 , 39–46. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Zhao, J.; Goldberg, J.; Bremner, J.D.; Vaccarino, V. Association between promoter methylation of serotonin transporter gene and depressive symptoms: A monozygotic twin study. Psychosom. Med. 2013 , 75 , 523–529. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Ren, W.; Gao, L.; Song, J. Structural basis of DNMT1 and DNMT3A-mediated DNA methylation. Genes 2018 , 9 , 620. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Fuchikami, M.; Morinobu, S.; Segawa, M.; Okamoto, Y.; Yamawaki, S.; Ozaki, N.; Inoue, T.; Kusumi, I.; Koyama, T.; Tsuchiyama, K.; et al. DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. PLoS ONE 2011 , 6 , e23881. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Lin, E.; Tsai, S.J. Epigenetics and Depression: An Update. Psychiatry Investig. 2019 , 16 , 654. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Holloway, C.; González-Maeso, J. Epigenetic Mechanisms of Serotonin Signaling. ACS Chem. Neurosci. 2015 , 6 , 1099–1109. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- He, H.; Hu, Z.; Xiao, H.; Zhou, F.; Yang, B. The tale of histone modifications and its role in multiple sclerosis. Hum. Genom. 2018 , 12 , 31. [ Google Scholar ] [ CrossRef ]
- Lu, C.; Coradin, M.; Porter, E.G.; Garcia, B.A. Accelerating the Field of Epigenetic Histone Modification through Mass Spectrometry-Based Approaches. Mol. Cell. Proteom. 2021 , 20 , 100006. [ Google Scholar ] [ CrossRef ]
- Cavalieri, V. The Expanding Constellation of Histone Post-Translational Modifications in the Epigenetic Landscape. Genes 2021 , 12 , 1596. [ Google Scholar ] [ CrossRef ]
- Gammoh, O.; Aljabali, A.A.A.; Tambuwala, M.M. Plasma amino acids in major depressive disorder: Between pathology to pharmacology. EXCLI J. 2024 , 23 , 62–78. [ Google Scholar ] [ CrossRef ]
- Park, J.; Lee, K.; Kim, K.; Yi, S.-J. The role of histone modifications: From neurodevelopment to neurodiseases. Signal Transduct. Target. Ther. 2022 , 7 , 217. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Gujral, P.; Mahajan, V.; Lissaman, A.C.; Ponnampalam, A.P. Histone acetylation and the role of histone deacetylases in normal cyclic endometrium. Reprod. Biol. Endocrinol. 2020 , 18 , 84. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Miller, J.L.; Grant, P.A. The role of DNA methylation and histone modifications in transcriptional regulation in humans. Subcell. Biochem. 2013 , 61 , 289–317. [ Google Scholar ] [ CrossRef ]
- Bannister, A.J.; Kouzarides, T. Regulation of chromatin by histone modifications. Cell Res. 2011 , 21 , 381–395. [ Google Scholar ] [ CrossRef ]
- Zhang, T.; Cooper, S.; Brockdorff, N. The interplay of histone modifications-writers that read. EMBO Rep. 2015 , 16 , 1467–1481. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Lutz, P.-E.; Chay, M.-A.; Pacis, A.; Chen, G.G.; Aouabed, Z.; Maffioletti, E.; Théroux, J.-F.; Grenier, J.-C.; Yang, J.; Aguirre, M.; et al. Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation. Nat. Commun. 2021 , 12 , 1132. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Sanbonmatsu, D.M.; Cooley, E.H.; Butner, J.E. The Impact of Complexity on Methods and Findings in Psychological Science. Front. Psychol. 2020 , 11 , 580111. [ Google Scholar ] [ CrossRef ]
- Dong, X.; Weng, Z. The correlation between histone modifications and gene expression. Epigenomics 2013 , 5 , 113–116. [ Google Scholar ] [ CrossRef ]
- Dent, S.Y.R. Grand challenge in chromatin epigenomics: Everything, everywhere, all at once. Front. Epigenet. Epigenom. 2023 , 1 , 1195690. [ Google Scholar ] [ CrossRef ]
- Galow, A.M.; Peleg, S. How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span. Cells 2022 , 11 , 468. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Erfanian, N.; Heydari, A.A.; Feriz, A.M.; Iañez, P.; Derakhshani, A.; Ghasemigol, M.; Farahpour, M.; Razavi, S.M.; Nasseri, S.; Safarpour, H.; et al. Deep learning applications in single-cell genomics and transcriptomics data analysis. Biomed. Pharmacother. 2023 , 165 , 115077. [ Google Scholar ] [ CrossRef ]
- Ratti, M.; Lampis, A.; Ghidini, M.; Salati, M.; Mirchev, M.B.; Valeri, N.; Hahne, J.C. MicroRNAs (miRNAs) and Long Non-Coding RNAs (lncRNAs) as New Tools for Cancer Therapy: First Steps from Bench to Bedside. Target. Oncol. 2020 , 15 , 261–278. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Sati, S.; Ghosh, S.; Jain, V.; Scaria, V.; Sengupta, S. Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci. Nucleic Acids Res. 2012 , 40 , 10018–10031. [ Google Scholar ] [ CrossRef ]
- O’Brien, J.; Hayder, H.; Zayed, Y.; Peng, C. Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation. Front. Endocrinol. (Lausanne) 2018 , 9 , 402. [ Google Scholar ] [ CrossRef ]
- Annese, T.; Tamma, R.; De Giorgis, M.; Ribatti, D. microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis. Front. Oncol. 2020 , 10 , 581007. [ Google Scholar ] [ CrossRef ]
- Statello, L.; Guo, C.-J.; Chen, L.-L.; Huarte, M. Gene regulation by long non-coding RNAs and its biological functions. Nat. Rev. Mol. Cell Biol. 2021 , 22 , 96–118. [ Google Scholar ] [ CrossRef ]
- Li, Z.; Zhao, W.; Wang, M.; Zhou, X. The role of long noncoding RNAs in gene expression regulation. In Gene Expression Profiling in Cancer ; IntechOpen Limited: London, UK, 2019; pp. 1–17. [ Google Scholar ]
