epilepsy research paper introduction

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• Published: 03 May 2018
• Orrin Devinsky 1 ,
• Annamaria Vezzani 2 ,
• Terence J. O'Brien 3 , 4 , 5 ,
• Nathalie Jette 6 ,
• Ingrid E. Scheffer 7 , 8 , 9 ,
• Marco de Curtis 10 &
• Piero Perucca 3 , 4 , 5  

Nature Reviews Disease Primers volume  4 , Article number:  18024 ( 2018 ) Cite this article

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• Therapeutics

Epilepsy affects all age groups and is one of the most common and most disabling neurological disorders. The accurate diagnosis of seizures is essential as some patients will be misdiagnosed with epilepsy, whereas others will receive an incorrect diagnosis. Indeed, errors in diagnosis are common, and many patients fail to receive the correct treatment, which often has severe consequences. Although many patients have seizure control using a single medication, others require multiple medications, resective surgery, neuromodulation devices or dietary therapies. In addition, one-third of patients will continue to have uncontrolled seizures. Epilepsy can substantially impair quality of life owing to seizures, comorbid mood and psychiatric disorders, cognitive deficits and adverse effects of medications. In addition, seizures can be fatal owing to direct effects on autonomic and arousal functions or owing to indirect effects such as drowning and other accidents. Deciphering the pathophysiology of epilepsy has advanced the understanding of the cellular and molecular events initiated by pathogenetic insults that transform normal circuits into epileptic circuits (epileptogenesis) and the mechanisms that generate seizures (ictogenesis). The discovery of >500 genes associated with epilepsy has led to new animal models, more precise diagnoses and, in some cases, targeted therapies.

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Departments of Neurology, Neuroscience, Neurosurgery and Psychiatry, NYU School of Medicine, New York, NY, USA

Orrin Devinsky

Department of Neuroscience, Laboratory of Experimental Neurology, IRCCS ‘Mario Negri’ Institute for Pharmacological Research, Milan, Italy

Annamaria Vezzani

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia

Terence J. O'Brien & Piero Perucca

Department of Neurology, Alfred Health, Melbourne, Victoria, Australia

Departments of Neurology and Medicine, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, Victoria, Australia

Department of Neurology and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Nathalie Jette

Department of Medicine, Epilepsy Research Centre, Austin Health, The University of Melbourne, Melbourne, Victoria, Australia

Ingrid E. Scheffer

The Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia

Department of Paediatrics, and Department of Neurology, The University of Melbourne, The Royal Children's Hospital, Melbourne, Victoria, Australia

Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

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Introduction (O.D. and I.E.S.); Epidemiology (N.J.); Mechanisms/pathophysiology (A.V., M.d.C. and I.E.S.); Diagnosis, screening and prevention (P.P. and I.E.S.); Management (T.J.O.B.); Quality of life (O.D.); Outlook (I.E.S. and O.D.); and Overview of Primer (O.D.).

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O.D. has received research funding from the US NIH, GW Pharmaceuticals, Novartis and PTC Pharmaceuticals. He has equity in Egg Rock Holdings, Empatica, Engage Therapeutics, Pairnomix, Rettco and Tilray. He is the Principal Investigator for the North American SUDEP Registry and the SUDC Registry and Research Collaborative. He currently receives research funding from NIH and the US Centers for Disease Control and Prevention. He consults for the Center for Discovery. A.V. has received consultancy fees from UCB Pharma and research grants from Ovid, Pfizer and Takeda. T.J.O.B. has received research funding from Eisai, the National Health and Medical Research Council of Australia, the NIH, the Royal Melbourne Hospital Neuroscience Foundation and UCB Pharma. N.J. currently receives research funding from Alberta Health, the Canadian Institute of Health Research and the NIH, and is an associate editor of Epilepsia and serves on the editorial board of Neurology . I.E.S. has served on scientific advisory boards for BioMarin, Eisai, GlaxoSmithKline, Nutricia and UCB Pharma, sits on the editorial boards of Epileptic Disorders and Neurology and might accrue future revenue on a pending patent. I.E.S. has also received speaker honoraria from Athena Diagnostics, Eisai, GlaxoSmithKline, Transgenomics and UCB Pharma, has received funding for travel from Athena Diagnostics, Biocodex, BioMarin, Eisai, GlaxoSmithKline and UCB Pharma, and has received research support from the American Epilepsy Society, the Australian Research Council, CURE, the Health Research Council of New Zealand, the March of Dimes, the National Health and Medical Research Council of Australia, the NIH, the US Department of Defense Autism Spectrum Disorder Research Program, and Perpetual Charitable Trustees. P.P. has received honoraria from Eisai. All other authors declare no competing interests.

