The Soil's Secrets: A Microbial 'Stress Vaccine' Revolutionizing Mental Health
Hygiene hypothesis and treatments for Type I reactions
From the Hygiene Hypothesis to Bacterial Dysbiosis
COMMENTS
The hygiene hypothesis: current perspectives and future therapies
The old friends hypothesis, proposed by Rook et al, notes the co-evolution of microorganisms and macroorganisms, such as parasitic helminths, with the development of the human immune system. 22 Similar to the hygiene hypothesis, it suggests that these organisms are required for normal immune system development. 22, 24 For example, a study in ...
Is the Hygiene Hypothesis True?
The hygiene hypothesis is the idea that kids need to be exposed to germs in order to develop healthy immune systems. We know that many common viruses did not circulate as widely during the pandemic, thanks to social distancing, masking, and other COVID mitigation measures. Are there downsides to those missed infections? In this Q&A, Caitlin ...
The Hygiene Hypothesis and New Perspectives—Current Challenges Meeting
Keywords: hygiene hypothesis, allergy, asthma, non-communicable inflammatory diseases, chronic inflammation. Go to: Throughout its history, the Hygiene Hypothesis has shown itself to be adaptable and flexible whenever it has been challenged by innovation in science ( 1 ). A number of new findings need to be considered in this ongoing revisiting ...
The Hygiene Hypothesis
The Hygiene Hypothesis and the Bacterial World. Even before high-throughput sequencing techniques were established that allow a deeper view into the microbial world on our body surfaces, Noverr and Hufnagle proclaimed the "Microbiota Hypothesis" by which they claimed the microbiota to be indispensable for developing and maintaining a tolerogenic immune status ().
Full article: The hygiene hypothesis: current perspectives and future
The "hygiene hypothesis", proposed by Strachan in 1989, aimed to explain this peculiar generational rise in immune dysregulation. However, research over the past 10 years provides evidence connecting the commensal and symbiotic microbes (intestinal microbiota) and parasitic helminths with immune development, expanding the hygiene hypothesis ...
Frontiers
The Hygiene Hypothesis and New Perspectives—Current Challenges Meeting an Old Postulate. Holger Garn 1,2* Daniel Piotr Potaczek 1 Petra Ina Pfefferle 2,3,4. 1 Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Medical Faculty, Biochemical Pharmacological Center (BPC), Philipps University of Marburg ...
The hygiene hypothesis, the COVID pandemic, and consequences for the
The model in Fig. 1 outlines the process by which microbial diversity is lost. Gut microbial richness results from a balance of the acquisition and the loss of microbial species. The original hygiene hypothesis, first framed by David Strachan (), has evolved into new, more complex and explicit hypotheses that capture many of the processes that influence gut microbial establishment and ...
The hygiene hypothesis at a glance: Early exposures, immune mechanism
The hygiene hypothesis was proposed almost three decades ago. Nevertheless, its mechanism still remains with relevant controversies. Some studies defend that early exposures during childhood to microbes and parasites are key determinants to prevent allergies and autoimmune diseases; however, other studies demonstrated that these early exposures can even potentiate the clinical scenario of the ...
The hygiene hypothesis in autoimmunity: the role of pathogens and
The initial application of the hygiene hypothesis for autoimmune diseases proposed in the early 2000s has been confirmed and consolidated by a wealth of published data in both animal models and ...
The germless theory of allergic disease: revisiting the hygiene hypothesis
As with most recent speculation about the hygiene hypothesis, parasitic studies have mainly been discussed in the context of the T-helper-type 1/2 (T H 1/T H 2) model of functional subsets of CD4 ...
Cleaning up the hygiene hypothesis
They decided the name has to go ( 15 ). "The trouble is, as soon as you use the words 'hygiene hypothesis,' the word hygiene prejudges what the cause is," says Bloomfield. To the public, "hygiene" is interpreted as personal cleanliness: washing hands, keeping food clean and fresh, sanitizing the home.
The Hygiene Hypothesis
The epidemiological basis for the Hygiene Hypothesis became apparent long before the Hygiene Hypothesis was postulated. Two simple observations were made in the 1960s and in the 1970s. First, a Swedish study described differences in the prevalence of asthma and socio-medical conditions between populations living in urban or rural sites ( 2 ).
The Effect of Infections on Susceptibility to Autoimmune and Allergic
The hygiene hypothesis postulates that an environment with a high incidence of infectious diseases protects against allergic and autoimmune diseases, whereas hygienic surroundings increase the inci...
Editorial: The Immunological Implications of the Hygiene Hypothesis
While the Hygiene Hypothesis was originally established in the context of allergic diseases, Jean-Francois Bach expanded its application to other conditions such as autoimmune diseases in the early 2000s . In this Research Topic, he contributes a sophisticated review article revisiting the Hygiene Hypothesis in the context of autoimmune ...
Hygiene Hypothesis
For many years already, the hygiene hypothesis has been called an outdated concept; various times it was revised and transformed, and finally it gave birth to novel hypotheses. Anyway, the hygiene hypothesis has promoted radical rethinking of infections, microbiota, and coevolution of mankind and microbes (Dethlefsen et al., 2007). With the ...