- Hanly, D.J.; Esteller, M.; Berdasco, M. Interplay between long non-coding RNAs and epigenetic machinery: Emerging targets in cancer? Philos. Trans. R. Soc. B Biol. Sci. 2018 , 373 , 20170074. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Aliperti, V.; Skonieczna, J.; Cerase, A. Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders. Non-Coding RNA 2021 , 7 , 36. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Zhang, G.; Lan, Y.; Xie, A.; Shi, J.; Zhao, H.; Xu, L.; Zhu, S.; Luo, T.; Zhao, T.; Xiao, Y. Comprehensive analysis of long noncoding RNA (lncRNA)-chromatin interactions reveals lncRNA functions dependent on binding diverse regulatory elements. J. Biol. Chem. 2019 , 294 , 15613–15622. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Zhao, H.; Liu, X.; Yu, L.; Lin, S.; Zhang, C.; Xu, H.; Leng, Z.; Huang, W.; Lei, J.; Li, T. Comprehensive landscape of epigenetic-dysregulated lncRNAs reveals a profound role of enhancers in carcinogenesis in BC subtypes. Mol. Ther.-Nucleic Acids 2021 , 23 , 667–681. [ Google Scholar ] [ CrossRef ]
- Dahrendorff, J.; Currier, G.; Uddin, M. Leveraging DNA methylation to predict treatment response in major depressive disorder: A critical review. Am. J. Med. Genet. Part B Neuropsychiatr. Genet. 2024 , e32985. [ Google Scholar ] [ CrossRef ]
- Kowiański, P.; Lietzau, G.; Czuba, E.; Waśkow, M.; Steliga, A.; Moryś, J. BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity. Cell. Mol. Neurobiol. 2018 , 38 , 579–593. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Notaras, M.; van den Buuse, M. Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders. Mol. Psychiatry 2020 , 25 , 2251–2274. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Patnaik, E.; Madu, C.; Lu, Y. Epigenetic modulators as therapeutic agents in cancer. Int. J. Mol. Sci. 2023 , 24 , 14964. [ Google Scholar ] [ CrossRef ]
- Maze, I.; Covington, H.E., 3rd; Dietz, D.M.; LaPlant, Q.; Renthal, W.; Russo, S.J.; Mechanic, M.; Mouzon, E.; Neve, R.L.; Haggarty, S.J.; et al. Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science 2010 , 327 , 213–216. [ Google Scholar ] [ CrossRef ]
- Castillo-Aguilera, O.; Depreux, P.; Halby, L.; Arimondo, P.B.; Goossens, L. DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge. Biomolecules 2017 , 7 , 3. [ Google Scholar ] [ CrossRef ]
- Uddin, M.G.; Fandy, T.E. Chapter Five-DNA methylation inhibitors: Retrospective and perspective view. In Advances in Cancer Research ; Tew, K.D., Fisher, P.B., Eds.; Academic Press: Cambridge, MA, USA, 2021; Volume 152, pp. 205–223. [ Google Scholar ]
- Haggerty, C.; Kretzmer, H.; Riemenschneider, C.; Kumar, A.S.; Mattei, A.L.; Bailly, N.; Gottfreund, J.; Giesselmann, P.; Weigert, R.; Brändl, B.; et al. Dnmt1 has de novo activity targeted to transposable elements. Nat. Struct. Mol. Biol. 2021 , 28 , 594–603. [ Google Scholar ] [ CrossRef ]
- Wan, Q.; Gao, K.; Rong, H.; Wu, M.; Wang, H.; Wang, X.; Wang, G.; Liu, Z. Histone modifications of the Crhr1 gene in a rat model of depression following chronic stress. Behav. Brain Res. 2014 , 271 , 1–6. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Tsankova, N.M.; Kumar, A.; Nestler, E.J. Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J. Neurosci. 2004 , 24 , 5603–5610. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Cruceanu, C.; Alda, M.; Nagy, C.; Freemantle, E.; Rouleau, G.A.; Turecki, G. H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression. Int. J. Neuropsychopharmacol. 2013 , 16 , 289–299. [ Google Scholar ] [ CrossRef ]
- Rinn, J.L.; Chang, H.Y. Long Noncoding RNAs: Molecular Modalities to Organismal Functions. Annu. Rev. Biochem. 2020 , 89 , 283–308. [ Google Scholar ] [ CrossRef ]
- Zhang, Y.; Liu, H.; Niu, M.; Wang, Y.; Xu, R.; Guo, Y.; Zhang, C. Roles of long noncoding RNAs in human inflammatory diseases. Cell Death Discov. 2024 , 10 , 235. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Zhang, L.; Pan, J.; Chen, W.; Jiang, J.; Huang, J. Chronic stress-induced immune dysregulation in cancer: Implications for initiation, progression, metastasis, and treatment. Am. J. Cancer Res. 2020 , 10 , 1294–1307. [ Google Scholar ] [ PubMed ]
- Hakami, M.A.; Hazazi, A.; Abdulaziz, O.; Almasoudi, H.H.; Alhazmi, A.Y.M.; Alkhalil, S.S.; Alharthi, N.S.; Alhuthali, H.M.; Almalki, W.H.; Gupta, G.; et al. HOTAIR: A key regulator of the Wnt/β-catenin signaling cascade in cancer progression and treatment. Pathol. Res. Pract. 2024 , 253 , 154957. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Anilkumar, A.K.; Vij, P.; Lopez, S.; Leslie, S.M.; Doxtater, K.; Khan, M.M.; Yallapu, M.M.; Chauhan, S.C.; Maestre, G.E.; Tripathi, M.K. Long Non-Coding RNAs: New Insights in Neurodegenerative Diseases. Int. J. Mol. Sci. 2024 , 25 , 2268. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Mattick, J.S.; Amaral, P.P.; Carninci, P.; Carpenter, S.; Chang, H.Y.; Chen, L.L.; Chen, R.; Dean, C.; Dinger, M.E.; Fitzgerald, K.A.; et al. Long non-coding RNAs: Definitions, functions, challenges and recommendations. Nat. Rev. Mol. Cell Biol. 2023 , 24 , 430–447. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Sebastian-delaCruz, M.; Gonzalez-Moro, I.; Olazagoitia-Garmendia, A.; Castellanos-Rubio, A.; Santin, I. The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization. Non-Coding RNA 2021 , 7 , 3. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Long, F.; Li, X.; Pan, J.; Ye, H.; Di, C.; Huang, Y.; Li, J.; Zhou, X.; Yi, H.; Huang, Q.; et al. The role of lncRNA NEAT1 in human cancer chemoresistance. Cancer Cell Int. 2024 , 24 , 236. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Yrondi, A.; Fiori, L.M.; Nogovitsyn, N.; Hassel, S.; Théroux, J.F.; Aouabed, Z.; Frey, B.N.; Lam, R.W.; Milev, R.; Müller, D.J.; et al. Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: A CAN-BIND 1 report. Transl. Psychiatry 2021 , 11 , 469. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Fernandes, J.C.R.; Acuña, S.M.; Aoki, J.I.; Floeter-Winter, L.M.; Muxel, S.M. Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease. Non-Coding RNA 2019 , 5 , 17. [ Google Scholar ] [ CrossRef ]
- Lin, R.; Turecki, G. Noncoding RNAs in Depression. In Neuroepigenomics in Aging and Disease ; Delgado-Morales, R., Ed.; Springer International Publishing: Cham, Switzerland, 2017; pp. 197–210. [ Google Scholar ]
- Spadaro, P.A.; Bredy, T.W. Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders. Front. Genet. 2012 , 3 , 132. [ Google Scholar ] [ CrossRef ]