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Supplementary box 1.

Epilepsy syndromes by age of seizure onset. (PDF 88 kb)

Supplementary Table 1

Precision therapies. (PDF 124 kb)

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Devinsky, O., Vezzani, A., O'Brien, T. et al. Epilepsy. Nat Rev Dis Primers 4 , 18024 (2018). https://doi.org/10.1038/nrdp.2018.24

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Schisandrin b, a dual positive allosteric modulator of gabaa and glycine receptors, alleviates seizures in multiple mouse models.

Acta Pharmacologica Sinica (2024)

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State of the art and challenges in epilepsy—a narrative review.

1. Introduction

2. definition and terminology.

• At least two unprovoked (or reflex) seizures occurring more than 24 h apart;
• An unprovoked (or reflex) seizure and the likelihood of subsequent seizures similar to the overall risk of recurrence (at least 60%—accompanied by clinical, electrical-electroencephalogram (EEG), or neuroimaging changes) after two unprovoked seizures occurring within the next 10 years;
• Diagnosis of epilepsy syndrome [ 5 ].

3. Etiology

4. clinical aspects, 5. diagnostic of epilepsy, 6. evolution, complication, and prognostic, 7. healthcare of people with epilepsy.

• Wear a helmet when cycling or horseback riding;
• No unsupervised swimming;
• It is advisable to use the shower, not the bathtub;
• Water temperature control of the hot water heater to reduce the risk of scalding;
• Use a microwave oven, not a stove;
• Avoid locking the toilet or bedroom door;
• The height of the bed should be small in order to avoid possible post-crash injuries;
• It is preferable to use an epilepsy safety pillow (made to reduce the risk of suffocation if sitting face down);
• Be careful of high stairs;
• Beware of driving rules for patients with epilepsy;
• Administration of medication according to the scheme-continuum.

8. Treatment of Epilepsy—Principles of the Current Status

• Epilepsy characteristics: seizure type, seizure frequency, specific epilepsy syndrome;
• Patient characteristics: gender, age, comorbidities, pregnancy, allergies, current and previous medication;
• Drug characteristics: efficacy, adverse reactions, drug interactions, half-life, titration, risk of teratogenicity, interaction with oral contraceptives, liquid/solid form;
• Socio-economic characteristics: cost, availability, personal choice.

9. Drug-Resistant Epilepsy

• Mesial temporal lobe epilepsy or neocortical epilepsy;
• Lesional epilepsy due to focal structural pathology (low-grade glioma, cavernous malformation);
• Nonlesional focal epilepsy.

10. Conclusions

Author contributions, institutional review board statement, informed consent statement, data availability statement, conflicts of interest.

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Share and Cite

Manole, A.M.; Sirbu, C.A.; Mititelu, M.R.; Vasiliu, O.; Lorusso, L.; Sirbu, O.M.; Ionita Radu, F. State of the Art and Challenges in Epilepsy—A Narrative Review. J. Pers. Med. 2023 , 13 , 623. https://doi.org/10.3390/jpm13040623

Manole AM, Sirbu CA, Mititelu MR, Vasiliu O, Lorusso L, Sirbu OM, Ionita Radu F. State of the Art and Challenges in Epilepsy—A Narrative Review. Journal of Personalized Medicine . 2023; 13(4):623. https://doi.org/10.3390/jpm13040623

Manole, Aida Mihaela, Carmen Adella Sirbu, Mihaela Raluca Mititelu, Octavian Vasiliu, Lorenzo Lorusso, Octavian Mihai Sirbu, and Florentina Ionita Radu. 2023. "State of the Art and Challenges in Epilepsy—A Narrative Review" Journal of Personalized Medicine 13, no. 4: 623. https://doi.org/10.3390/jpm13040623