Hygiene hypothesis
Hygiene hypothesis. In medicine, the hygiene hypothesis states that early childhood exposure to particular microorganisms (such as the gut flora and helminth parasites) protects against allergies by properly tuning the immune system. [1][2] In particular, a lack of such exposure is thought to lead to poor immune tolerance. [1]
The hygiene hypothesis: current perspectives and future therapies
The old friends hypothesis, proposed by Rook et al, notes the co-evolution of microorganisms and macroorganisms, such as parasitic helminths, with the development of the human immune system. 22 Similar to the hygiene hypothesis, it suggests that these organisms are required for normal immune system development. 22,24 For example, a study in ...
The hygiene hypothesis
Moises Velasquez-Manoff. Scribner, 2012 400 pp., hardcover, $29.00 1439199388 | ISBN: 1-439-19938-8. An Epidemic of Absence is a timely account of the hygiene hypothesis, and it delivers a rich ...
Hygiene hypothesis: Fact or fiction?
The hygiene hypothesis of asthma and allergy has recently received a swell of popularity and published supporting evidence, and has been extended to autoimmune conditions of childhood. Broadly stated, naturally occurring infections and microbial exposures might essentially immunize against the development of asthma and allergic and autoimmune diseases. If true, then reductions in nature's ...
'Hygiene hypothesis' connection: cleanliness and immune system
It's not that adherents to the offshoots of the hygiene hypothesis are urging us to live in dirty homes. Rather, it's about striking a reasonable balance between cleanliness and zero tolerance. (Send your questions to [email protected], or write: Ask the Doctors, c/o UCLA Health Sciences Media Relations, 10880 Wilshire Blvd ...
Too clean, or not too clean: the Hygiene Hypothesis and home hygiene
Summary. The 'hygiene hypothesis' as originally formulated by Strachan, proposes that a cause of the recent rapid rise in atopic disorders could be a lower incidence of infection in early childhood, transmitted by unhygienic contact with older siblings. Use of the term 'hygiene hypothesis' has led to several interpretations, some of ...
What Is the Hygiene Hypothesis?
The hygiene hypothesis says a child's environment can be "too clean," and the lack of exposure to germs does not give the immune system a chance to develop resistance to diseases.(Image credit ...
Determinants of hand hygiene compliance among healthcare workers in
Practicing hand hygiene is a cost-effective method to decrease the occurrence of Healthcare-Associated Infections (HAIs). However, despite their simplicity, adhering to hand hygiene methods among healthcare workers (HCWs) can be highly challenging. We aim to examine the factors influencing hand hygiene compliance as perceived by HCWs working in the intensive care units (ICUs) at several major ...
Got Clean Hands? Help Us Study the Science Behind Hygiene
This two-day study involves two sessions where participants will be trained on a hand hygiene procedure to assess the effectiveness of common hand hygiene agents for the inactivation of viruses on human hands. Upon completion of both sessions, participants will be compensated with a $50 Amazon or Walmart gift card, per their preference. ...
The 'hygiene hypothesis' for autoimmune and allergic diseases: an
The hygiene hypothesis is based upon epidemiological data, particularly migration studies, showing that subjects migrating from a low-incidence to a high-incidence country acquire the immune disorders with a high incidence at the first generation. However, these data and others showing a correlation between high disease incidence and high socio ...
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COMMENTS
The old friends hypothesis, proposed by Rook et al, notes the co-evolution of microorganisms and macroorganisms, such as parasitic helminths, with the development of the human immune system. 22 Similar to the hygiene hypothesis, it suggests that these organisms are required for normal immune system development. 22, 24 For example, a study in ...
The hygiene hypothesis is the idea that kids need to be exposed to germs in order to develop healthy immune systems. We know that many common viruses did not circulate as widely during the pandemic, thanks to social distancing, masking, and other COVID mitigation measures. Are there downsides to those missed infections? In this Q&A, Caitlin ...
Keywords: hygiene hypothesis, allergy, asthma, non-communicable inflammatory diseases, chronic inflammation. Go to: Throughout its history, the Hygiene Hypothesis has shown itself to be adaptable and flexible whenever it has been challenged by innovation in science ( 1 ). A number of new findings need to be considered in this ongoing revisiting ...
The Hygiene Hypothesis and the Bacterial World. Even before high-throughput sequencing techniques were established that allow a deeper view into the microbial world on our body surfaces, Noverr and Hufnagle proclaimed the "Microbiota Hypothesis" by which they claimed the microbiota to be indispensable for developing and maintaining a tolerogenic immune status ().
The "hygiene hypothesis", proposed by Strachan in 1989, aimed to explain this peculiar generational rise in immune dysregulation. However, research over the past 10 years provides evidence connecting the commensal and symbiotic microbes (intestinal microbiota) and parasitic helminths with immune development, expanding the hygiene hypothesis ...
The Hygiene Hypothesis and New Perspectives—Current Challenges Meeting an Old Postulate. Holger Garn 1,2* Daniel Piotr Potaczek 1 Petra Ina Pfefferle 2,3,4. 1 Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Medical Faculty, Biochemical Pharmacological Center (BPC), Philipps University of Marburg ...