- Gomes, A.Q.; Nolasco, S.; Soares, H. Non-coding RNAs: Multi-tasking molecules in the cell. Int. J. Mol. Sci. 2013 , 14 , 16010–16039. [ Google Scholar ] [ CrossRef ]
- Li, Q.; Su, Z.; Xu, X.; Liu, G.; Song, X.; Wang, R.; Sui, X.; Liu, T.; Chang, X.; Huang, D. AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans. Proc. Natl. Acad. Sci. USA 2012 , 109 , 14110–14115. [ Google Scholar ] [ CrossRef ]
- Løkhammer, S.; Stavrum, A.-K.; Polushina, T.; Aas, M.; Ottesen, A.A.; Andreassen, O.A.; Melle, I.; Le Hellard, S. An epigenetic association analysis of childhood trauma in psychosis reveals possible overlap with methylation changes associated with PTSD. Transl. Psychiatry 2022 , 12 , 177. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Booij, L.; Szyf, M.; Carballedo, A.; Frey, E.-M.; Morris, D.; Dymov, S.; Vaisheva, F.; Ly, V.; Fahey, C.; Meaney, J. DNA methylation of the serotonin transporter gene in peripheral cells and stress-related changes in hippocampal volume: A study in depressed patients and healthy controls. PLoS ONE 2015 , 10 , e0119061. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Ferrer, A.; Labad, J.; Salvat-Pujol, N.; Barrachina, M.; Costas, J.; Urretavizcaya, M.; de Arriba-Arnau, A.; Crespo, J.M.; Soriano-Mas, C.; Carracedo, Á.; et al. BDNF genetic variants and methylation: Effects on cognition in major depressive disorder. Transl. Psychiatry 2019 , 9 , 265. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Wang, W.; Li, W.; Wu, Y.; Tian, X.; Duan, H.; Li, S.; Tan, Q.; Zhang, D. Genome-wide DNA methylation and gene expression analyses in monozygotic twins identify potential biomarkers of depression. Transl. Psychiatry 2021 , 11 , 416. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Zhu, Y.; Strachan, E.; Fowler, E.; Bacus, T.; Roy-Byrne, P.; Zhao, J. Genome-wide profiling of DNA methylome and transcriptome in peripheral blood monocytes for major depression: A Monozygotic Discordant Twin Study. Transl. Psychiatry 2019 , 9 , 215. [ Google Scholar ] [ CrossRef ]
- Sato, S.; Bunney, B.; Mendoza-Viveros, L.; Bunney, W.; Borrelli, E.; Sassone-Corsi, P.; Orozco-Solis, R. Rapid-acting antidepressants and the circadian clock. Neuropsychopharmacology 2022 , 47 , 805–816. [ Google Scholar ] [ CrossRef ]
- Dwivedi, Y. MicroRNAs in depression and suicide: Recent insights and future perspectives. J. Affect. Disord. 2018 , 240 , 146–154. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Roy, B.; Ochi, S.; Dwivedi, Y. Potential of Circulating miRNAs as Molecular Markers in Mood Disorders and Associated Suicidal Behavior. Int. J. Mol. Sci. 2023 , 24 , 4664. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Zhou, Y.; Lutz, P.E.; Wang, Y.C.; Ragoussis, J.; Turecki, G. Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides. Transl. Psychiatry 2018 , 8 , 224. [ Google Scholar ] [ CrossRef ]
- Shi, Y.; Wang, Q.; Song, R.; Kong, Y.; Zhang, Z. Non-coding RNAs in depression: Promising diagnostic and therapeutic biomarkers. EBioMedicine 2021 , 71 , 103569. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Uchida, S.; Yamagata, H.; Seki, T.; Watanabe, Y. Epigenetic mechanisms of major depression: Targeting neuronal plasticity. Psychiatry Clin. Neurosci. 2018 , 72 , 212–227. [ Google Scholar ] [ CrossRef ]
- Thapa, R.; Sparks, F.T.; Hanif, W.; Gulbrandsen, T.; Sutherland, R.J. Recent memory for socially transmitted food preferences in rats does not depend on the hippocampus. Neurobiol. Learn. Mem. 2014 , 114 , 113–116. [ Google Scholar ] [ CrossRef ]
- Egervari, G. Chromatin accessibility in neuropsychiatric disorders. Neurobiol. Learn. Mem. 2021 , 181 , 107438. [ Google Scholar ] [ CrossRef ]
- Huisman, S.G.; van der Veen, R.C.A.; Sun, C.; Lohse, D. Multiple states in highly turbulent Taylor–Couette flow. Nat. Commun. 2014 , 5 , 3820. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Aberg, K.A.; Dean, B.; Shabalin, A.A.; Chan, R.F.; Han, L.K.M.; Zhao, M.; van Grootheest, G.; Xie, L.Y.; Milaneschi, Y.; Clark, S.L.; et al. Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples. Mol. Psychiatry 2020 , 25 , 1344–1354. [ Google Scholar ] [ CrossRef ]
- Yamagata, H.; Ogihara, H.; Matsuo, K.; Uchida, S.; Kobayashi, A.; Seki, T.; Kobayashi, M.; Harada, K.; Chen, C.; Miyata, S.; et al. Distinct epigenetic signatures between adult-onset and late-onset depression. Sci. Rep. 2021 , 11 , 2296. [ Google Scholar ] [ CrossRef ]
- Starnawska, A.; Demontis, D. Role of DNA Methylation in Mediating Genetic Risk of Psychiatric Disorders. Front. Psychiatry 2021 , 12 , 596821. [ Google Scholar ] [ CrossRef ]
- Barbon, A.; Magri, C. RNA Editing and Modifications in Mood Disorders. Genes 2020 , 11 , 872. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Salvetat, N.; Checa-Robles, F.J.; Patel, V.; Cayzac, C.; Dubuc, B.; Chimienti, F.; Abraham, J.D.; Dupré, P.; Vetter, D.; Méreuze, S.; et al. A game changer for bipolar disorder diagnosis using RNA editing-based biomarkers. Transl. Psychiatry 2022 , 12 , 182. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Hu, G. Evaluation of 3D Chromatin Interactions Using Hi-C. Methods Mol. Biol. 2020 , 2117 , 65–78. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Krishnan, V.; Nestler, E.J. Animal models of depression: Molecular perspectives. Curr. Top. Behav. Neurosci. 2011 , 7 , 121–147. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Shadrina, M.; Bondarenko, E.A.; Slominsky, P.A. Genetics Factors in Major Depression Disease. Front. Psychiatry 2018 , 9 , 334. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Dion, A.; Muñoz, P.T.; Franklin, T.B. Epigenetic mechanisms impacted by chronic stress across the rodent lifespan. Neurobiol. Stress 2022 , 17 , 100434. [ Google Scholar ] [ CrossRef ]