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Table of Contents | June, 2024  Vol. 14  No.1 | Next Issue | Review Original Articles Case Reports --> !--> To submit a manuscript, please visit the e-submission management system at , read the , and log into the e-submission system. For assistance with manuscript submission, please contact: . Anyone may access any past or current articles without logging in. KCC Parktown 101-308, Mallijae-ro 185, Jung-Gu, Seoul, Korea TEL : +82-362-9662   FAX : +82-2-362-9663   E-mail : Copyright© Korean Epilepsy Society.               |   |   |  An official website of the United States government The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Publications Account settings My Bibliography Collections Citation manager Save citation to file Email citation, add to collections. Create a new collection Add to an existing collection Add to My Bibliography Your saved search, create a file for external citation management software, your rss feed. Search in PubMed Search in NLM Catalog Add to Search The inside experience of epilepsy: An essay about the importance of subjectivity Affiliation. 1 Danish Epilepsy Centre Filadelfia, Dianalund, Denmark; Programa de Pós-Graduação em Ciências Médicas, Universidad Federal de Santa Catarina, Florianópolis, SC, Brazil. Electronic address: [email protected]. PMID: 33531199 DOI: 10.1016/j.seizure.2021.01.006 This essay addresses three aspects of the inside experience of epilepsy, i) the high semiological significance of subjective seizure symptoms, ii) the therapeutic consequences, both positive and negative, of subjective seizure experiences, and iii) the importance of recognizing the patient as the 'inside expert' of epilepsy. Subjective symptoms are often not spontaneously reported but ignoring them may be associated with serious risks. They can be experienced as neutral, negative or positive, and this can have important consequences for therapy. Only patients have full and first-hand knowledge of subjective symptoms but an understanding of these symptoms and an adequate response to them requires expert assistance. The inside and outside views of seizures are different but of equal importance. To get the full picture, both are needed to supplement each other. Keywords: Epilepsy surgery; Isolated aura; Patient-doctor relation; Psychoeducation; Seizure arrest; Seizure semiology. Copyright © 2021 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. PubMed Disclaimer Similar articles The importance of semiological information based on epileptic seizure history. Wolf P, Benbadis S, Dimova PS, Vinayan KP, Michaelis R, Reuber M, Yacubian EM. Wolf P, et al. Epileptic Disord. 2020 Feb 1;22(1):15-31. doi: 10.1684/epd.2020.1137. Epileptic Disord. 2020. PMID: 32096471 Review. The promises and pitfalls of seizure phenomenology. Wardrope A. Wardrope A. Seizure. 2023 Dec;113:48-53. doi: 10.1016/j.seizure.2023.11.008. Epub 2023 Nov 11. Seizure. 2023. PMID: 37976801 Review. Semiological seizure classification: before and after video-EEG monitoring of seizures. Hirfanoglu T, Serdaroglu A, Cansu A, Bilir E, Gucuyener K. Hirfanoglu T, et al. Pediatr Neurol. 2007 Apr;36(4):231-5. doi: 10.1016/j.pediatrneurol.2006.12.002. Pediatr Neurol. 2007. PMID: 17437905 Time to response and patient visibility during tonic-clonic seizures in the epilepsy monitoring unit. Malloy K, Cardenas D, Blackburn A, Whitmire L, Cavazos JE. Malloy K, et al. Epilepsy Behav. 2018 Dec;89:84-88. doi: 10.1016/j.yebeh.2018.09.012. Epub 2018 Oct 31. Epilepsy Behav. 2018. PMID: 30388666 Preoperative sensory aura predicts risk for seizure in temporal lobe epilepsy surgery. Arifin MT, Hanaya R, Bakhtiar Y, Bintoro AC, Iida K, Kurisu K, Arita K, Bunyamin J, Askoro R, Brillantika SP, Muttaqin Z. Arifin MT, et al. Epilepsy Behav. 2020 Oct;111:107255. doi: 10.1016/j.yebeh.2020.107255. Epub 2020 Jul 24. Epilepsy Behav. 2020. PMID: 32759061 Search in MeSH Related information Linkout - more resources, full text sources. 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Government issued or sponsored reports contain an additional characteristic - they may be subject to distribution restrictions linked to their classification status. Although references to classified reports may be found in technical reports literature, the security status or limited distribution of reports may make them unavailable to the general public and to the Library as well, as the Library holds only titles in the public domain. Those interested in locating such materials can consult the U.S. Department of Justice's Freedom of Information Act  site for guidance in obtaining these reports. To enable them to be identified and located, technical reports are assigned report codes by agencies or organizations involved in their production or distribution. These codes may be referred to as "accession numbers," "agency report series numbers," "contract numbers," "grant numbers" or by other names, and include dates and individual report numbers. Typically, reports are assigned multiple codes and these codes help to identify the sponsoring agency, the organization performing the research or the organization disseminating the report.  