The model in Fig. 1 outlines the process by which microbial diversity is lost. Gut microbial richness results from a balance of the acquisition and the loss of microbial species. The original hygiene hypothesis, first framed by David Strachan (), has evolved into new, more complex and explicit hypotheses that capture many of the processes that influence gut microbial establishment and ...
The hygiene hypothesis was proposed almost three decades ago. Nevertheless, its mechanism still remains with relevant controversies. Some studies defend that early exposures during childhood to microbes and parasites are key determinants to prevent allergies and autoimmune diseases; however, other studies demonstrated that these early exposures can even potentiate the clinical scenario of the ...
The initial application of the hygiene hypothesis for autoimmune diseases proposed in the early 2000s has been confirmed and consolidated by a wealth of published data in both animal models and ...
As with most recent speculation about the hygiene hypothesis, parasitic studies have mainly been discussed in the context of the T-helper-type 1/2 (T H 1/T H 2) model of functional subsets of CD4 ...
They decided the name has to go ( 15 ). "The trouble is, as soon as you use the words 'hygiene hypothesis,' the word hygiene prejudges what the cause is," says Bloomfield. To the public, "hygiene" is interpreted as personal cleanliness: washing hands, keeping food clean and fresh, sanitizing the home.
The epidemiological basis for the Hygiene Hypothesis became apparent long before the Hygiene Hypothesis was postulated. Two simple observations were made in the 1960s and in the 1970s. First, a Swedish study described differences in the prevalence of asthma and socio-medical conditions between populations living in urban or rural sites ( 2 ).
The hygiene hypothesis postulates that an environment with a high incidence of infectious diseases protects against allergic and autoimmune diseases, whereas hygienic surroundings increase the inci...
While the Hygiene Hypothesis was originally established in the context of allergic diseases, Jean-Francois Bach expanded its application to other conditions such as autoimmune diseases in the early 2000s . In this Research Topic, he contributes a sophisticated review article revisiting the Hygiene Hypothesis in the context of autoimmune ...
For many years already, the hygiene hypothesis has been called an outdated concept; various times it was revised and transformed, and finally it gave birth to novel hypotheses. Anyway, the hygiene hypothesis has promoted radical rethinking of infections, microbiota, and coevolution of mankind and microbes (Dethlefsen et al., 2007). With the ...
Hygiene hypothesis. In medicine, the hygiene hypothesis states that early childhood exposure to particular microorganisms (such as the gut flora and helminth parasites) protects against allergies by properly tuning the immune system. [1][2] In particular, a lack of such exposure is thought to lead to poor immune tolerance. [1]
The old friends hypothesis, proposed by Rook et al, notes the co-evolution of microorganisms and macroorganisms, such as parasitic helminths, with the development of the human immune system. 22 Similar to the hygiene hypothesis, it suggests that these organisms are required for normal immune system development. 22,24 For example, a study in ...
Moises Velasquez-Manoff. Scribner, 2012 400 pp., hardcover, $29.00 1439199388 | ISBN: 1-439-19938-8. An Epidemic of Absence is a timely account of the hygiene hypothesis, and it delivers a rich ...
The hygiene hypothesis of asthma and allergy has recently received a swell of popularity and published supporting evidence, and has been extended to autoimmune conditions of childhood. Broadly stated, naturally occurring infections and microbial exposures might essentially immunize against the development of asthma and allergic and autoimmune diseases. If true, then reductions in nature's ...
It's not that adherents to the offshoots of the hygiene hypothesis are urging us to live in dirty homes. Rather, it's about striking a reasonable balance between cleanliness and zero tolerance. (Send your questions to [email protected], or write: Ask the Doctors, c/o UCLA Health Sciences Media Relations, 10880 Wilshire Blvd ...
Summary. The 'hygiene hypothesis' as originally formulated by Strachan, proposes that a cause of the recent rapid rise in atopic disorders could be a lower incidence of infection in early childhood, transmitted by unhygienic contact with older siblings. Use of the term 'hygiene hypothesis' has led to several interpretations, some of ...
The hygiene hypothesis says a child's environment can be "too clean," and the lack of exposure to germs does not give the immune system a chance to develop resistance to diseases.(Image credit ...
Practicing hand hygiene is a cost-effective method to decrease the occurrence of Healthcare-Associated Infections (HAIs). However, despite their simplicity, adhering to hand hygiene methods among healthcare workers (HCWs) can be highly challenging. We aim to examine the factors influencing hand hygiene compliance as perceived by HCWs working in the intensive care units (ICUs) at several major ...
This two-day study involves two sessions where participants will be trained on a hand hygiene procedure to assess the effectiveness of common hand hygiene agents for the inactivation of viruses on human hands. Upon completion of both sessions, participants will be compensated with a $50 Amazon or Walmart gift card, per their preference. ...
The hygiene hypothesis is based upon epidemiological data, particularly migration studies, showing that subjects migrating from a low-incidence to a high-incidence country acquire the immune disorders with a high incidence at the first generation. However, these data and others showing a correlation between high disease incidence and high socio ...