- Li, M.; Fu, X.; Xie, W.; Guo, W.; Li, B.; Cui, R.; Yang, W. Effect of Early Life Stress on the Epigenetic Profiles in Depression. Front. Cell Dev. Biol. 2020 , 8 , 867. [ Google Scholar ] [ CrossRef ]
- Ochi, S.; Dwivedi, Y. Dissecting early life stress-induced adolescent depression through epigenomic approach. Mol. Psychiatry 2023 , 28 , 141–153. [ Google Scholar ] [ CrossRef ]
- Nestler, E.J. Epigenetic mechanisms of depression. JAMA Psychiatry 2014 , 71 , 454–456. [ Google Scholar ] [ CrossRef ]
- Schell, G.; Roy, B.; Prall, K.; Dwivedi, Y. miR-218: A Stress-Responsive Epigenetic Modifier. Non-Coding RNA 2022 , 8 , 55. [ Google Scholar ] [ CrossRef ]
- Zhu, Z.; Huang, X.; Du, M.; Wu, C.; Fu, J.; Tan, W.; Wu, B.; Zhang, J.; Liao, Z.B. Recent advances in the role of miRNAs in post-traumatic stress disorder and traumatic brain injury. Mol. Psychiatry 2023 , 28 , 2630–2644. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Zhao, H.; Wang, L.; Zhang, L.; Zhao, H. Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders. Biomed. Pharmacother. 2023 , 162 , 114692. [ Google Scholar ] [ CrossRef ]
- Zhang, S.-F.; Gao, J.; Liu, C.-M. The role of non-coding RNAs in neurodevelopmental disorders. Front. Genet. 2019 , 10 , 1033. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Rahmani, S.; Kadkhoda, S.; Ghafouri-Fard, S. Synaptic plasticity and depression: The role of miRNAs dysregulation. Mol. Biol. Rep. 2022 , 49 , 9759–9765. [ Google Scholar ] [ CrossRef ]
- Ding, R.; Su, D.; Zhao, Q.; Wang, Y.; Wang, J.-Y.; Lv, S.; Ji, X. The role of microRNAs in depression. Front. Pharmacol. 2023 , 14 , 1129186. [ Google Scholar ] [ CrossRef ]
- Mongelli, A.; Martelli, F.; Farsetti, A.; Gaetano, C. The Dark That Matters: Long Non-Coding RNAs as Master Regulators of Cellular Metabolism in Non-Communicable Diseases. Front. Physiol. 2019 , 10 , 369. [ Google Scholar ] [ CrossRef ]
- Winkle, M.; El-Daly, S.M.; Fabbri, M.; Calin, G.A. Noncoding RNA therapeutics-challenges and potential solutions. Nat. Rev. Drug Discov. 2021 , 20 , 629–651. [ Google Scholar ] [ CrossRef ]
- Khorkova, O.; Stahl, J.; Joji, A.; Volmar, C.-H.; Wahlestedt, C. Amplifying gene expression with RNA-targeted therapeutics. Nat. Rev. Drug Discov. 2023 , 22 , 539–561. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Liu, Z.; Gao, L.; Cheng, L.; Lv, G.; Sun, B.; Wang, G.; Tang, Q. The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: Classification, mechanisms, and potential therapeutic implications. Exp. Mol. Med. 2023 , 55 , 487–501. [ Google Scholar ] [ CrossRef ]
- Liu, Y.; Yang, D.; Liu, T.; Chen, J.; Yu, J.; Yi, P. N6-methyladenosine-mediated gene regulation and therapeutic implications. Trends Mol. Med. 2023 , 29 , 454–467. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Wang, Q.; Roy, B.; Dwivedi, Y.K. Co-Expression Network Modeling Identifies Key Long Non-Coding RNA and mRNA Modules in Altering Molecular Phenotype to Develop Stress-Induced Depression in Rats. Transl. Psychiatry 2019 , 9 , 125. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Glăvan, D.; Gheorman, V.; Gresita, A.; Hermann, D.M.; Udriștoiu, I.; Popa-Wagner, A. Identification of Transcriptome Alterations in the Prefrontal Cortex, Hippocampus, Amygdala and Hippocampus of Suicide Victims. Sci. Rep. 2021 , 11 , 18853. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- García-Fonseca, Á.; Martin-Jimenez, C.; Barreto, G.E.; Pachón, A.F.A.; González, J. The Emerging Role of Long Non-Coding RNAs and MicroRNAs in Neurodegenerative Diseases: A Perspective of Machine Learning. Biomolecules 2021 , 11 , 1132. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Lewis, C.R.; Olive, M.F. Early-life stress interactions with the epigenome: Potential mechanisms driving vulnerability toward psychiatric illness. Behav. Pharmacol. 2014 , 25 , 341–351. [ Google Scholar ] [ CrossRef ]
- Cheng, Z.; Su, J.; Zhang, K.; Jiang, H.-B.; Li, B. Epigenetic Mechanism of Early Life Stress-Induced Depression: Focus on the Neurotransmitter Systems. Front. Cell Dev. Biol. 2022 , 10 , 929732. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Uchida, S.; Hara, K.; Kobayashi, A.; Otsuki, K.; Yamagata, H.; Hobara, T.; Suzuki, T.; Miyata, N.; Watanabe, Y. Epigenetic Status of GDNF in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events. Neuron 2011 , 69 , 359–372. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Kundakovic, M.; Jaric, I. The Epigenetic Link between Prenatal Adverse Environments and Neurodevelopmental Disorders. Genes 2017 , 8 , 104. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Tiffon, C. The Impact of Nutrition and Environmental Epigenetics on Human Health and Disease. Int. J. Mol. Sci. 2018 , 19 , 3425. [ Google Scholar ] [ CrossRef ]
- Kertes, D.A.; Kamin, H.S.; Hughes, D.A.; Rodney, N.C.; Bhatt, S.; Mulligan, C.J. Prenatal Maternal Stress Predicts Methylation of Genes Regulating the Hypothalamic-Pituitary-Adrenocortical System in Mothers and Newborns in the Democratic Republic of Congo. Child Dev. 2016 , 87 , 61–72. [ Google Scholar ] [ CrossRef ]
- Perera, F.; Herbstman, J. Prenatal environmental exposures, epigenetics, and disease. Reprod. Toxicol. 2011 , 31 , 363–373. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Kundakovic, M.; Champagne, F.A. Early-life experience, epigenetics, and the developing brain. Neuropsychopharmacology 2015 , 40 , 141–153. [ Google Scholar ] [ CrossRef ]
- Parade, S.H.; Huffhines, L.; Daniels, T.E.; Stroud, L.R.; Nugent, N.R.; Tyrka, A.R. A systematic review of childhood maltreatment and DNA methylation: Candidate gene and epigenome-wide approaches. Transl. Psychiatry 2021 , 11 , 134. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Quidé, Y.; Tozzi, L.; Corcoran, M.; Cannon, D.M.; Dauvermann, M.R. The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress. Neuropsychiatr. Dis. Treat. 2020 , 16 , 3095–3115. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Nie, Y.; Wen, L.; Song, J.; Wang, N.; Huang, L.; Gao, L.; Qu, M. Emerging trends in epigenetic and childhood trauma: Bibliometrics and visual analysis. Front. Psychiatry 2022 , 13 , 925273. [ Google Scholar ] [ CrossRef ]