Most technical reports held by the Library of Congress are not cataloged, and, for these reports, one or more report codes is required for Library staff to check the collections for a report or to locate and retrieve it. For more information about the current Standard Technical Report Number format (STRN) see ANSI/NISO Z39.23- 1997 (S2015) Standard Technical Reports Number Format and Creation .  Standards are specifications which define products, methods, processes or practices, and are known to have existed as early as 7000 B.C., when cylindrical stones were used as units of weight in Egypt. According to  Office of Management and Budget (OMB) Circular A-119 , as revised in 2016, the term "standard" or "technical standard" refers to: common and repeated use of rules, conditions, guidelines or characteristics for products or related processes and production methods, and related management systems practices; the definition of terms; classification of components; delineation of procedures; specification of dimensions, materials, performance, designs, or operations; measurement of quality and quantity in describing materials, processes, products, systems, services, or practices; test methods and sampling procedures; or descriptions of fit and measurements of size or strength; and terminology, symbols, packaging, marking or labeling requirements as they apply to a product, process, or production method. Technical standards are not "professional standards of personal conduct; or institutional codes of ethics." (p. 15). Standards are typically generated by governments or by professional associations and organizations interested in or affected by the subject matter of particular standards. For example, U.S. government standards mandated by the  Fair Packaging & Labeling Act (FPLA)  have standardized the labeling required for packaging in which consumer commodities is sold. Standards set the basis for determining consistent and acceptable minimum levels of reliability and safety, and are adhered to either voluntarily or as mandated by law. For a more complete overview, see the NIST report  " The ABC's of Standards Activities " by Maureen A. Breitenberg (2009). The Library of Congress standards collection includes military and other federal standards, industry standards, and a few older international standards from Russia, China, and South Africa. Material from the collection is available in various formats, including digital, print, and microform materials. The majority of the Library's standards collection held in the Science Section's Technical Reports and Standards Collection. The collection remains largely uncatalogued, and as a result, most items from this collection are not discoverable in the Library's online catalog. Inquires on Library holdings can be sent to the Science Section using the Science and Technical Reports Ask-a-Librarian form . Some standards, however, are housed in the Library's general collections and discoverable by searching the  online catalog -- the ASTM standards are one example. Other standards are in custody of appropriate specialized research centers, such as the Law Library , which maintains  OSHA standards and some building codes. About the Science Section Part of the  Science & Business Reading Room  at the Library of Congress, the Science Section is the starting point for conducting research at the Library of Congress in the subject areas of science, medicine and engineering. Here, reference specialists in specific subject areas of science and engineering  assist patrons in formulating search strategies and gaining access to the information and materials contained in the Library's rich collections of science, medicine, and engineering materials. Next: Technical Reports Collections >> Last Updated: Jul 3, 2024 11:51 AM URL: https://guides.loc.gov/technical-reports Brain Diseases Central Nervous System Diseases Nervous System Nervous System Diseases Neuroanatomy Neuroscience Epilepsy and its Management: A Review January 2012 Journal of PharmaSciTech 1(2):20-26 This person is not on ResearchGate, or hasn't claimed this research yet. 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Sign up Warning: The NCBI web site requires JavaScript to function. more... An official website of the United States government The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Publications Account settings Browse Titles NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. An Introduction to Epilepsy Editors: Edward B Bromfield , MD, José E Cavazos , MD, PhD, and Joseph I Sirven , MD. Affiliations Copyright and Permissions An Introduction to Epilepsy was developed by the Student & Resident Education Subcommittee of the American Epilepsy Society's Education Committee as an educational resource for students and faculty. Collapse All Contributors Acknowledgments I. Introduction II. Neurophysiology of the Cerebral Cortex III. Physiological Basis of the EEG IV. Pathophysiology of Seizures: An Alteration in the Normal Balance of Inhibition and Excitation I. Definitions and Epidemiology II. Evaluation After the First Seizure III. Treatment IV. Non-Drug Treatments of Epilepsy V. Epilepsy Surgery VI. Status Epilepticus VII. Neonatal Seizures VIII. Selected Pediatric Epilepsy Syndromes IX. Managing Pediatric Epilepsy X. Nonepileptic Seizures and Imitators of Epilepsy XI. Pregnancy and Epilepsy XII. Driving and Epilepsy Appendix E: Case Studies II. Mechanisms of AED Activity III. AED Pharmacokinetics IV. Additional Pharmacokinetic