- Thumfart, K.M.; Jawaid, A.; Bright, K.; Flachsmann, M.; Mansuy, I.M. Epigenetics of childhood trauma: Long term sequelae and potential for treatment. Neurosci. Biobehav. Rev. 2022 , 132 , 1049–1066. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Murgatroyd, C.; Spengler, D. Epigenetics of early child development. Front. Psychiatry 2011 , 2 , 16. [ Google Scholar ] [ CrossRef ]
- Soga, T.; Teo, C.H.; Parhar, I. Genetic and Epigenetic Consequence of Early-Life Social Stress on Depression: Role of Serotonin-Associated Genes. Front. Genet. 2021 , 11 , 601868. [ Google Scholar ] [ CrossRef ]
- Park, C.; Rosenblat, J.D.; Brietzke, E.; Pan, Z.; Lee, Y.; Cao, B.; Zuckerman, H.; Kalantarova, A.; McIntyre, R.S. Stress, epigenetics and depression: A systematic review. Neurosci. Biobehav. Rev. 2019 , 102 , 139–152. [ Google Scholar ] [ CrossRef ]
- Poon, C.H.; Heng, B.C.; Lim, L.W. New insights on brain-derived neurotrophic factor epigenetics: From depression to memory extinction. Ann. N. Y. Acad. Sci. 2021 , 1484 , 9–31. [ Google Scholar ] [ CrossRef ]
- Schroeder, M.; Krebs, M.O.; Bleich, S.; Frieling, H. Epigenetics and depression: Current challenges and new therapeutic options. Curr. Opin. Psychiatry 2010 , 23 , 588–592. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Menke, A.; Binder, E.B. Epigenetic alterations in depression and antidepressant treatment. Dialogues Clin. Neurosci. 2014 , 16 , 395–404. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Lee, J.S.; Jaini, P.A.; Papa, F. An Epigenetic Perspective on Lifestyle Medicine for Depression: Implications for Primary Care Practice. Am. J. Lifestyle Med. 2022 , 16 , 76–88. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Yuan, C.; Cai, H.; Wang, M.; Ma, X.; Mo, F.; Yang, S.; Han, J.; Wei, X. Targeting Epigenetic Regulators for Cancer Therapy: Mechanisms and Advances in Clinical Trials. Signal Transduct. Target. Ther. 2019 , 4 , 62. [ Google Scholar ] [ CrossRef ]
- Cramer, S.A.; Adjei, I.M.; Labhasetwar, V. Advancements in the Delivery of Epigenetic Drugs. Expert Opin. Drug Deliv. 2015 , 12 , 1501–1512. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Cacabelos, R.; Torrellas, C. Epigenetics of Aging and Alzheimer’s Disease: Implications for Pharmacogenomics and Drug Response. Int. J. Mol. Sci. 2015 , 16 , 30483–30543. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Peedicayil, J. Role of Epigenetics in Pharmacotherapy, Psychotherapy and Nutritional Management of Mental Disorders. J. Clin. Pharm. Ther. 2012 , 37 , 499–501. [ Google Scholar ] [ CrossRef ]
- Kelly, T.K.; Carvalho, D.D.D.; Jones, P.A. Epigenetic Modifications as Therapeutic Targets. Nat. Biotechnol. 2010 , 28 , 1069–1078. [ Google Scholar ] [ CrossRef ]
- Puri, B.K. Calcium Signaling and Gene Expression. In Calcium Signaling ; Islam, M.S., Ed.; Springer International Publishing: Cham, Switzerland, 2020; pp. 537–545. [ Google Scholar ]
- Sharma, S.; Kelly, T.K.; Jones, P.A. Epigenetics in Cancer. Carcinogenesis 2009 , 31 , 27–36. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Gladkova, M.G.; Leidmaa, E.; Anderzhanova, E.A. Epidrugs in the therapy of central nervous system disorders: A way to drive on? Cells 2023 , 12 , 1464. [ Google Scholar ] [ CrossRef ]
- Krishnan, V.; Nestler, E.J. Linking molecules to mood: New insight into the biology of depression. Am. J. Psychiatry 2010 , 167 , 1305–1320. [ Google Scholar ] [ CrossRef ]
- Radosavljevic, M.; Svob Strac, D.; Jancic, J.; Samardzic, J. The role of pharmacogenetics in personalizing the antidepressant and anxiolytic therapy. Genes 2023 , 14 , 1095. [ Google Scholar ] [ CrossRef ]
- Huang, Z.; Jiang, H.; Liu, X.; Chen, Y.; Wong, J.; Wang, Q.; Huang, W.; Shi, T.; Zhang, J. HEMD: An integrated tool of human epigenetic enzymes and chemical modulators for therapeutics. PLoS ONE 2012 , 7 , e39917. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Sales, A.J.; Biojone, C.; Terceti, M.S.; Guimarães, F.S.; Gomes, M.V.M.; Joca, S.R.L. Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors. Br. J. Pharmacol. 2011 , 164 , 1711–1721. [ Google Scholar ] [ CrossRef ]
- Luo, H.; Zhao, Q.; Wei, W.; Zheng, L.; Yi, S.; Li, G.; Wang, W.; Sheng, H.; Pu, H.; Mo, H.; et al. Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer. Sci. Transl. Med. 2020 , 12 , eaax7533. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Nohesara, S.; Abdolmaleky, H.M.; Zhou, J.-R.; Thiagalingam, S. Microbiota-Induced Epigenetic Alterations in Depressive Disorders Are Targets for Nutritional and Probiotic Therapies. Genes 2023 , 14 , 2217. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Nassiri, F.; Chakravarthy, A.; Feng, S.; Shen, S.Y.; Nejad, R.; Zuccato, J.A.; Voisin, M.R.; Patil, V.; Horbinski, C.; Aldape, K.; et al. Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes. Nat. Med. 2020 , 26 , 1044–1047. [ Google Scholar ] [ CrossRef ]
- Yuan, M.; Yang, B.; Rothschild, G.; Mann, J.J.; Sanford, L.D.; Tang, X.; Huang, C.; Wang, C.; Zhang, W. Epigenetic regulation in major depression and other stress-related disorders: Molecular mechanisms, clinical relevance and therapeutic potential. Signal Transduct. Target. Ther. 2023 , 8 , 309. [ Google Scholar ] [ CrossRef ]
- Li, M.; D’Arcy, C.; Li, X.; Zhang, T.; Joober, R.; Meng, X. What do DNA methylation studies tell us about depression? A systematic review. Transl. Psychiatry 2019 , 9 , 68. [ Google Scholar ] [ CrossRef ]
- Duan, Z.; Lu, J. DNA Methyltransferases in Depression: An Update. Front. Psychiatry 2020 , 11 , 538683. [ Google Scholar ] [ CrossRef ]
- Figueroa, M.E.; Abdel-Wahab, O.; Lu, C.; Ward, P.S.; Patel, J.; Shih, A.; Li, Y.; Bhagwat, N.; Vasanthakumar, A.; Fernandez, H.F.; et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010 , 18 , 553–567. [ Google Scholar ] [ CrossRef ]