and Pharmacodynamic Aspects of AEDs V. Adverse Effects Appendix A: Pediatric Case Study I. Epilepsy Presurgical Evaluation II. Surgical Treatment of Epilepsy III. Vagus Nerve Stimulation as a Treatment for Epileptic Seizures IV. Head Injury, Seizures, and Epilepsy All content of An Introduction to Epilepsy , except where otherwise noted, is licensed under a Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cite this Page Bromfield EB, Cavazos JE, Sirven JI, editors. An Introduction to Epilepsy [Internet]. West Hartford (CT): American Epilepsy Society; 2006. Related information NLM Catalog Related NLM Catalog Entries Similar articles in PubMed Elective introduction to oncology. [J Cancer Educ. 1993] Elective introduction to oncology. Axelrod RS, Lowney K. J Cancer Educ. 1993 Spring; 8(1):31-4. Core competencies for the care of older patients: recommendations of the American Geriatrics Society. The Education Committee Writing Group of the American Geriatrics Society. [Acad Med. 2000] Core competencies for the care of older patients: recommendations of the American Geriatrics Society. 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J Adv Nurs. 2005 Oct; 52(2):211-9. Recent Activity An Introduction to Epilepsy An Introduction to Epilepsy Your browsing activity is empty. Activity recording is turned off. Turn recording back on Connect with NLM National Library of Medicine 8600 Rockville Pike Bethesda, MD 20894 Web Policies FOIA HHS Vulnerability Disclosure Help Accessibility Careers 231 IMAGES Research paper on epilepsy (PDF) Prevalence and Incidence of Epilepsy in Italy Based on a (PDF) Introduction to Epilepsy and Related Brain Disorders Epilepsy Research Paper Epilepsy Research Paper Free Essay Example Understanding Epilepsy Chart Poster Laminated COMMENTS Seizures and Epilepsy: An Overview for Neuroscientists Epilepsy is one of the most common and disabling neurologic conditions, yet we have an incomplete understanding of the detailed pathophysiology and, thus, treatment rationale for much of epilepsy. This article reviews the clinical aspects of seizures and epilepsy with the goal of providing neuroscientists an introduction to aspects that might ... Epilepsy-Definition, Classification, Pathophysiology, and Epidemiology Imprecise definitions, failure to use accepted terminology, or inappropriate use of terminology hamper our ability to study and advance the field of epilepsy. This article begins by discussing the pathophysiology and epidemiology of epilepsy, and then covers the accepted contemporary definitions and classifications of seizures and epilepsies. (PDF) A COMPREHENSIVE REVIEW ON EPILEPSY repercussions. Recently, ILAE stated a n ew. definition of epilepsy for clinical use which can be. considered if any of the following situations. experienced by patients: (a) Minimum occurring of ... Epilepsy: A Clinical Overview The diagnosis and treatment of seizures and epilepsy is a common task of the physician. Approximately 1 in 10 people will have a seizure during their lifetime. Epilepsy is the tendency to have unprovoked seizures. Epilepsy is the fourth most common neurological disorder and affects 1 in 26 people in the United States and 65 million people worldwide. Evaluation of a patient presenting with a ... New Trends and Most Promising Therapeutic Strategies for Epilepsy Introduction. Epilepsy is the enduring predisposition of the brain to generate seizures, a condition that carries neurobiological, cognitive, psychological, and social consequences ().Over 50 million people worldwide are affected by epilepsy and its causes remain partially elusive, leaving physicians, and patients an unclear insight into the etiology of the disease and the best treatment ... Recent advances in epilepsy Abstract. This paper reviews advances in epilepsy in recent years with an emphasis on therapeutics and underlying mechanisms, including status epilepticus, drug and surgical treatments. Lessons from rarer epilepsies regarding the relationship between epilepsy type, mechanisms and choice of antiepileptic drugs (AED) are explored and data ... Epilepsy Introduction. Epilepsy is a ... The cross-validation of animal and human findings adds considerable value to epilepsy research because it contributes to the deeper understanding of the mechanisms ... Epilepsy Research Epilepsy Research provides for publication of high quality articles in both basic and clinical research, with a special emphasis on translational research that ultimately relates to epilepsy as a human condition. The journal is intended to provide a forum for reporting the best and most rigorous from all disciplines ranging from and to and ... Introduction to the epilepsy syndrome papers We defined an epilepsy syndrome as "a characteristic cluster of clinical and EEG features, often supported by specific etiological findings (structural, genetic, metabolic, immune, and infectious).". The diagnosis of a syndrome in an individual with epilepsy frequently carries prognostic and treatment implications. State of the Art and Challenges in Epilepsy—A Narrative Review Epilepsy is a common condition worldwide, with approximately 50 million people suffering from it. A single seizure does not mean epilepsy; almost 10% of the population can have a seizure during their lifetime. In particular, there are many other central nervous