- Berdasco, M.; Esteller, M. Clinical epigenetics: Seizing opportunities for translation. Nat. Rev. Genet. 2019 , 20 , 109–127. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Scangos, K.W.; State, M.W.; Miller, A.H.; Baker, J.T.; Williams, L.M. New and emerging approaches to treat psychiatric disorders. Nat. Med. 2023 , 29 , 317–333. [ Google Scholar ] [ CrossRef ]
- Jones, P.A.; Issa, J.-P.J.; Baylin, S. Targeting the cancer epigenome for therapy. Nat. Rev. Genet. 2016 , 17 , 630–641. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Morel, D.; Jeffery, D.; Aspeslagh, S.; Almouzni, G.; Postel-Vinay, S. Combining epigenetic drugs with other therapies for solid tumours—Past lessons and future promise. Nat. Rev. Clin. Oncol. 2020 , 17 , 91–107. [ Google Scholar ] [ CrossRef ]
- Topper, M.J.; Vaz, M.; Chiappinelli, K.B.; Shields, C.E.D.; Niknafs, N.; Yen, R.-W.C.; Wenzel, A.; Hicks, J.; Ballew, M.; Stone, M. Epigenetic therapy ties MYC depletion to reversing immune evasion and treating lung cancer. Cell 2017 , 171 , 1284–1300. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Rothstein, M.A.; Cai, Y.; Marchant, G.E. The ghost in our genes: Legal and ethical implications of epigenetics. Health Matrix (Cleveland, Ohio: 1991) 2009 , 19 , 1. [ Google Scholar ]
- The BLUEPRINT consortium. Quantitative comparison of DNA methylation assays for biomarker development and clinical applications. Nat. Biotechnol. 2016 , 34 , 726–737. [ Google Scholar ] [ CrossRef ]
- Yu, X.; Zhao, H.; Wang, R.; Chen, Y.; Ouyang, X.; Li, W.; Sun, Y.; Peng, A. Cancer epigenetics: From laboratory studies and clinical trials to precision medicine. Cell Death Discov. 2024 , 10 , 28. [ Google Scholar ] [ CrossRef ]
- Majchrzak-Celińska, A.; Warych, A.; Szoszkiewicz, M. Novel Approaches to Epigenetic Therapies: From Drug Combinations to Epigenetic Editing. Genes 2021 , 12 , 208. [ Google Scholar ] [ CrossRef ]
- Mabe, N.W.; Perry, J.A.; Malone, C.F.; Stegmaier, K. Pharmacological targeting of the cancer epigenome. Nat. Cancer 2024 , 5 , 844–865. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Nakamura, M.; Gao, Y.; Dominguez, A.A.; Qi, L.S. CRISPR technologies for precise epigenome editing. Nat. Cell Biol. 2021 , 23 , 11–22. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Aljabali, A.A.A.; El-Tanani, M.; Tambuwala, M.M. Principles of CRISPR-Cas9 technology: Advancements in genome editing and emerging trends in drug delivery. J. Drug Deliv. Sci. Technol. 2024 , 92 , 105338. [ Google Scholar ] [ CrossRef ]
- Hong, T.H.; Park, W.-Y. Single-cell genomics technology: Perspectives. Exp. Mol. Med. 2020 , 52 , 1407–1408. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Adil, A.; Kumar, V.; Jan, A.T.; Asger, M. Single-Cell Transcriptomics: Current Methods and Challenges in Data Acquisition and Analysis. Front. Neurosci. 2021 , 15 , 591122. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Huang, D.; Ma, N.; Li, X.; Gou, Y.; Duan, Y.; Liu, B.; Xia, J.; Zhao, X.; Wang, X.; Li, Q.; et al. Advances in single-cell RNA sequencing and its applications in cancer research. J. Hematol. Oncol. 2023 , 16 , 98. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Gammoh, O.; Qnais, E.Y.; Athamneh, R.Y.; Al-Jaidi, B.; Al-Tawalbeh, D.; Altaber, S.; Alqudah, A.; Aljabali, A.A.A.; Tambuwala, M.M. Unraveling the Potential of Isorhamnetin as an Adjuvant in Depression Treatment with Escitalopram. Curr. Issues Mol. Biol. 2023 , 45 , 7668–7679. [ Google Scholar ] [ CrossRef ]
- Vadivalagan, C.; Krishnan, A.; Chen, S.-J.; Hseu, Y.-C.; Muthu, S.; Dhar, R.; Aljabali, A.A.A.; Tambuwala, M.M. The Warburg effect in osteoporosis: Cellular signaling and epigenetic regulation of energy metabolic events to targeting the osteocalcin for phenotypic alteration. Cell. Signal. 2022 , 100 , 110488. [ Google Scholar ] [ CrossRef ]
- Chen, X.; Xu, H.; Shu, X.; Song, C.-X. Mapping epigenetic modifications by sequencing technologies. Cell Death Differ. 2023 . [ Google Scholar ] [ CrossRef ]
- Füllgrabe, J.; Gosal, W.S.; Creed, P.; Liu, S.; Lumby, C.K.; Morley, D.J.; Ost, T.W.B.; Vilella, A.J.; Yu, S.; Bignell, H.; et al. Simultaneous sequencing of genetic and epigenetic bases in DNA. Nat. Biotechnol. 2023 , 41 , 1457–1464. [ Google Scholar ] [ CrossRef ]
- Zhang, Q.; Ma, S.; Liu, Z.; Zhu, B.; Zhou, Z.; Li, G.; Meana, J.J.; González-Maeso, J.; Lu, C. Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes. Nat. Commun. 2023 , 14 , 4672. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Vaisvila, R.; Ponnaluri, V.K.C.; Sun, Z.; Langhorst, B.W.; Saleh, L.; Guan, S.; Dai, N.; Campbell, M.A.; Sexton, B.S.; Marks, K.; et al. Enzymatic methyl sequencing detects DNA methylation at single-base resolution from picograms of DNA. Genome Res. 2021 , 31 , 1280–1289. [ Google Scholar ] [ CrossRef ]
- Wu, Y.-L.; Lin, Z.-J.; Li, C.-C.; Lin, X.; Shan, S.-K.; Guo, B.; Zheng, M.-H.; Li, F.; Yuan, L.-Q.; Li, Z.-h. Epigenetic regulation in metabolic diseases: Mechanisms and advances in clinical study. Signal Transduct. Target. Ther. 2023 , 8 , 98. [ Google Scholar ] [ CrossRef ] [ PubMed ]
- Farsetti, A.; Illi, B.; Gaetano, C. How epigenetics impacts on human diseases. Eur. J. Intern. Med. 2023 , 114 , 15–22. [ Google Scholar ] [ CrossRef ] [ PubMed ]
Click here to enlarge figure
Epigenetic Mechanisms (EM) | Relationship to Depression | Relevant Studies |
---|