system disorders other than epilepsy in which seizures occur, either transiently or as a comorbid condition. The impact of seizures ... Introduction to the epilepsy syndrome papers 6 Isabelle Rapin Division of Child Neurology, Saul R. Korey Department of Neurology, and Departments of Neuroscience and Pediatrics, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA. PMID: 35503711. DOI: 10.1111/epi.17262. No abstract available. (PDF) Epilepsy: pathophysiology, clinical manifestations and treatment Abstract. Epilepsy is a global health problem affecting approximately 50 million people worldwide. It is one of the most common chronic neurological diseases in the world and has serious physical ... Epilepsy research in 2022: clinical advances In 2022, epilepsy research has made advances across a range of clinically important areas, from self-management, genetics, imaging, and surgical planning to understanding febrile seizures and coma-related periodic patterns. Most notably, in May 2022, the World Health Assembly adopted the Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders, which aims to address gaps ... (PDF) Introduction to Epilepsy and Related Brain Disorders Introduction to Epilepsy and Related Brain Disorders. ... Current research converges on the notion that seizures erupt when two fundamental . ... Gloor's 1968 paper on corticoreticular epilepsy ... Landscape of epilepsy research: Analysis and future trajectory The descriptive study provides a geographical representation of publications related to epilepsy, covering the period from 2015 to 2023. Fig. 3 illustrates the distribution of published papers across different years, highlighting a notable increase in the number of publications expected between 2018 and 2023. Over the past five years, there has been a significant surge in epilepsy research ... PDF Introduction to the epilepsy syndrome papers This series of ILAE position papers represents the work of the Nosology and Definitions Task Force, established by the ILAE in 2017 to provide definitions of epilepsy syndromes. We defined an epilepsy syndrome as "a char-acteristic cluster of clinical and EEG features, often sup-ported by specific etiological findings (structural, genetic ... Epileptic Seizures Detection Using Deep Learning Techniques: A Review Introduction. Epilepsy is a noncommunicable disease and one of the most common neurological disorders of humans, ... substantial research has been done to detect epilepsy using DL models such as convolutional neural networks (CNNs), ... In this paper, a comprehensive review of works done in the field of epileptic seizure detection using various ... Journal of Epilepsy Research For assistance with manuscript submission, please contact: [email protected]. Free archive: Anyone may access any past or current articles without logging in. Editorial Office KCC Parktown 101-308, Mallijae-ro 185, Jung-Gu, Seoul, Korea TEL : +82 ... (PDF) Recent advances in epilepsy This paper reviews advances in epilepsy in recent years with an emphasis on therapeutics and underlying mechanisms, including status epilepticus, drug and surgical treatments. Lessons from rarer ... The inside experience of epilepsy: An essay about the ... Abstract. This essay addresses three aspects of the inside experience of epilepsy, i) the high semiological significance of subjective seizure symptoms, ii) the therapeutic consequences, both positive and negative, of subjective seizure experiences, and iii) the importance of recognizing the patient as the 'inside expert' of epilepsy. Epilepsy Epilepsy is a neurological disorder that affects about 65 million people worldwide. Although antiepileptic drugs provide sufficient control of seizures in approximately 70% of patients with epilepsy, the remaining 30% are resistant to monotherapy. This means around 20 million people worldwide face significant adverse life-long consequences such as sudden unexpected death from epileptic ... A review of automatic detection of epilepsy based on EEG signals Therefore, it is particularly important to realize the automatic detection of epilepsy. This paper introduces, in detail, the overall framework of EEG-based automatic epilepsy identification and the typical methods involved in each step. ... The following is an introduction to the research progress of epilepsy signal classification technology ... Introduction The names given to series of these publications vary, but are often such generic terms as "technical reports," "working papers," "research memoranda," "internal notes," "occasional papers," "discussion papers" or "gray (or grey) literature." In the physical and natural sciences, "technical report" seems to be the preferred designation. (PDF) Epilepsy and its Management: A Review The objective of the review is to discuss history, epidemiology, etiology, pathophysiology, classification of epilepsy, symtomps, diagnosis, management of epilepsy and its future trends ... An Introduction to Epilepsy NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. Editors: Edward B Bromfield, MD, José E Cavazos, MD, PhD, and Joseph I Sirven, MD. West Hartford (CT): American Epilepsy Society; 2006. An Introduction to Epilepsy was developed by the Student & Resident Education Subcommittee of the American Epilepsy ... assignment essay homework paper phd report resume review speech thesis