| Altered DNA methylation patterns in genes associated with neurodevelopment and neurotransmission have been linked to depression susceptibility and treatment response. | - Investigation of DNA methylation in the serotonin transporter gene (SLC6A4) and its association with depression risk and MDD and antidepressant response. The focus appears to be on understanding the relationships between MDD, childhood trauma, and biological factors such as DNA methylation and hippocampal volume [ ]. - Study on DNA methylation changes in brain-derived neurotrophic factor (BDNF) and their role in depression pathophysiology [ ]. - Genome-wide DNA methylation profiling in MDD, identifying epigenetic biomarkers and biological pathways involved in the disorder. Methylation levels of 14 DMRs in genes predisposing toward major depressive disorder were positively associated with depression scores, giving a possible mechanism for how methylation affects depression. Genes of interest were the following: BMP2, PRDM7, KCNIP1, GRIK2, TPRN2, GATA2, HELZ2, and ZNF624 [ , ]. |
| Dysregulation of histone-modifying enzymes has been observed in depression, affecting genes involved in synaptic plasticity and stress response. | - The role of circadian genes and histone modifications in MDD such as those affecting sleep, temperature, hormonal secretions, and mood are associated with MDD and antidepressant treatment [ ]. - Investigation of chromatin modifications and their impact on cognitive behaviors in depression [ ]. - Epigenetic regulation of genes implicated in synaptic function and neuronal plasticity in MDD [ ]. |
| Dysregulation of miRNAs has been associated with neuroinflammation, synaptic plasticity, and stress response pathways, making them potential diagnostic biomarkers and therapeutic targets for depression. | - MicroRNAs in MDD, depression, and suicide disorder [ ]. - Altered miRNA expression in peripheral blood mononuclear cells in depression patients, revealing potential circulating biomarkers [ ]. |
| Aberrant expression of lncRNAs has been implicated in depression, modulating gene expression and affecting key pathways in the brain. | - Comprehensive profiling of lncRNA expression in postmortem brain tissues of depression patients, revealing potential therapeutic targets [ , ]. - Meta-analysis of lncRNA expression patterns in blood samples of patients with MDD [ ]. |
| Altered chromatin remodeling complexes have been associated with depression, influencing the accessibility of genes involved in neuroplasticity and stress response. | - The roles of histone acetylation, DNA methylation, and non-coding RNA. Behavioral response to stress, depressive behaviors, and response to antidepressants [ ]. - Chromatin medication and their cognitive behaviors in depression [ ]. - Identification of altered chromatin accessibility in MDD patient-derived neurons, providing insights into the transcriptional dysregulation by studying open and closed chromatin states in the brain, with emphasis on neuropsychiatric disorders [ ]. - Altered chromatin accessibility in MDD patient-derived neurons [ ] |
| Changes in DNA hydroxy methylation have been observed in depression, potentially influencing gene expression and neurodevelopmental processes. | - Investigation of DNA hydroxy methylation dynamics in depression using postmortem brain tissues [ ]. - Altered DNA hydroxy methylation patterns in peripheral blood samples of depression patients [ ]. - The role of DNA hydroxy methylation in depression susceptibility and treatment response [ ]. |
| Dysregulation of RNA editing enzymes has been implicated in depression, leading to altered transcriptomes and neurobiological processes. | - RNA editing landscape in MDD patient brains, highlighting potential editing sites in genes relevant to depression [ ]. - Study on the impact of RNA editing adenosine to inosine (A-to-I) RNA editing and m6A methylations on MDD [ ]. - Altered RNA editing profiles in peripheral blood samples of patients with treatment-resistant depression and bipolar disorder. The association of RNA editing variant modifications with depression subtypes [ ]. |
| Changes in chromosomal conformation have been associated with depression, affecting gene interactions and regulatory networks in the brain. | - Hi-C analysis of chromosomal interactions in MDD, dysthymic disorder, and depression in bipolar disorder patient brain tissues, identifying altered 3D chromatin organization [ ]. - Investigation of chromosomal interactions and their role in gene regulation in a mouse model of depression [ ]. - Altered chromosomal conformation associated with genes involved in synaptic function and depressive behaviors in MDD [ ]. |
| Epigenetic changes in parental germ cells have been implicated in the risk of depression in offspring, suggesting transgenerational epigenetic inheritance. | - Investigation of transgenerational effects of stress-induced DNA methylation changes on chronic stress susceptibility in rat offspring [ ]. - Human study exploring the potential impact of parental early life stress on DNA methylation patterns in MDD, dysthymic disorder, and depression in bipolar disorder patients and their children [ , ]. - Evidence for transgenerational epigenetic inheritance in depression and its underlying depression mechanisms [ ]. |
| The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
Share and Cite
Aljabali, A.A.A.; Alkaraki, A.K.; Gammoh, O.; Tambuwala, M.M.; Mishra, V.; Mishra, Y.; Hassan, S.S.; El-Tanani, M. Deciphering Depression: Epigenetic Mechanisms and Treatment Strategies. Biology 2024 , 13 , 638. https://doi.org/10.3390/biology13080638
Aljabali AAA, Alkaraki AK, Gammoh O, Tambuwala MM, Mishra V, Mishra Y, Hassan SS, El-Tanani M. Deciphering Depression: Epigenetic Mechanisms and Treatment Strategies. Biology . 2024; 13(8):638. https://doi.org/10.3390/biology13080638
Aljabali, Alaa A. A., Almuthanna K. Alkaraki, Omar Gammoh, Murtaza M. Tambuwala, Vijay Mishra, Yachana Mishra, Sk. Sarif Hassan, and Mohamed El-Tanani. 2024. "Deciphering Depression: Epigenetic Mechanisms and Treatment Strategies" Biology 13, no. 8: 638. https://doi.org/10.3390/biology13080638
Article Metrics
Article access statistics, further information, mdpi initiatives, follow mdpi.
Subscribe to receive issue release notifications and newsletters from MDPI journals
IMAGES
COMMENTS
High scoring IB Biology Extended Essay examples. See what past students did and make your Biology EE perfect by learning from examiner commented examples!
Learn how to write a successful Extended Essay for the IB Diploma Programme, a mini-thesis that counts toward your diploma. Find out how to choose a topic, pick an advisor, conduct research, and get an A grade.
From the IB: papers from other students and how they scored. Renaissance Library Past Essays : Links to all subject area examples.
Find out how IB Diploma Programme students choose and write about diverse topics for their extended essays. See examples of essay titles and access guidance and resources from the IB programme resource centre.
Biology EE Topics | 40 Ideas for a biology Extended Essay (EE) in the International Baccalaureate (IB) program.
Learn about the extended essay, a mandatory component of the IB Diploma Programme, and read a subject brief with an outline of the course. Find examples of extended essay titles from previous DP students and access DP subject briefs for each subject.
Samples from the IBO The IBO publishes two volumes of 50 Excellent Extended Essays, covering all Diploma Programme groups -- and all scored a top A grade.
Learn how to choose, research, and write a Biology Extended Essay for IB. Find out the differences between Biology EE and Internal Assessment, and get tips on structure, analysis, and evaluation.
Learn how to write a 4,000-word research paper for the International Baccalaureate® Diploma Programme core. Find resources on research question, data collection, analysis, argumentation, and more for Biology extended essay.
Excellent Extended Essays - Biology. Are commercial methods of oral rinse (mouthwash) more effective than the traditional methods of oral hygiene (tea, sesame oil, baking soda, myrrh) in preventing the growth of Micrococcus luteus? (2012) A study on the effect of Indole acetic acid, a growth hormone, on the growth of crop plants, rice (Oryza ...
Decide on a subject in which to write the essay Check the list of available subjects here Read the IB's criteria for your subject Read an exemplar essay in your subject Decide on a topic within this subject Explore some possible research questions relating to this topic This means you will need to do some research! Discuss these with your advisor During the first meeting with your advisor ...
The topic must relates specifically to biology. Many topics can be approached from different viewpoints, but for an EE in biology the treatment of the topic must be clearly biological. For example, an EE in an interdisciplinary area such as biochemistry will, if registered under the subject of biology, be judged solely on its biological content.
High scoring IB Extended Essay examples for all subjects. See what past students did and make your EE perfect by learning from examiner commented examples!
The International Baccalaureate® (IB) provides several resources for IB World Schools. These include support materials for the extended essay. Items in the IB store are available to everyone. Publications include: 50 more extended essays, a DVD of essays submitted in the DP that all fulfil the requirements for an 'A' grade in the current ...
IB Diploma Program Extended Essay Research Guide Class of 2025 - Sample Extended Esssays
Well, it was quite daunting a time for me, BUT—I have to admit that I learned a lot from messing up my project. Looking back, the nine months I spent on my EE was indeed an endurance experience. Here are my takeaways from almost failing my Biology EE. Some of them might be relevant to other EE subjects, but they mainly revolve around the ...
EE Examples Elevate your Extended Essay game for free! Get access to our unbeatable collection of Free EE Examples and score big on your IB exams.
Extended essay This session there was, as expected, a greater than normal share of theoretical essays (based on secondary data), or in some cases essays based on some minimal lab work supplemented by an analysis and evaluation of secondary data.
Biology Example PPF. PDF forms are not compatible with the Google Chrome PDF viewer plug-in. Chrome users should save the form. then reopen and complete with Adobe reader EE/RPPF For use from May/November 2018 page 1 / 3 Candidate personal code International Baccalaureate Baccalauréat International Bachillerato Internacional Extended essay ...
Here are 100 of the examples of the best EE titles out there! Find inspiration for your 4,000 word extended essay topic across a variety of subjects.
An extended essay in biology provides you with the opportunity to apply a range of skills while researching a topic of personal interest in the field of biology.
High scoring IB World Studies Extended Essay examples. See what past students did and make your World Studies EE perfect by learning from examiner commented examples!
CONTEXT: Every year, at least one Biology essay is very accessible, usually both are. This resource is to practise and revise for the accessible essay(s). It makes the preparation SPECIFIC, and EASY. Included is + key revision of the 14 common topic areas (AO1) to learn. + written importance examples (AO2) to learn, from the 14 common topics.
Depression, a significant mental health disorder, is under intense research scrutiny to uncover its molecular foundations. Epigenetics, which focuses on controlling gene expression without altering DNA sequences, offers promising avenues for innovative treatment. This review explores the pivotal role of epigenetics in depression, emphasizing two key aspects: (I) identifying epigenetic targets ...